Results 31 to 40 of about 413,699 (314)

Gene-Based Therapies for Neurodegenerative Diseases

, 2023
While infectious viruses have had devastating effects throughout history, recently developed virus-based biotechnologies have the potential to revolutionize treatment of genetic diseases.
Zeid|, de Arruda, Thais Costa Macedo, Le, Caitlin My Hanh, Becker, Claire, Shan, Varsha, Nakahara, Kate, Zeid, Dana   +6 more
core   +1 more source

Ubiquitin in Neurodegenerative Diseases

Brain Pathology, 1993
Immunochemical staining to detect ubiquitin has become an essential technique in evaluating neurodegenerative processes. Age related staining is seen in myelin, in nerve processes in lysosome‐related dense bodies, and in corpora amylacea. There is a constant association between filamentous inclusions and the presence of ubiquitin.
J, Lowe, R J, Mayer, M, Landon
openaire   +2 more sources

Integrating Mitochondrial Biology into Innovative Cell Therapies for Neurodegenerative Diseases. [PDF]

The role of mitochondria in neurodegenerative diseases is crucial, and recent developments have highlighted its significance in cell therapy. Mitochondrial dysfunction has been implicated in various neurodegenerative disorders, including Alzheimers ...
Giulivi, Cecilia, James M. Angelastro, Cecilia Giulivi, Angelastro, James, Ore, Adaleiz, Adaleiz Ore   +5 more
core   +1 more source

Improving 3D convolutional neural network comprehensibility via interactive visualization of relevance maps: evaluation in Alzheimer’s disease

Alzheimer’s Research & Therapy, 2021
Background Although convolutional neural networks (CNNs) achieve high diagnostic accuracy for detecting Alzheimer’s disease (AD) dementia based on magnetic resonance imaging (MRI) scans, they are not yet applied in clinical routine.
Martin Dyrba, Moritz Hanzig, Slawek Altenstein, Sebastian Bader, Tommaso Ballarini, Frederic Brosseron, Katharina Buerger, Daniel Cantré, Peter Dechent, Laura Dobisch, Emrah Düzel, Michael Ewers, Klaus Fliessbach, Wenzel Glanz, John-Dylan Haynes, Michael T. Heneka, Daniel Janowitz, Deniz B. Keles, Ingo Kilimann, Christoph Laske, Franziska Maier, Coraline D. Metzger, Matthias H. Munk, Robert Perneczky, Oliver Peters, Lukas Preis, Josef Priller, Boris Rauchmann, Nina Roy, Klaus Scheffler, Anja Schneider, Björn H. Schott, Annika Spottke, Eike J. Spruth, Marc-André Weber, Birgit Ertl-Wagner, Michael Wagner, Jens Wiltfang, Frank Jessen, Stefan J. Teipel, for the ADNI, AIBL, DELCODE study groups   +40 more
doaj   +1 more source

Neurodegenerative Diseases [PDF]

, 2021
Neurodegenerative diseases represent a very large group of heterogeneous disorders affecting specific subtypes of neurons in the brain. This book contributes insight both to the awareness of the brain and its neurodegenerative states.

core   +2 more sources

FRET-based Tau seeding assay does not represent prion-like templated assembly of Tau filaments

Molecular Neurodegeneration, 2020
Tau aggregation into amyloid fibers based on the cross-beta structure is a hallmark of several Tauopathies, including Alzheimer Disease (AD). Trans-cellular propagation of Tau with pathological conformation has been suggested as a key disease mechanism ...
Senthilvelrajan Kaniyappan, Katharina Tepper, Jacek Biernat, Ram Reddy Chandupatla, Sabrina Hübschmann, Stephan Irsen, Sandra Bicher, Christoph Klatt, Eva-Maria Mandelkow, Eckhard Mandelkow   +9 more
doaj   +1 more source

Pathology of Neurodegenerative Diseases [PDF]

Cold Spring Harbor Perspectives in Biology, 2017
Neurodegenerative disorders are characterized by progressive loss of selectively vulnerable populations of neurons, which contrasts with select static neuronal loss because of metabolic or toxic disorders. Neurodegenerative diseases can be classified according to primary clinical features (e.g., dementia, parkinsonism, or motor neuron disease ...
Dugger, Brittany N, Dickson, Dennis W
openaire   +4 more sources

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Anti-aggregant tau mutant promotes neurogenesis

Molecular Neurodegeneration, 2017
Background The microtubule-associated protein Tau plays a role in neurodegeneration as well as neurogenesis. Previous work has shown that the expression of the pro-aggregant mutant Tau repeat domain causes strong aggregation and pronounced neuronal loss ...
Maria Joseph, Marta Anglada-Huguet, Katharina Paesler, Eckhard Mandelkow, Eva-Maria Mandelkow   +4 more
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source