Results 31 to 40 of about 2,554,961 (312)

The cytoskeleton in neurodegenerative diseases [PDF]

The Journal of Pathology, 2004
AbstractAbundant abnormal aggregates of cytoskeletal proteins are neuropathological signatures of many neurodegenerative diseases that are broadly classified by filamentous aggregates of neuronal intermediate filament (IF) proteins, or by inclusions containing the microtubule‐associated protein (MAP) tau.
Nigel J, Cairns, Virginia M-Y, Lee, John Q, Trojanowski   +2 more
openaire   +2 more sources

Process evaluation of the context, reach and recruitment of participants and delivery of dementia-specific case conferences (WELCOME-IdA) in nursing homes (FallDem): a mixed-methods study

Trials, 2019
Background A system of dementia-specific case conferences (WELCOME-IdA) was evaluated using a stepped-wedge design in six nursing homes (NHs) to enable nursing staff to analyse properly the behavioural and psychological symptoms (BPSD) of residents with ...
Daniela Holle, Rene Müller-Widmer, Sven Reuther, Ute Rosier-Segschneider, Rabea Graf, Martina Roes, Margareta Halek   +6 more
doaj   +1 more source

Neurodegenerative Diseases and Autophagy [PDF]

, 2018
Most neurodegenerative diseases are characterized by the accumulation of aggregated proteins within neurons. These aggregate-prone proteins cause toxicity, a phenomenon that is further exacerbated when there is defective protein clearance.
Pavel M., Andrea Caricasole, Licitra F., Vicinanza M., Füllgrabe J., Stephen P. Andrews, Caricasole A., Renna M., Lopez A., de Jager, Skidmore J., David C. Rubinsztein, Mariella Vicinanza, Claudia Puri, Jens Füllgrabe, Mariana Pavel, Puri C., Avraham Ashkenazi, S. M., Ashkenazi A., Maurizio Renna, Ana Lopez, FLEMING, ANGELEEN LOUISE, Angeleen Fleming, John Skidmore, Andrews S. P., Thomas Ricketts, Ricketts T., Floriana Licitra, Rubinsztein D. C., Sarah M. de Jager   +30 more
core   +1 more source

Inhibition of Stat3‐mediated astrogliosis ameliorates pathology in an Alzheimer's disease model

EMBO Molecular Medicine, 2019
Reactive astrogliosis is a hallmark of Alzheimer's disease (AD), but its role for disease initiation and progression has remained incompletely understood.
Nicole Reichenbach, Andrea Delekate, Monika Plescher, Franziska Schmitt, Sybille Krauss, Nelli Blank, Annett Halle, Gabor C Petzold   +7 more
doaj   +1 more source

Bayesian modeling of item heterogeneity in dichotomous recognition memory data and prospects for computerized adaptive testing

Scientific Reports, 2022
Most current models of recognition memory fail to separately model item and person heterogeneity which makes it difficult to assess ability at the latent construct level and prevents the administration of adaptive tests.
Jeremie Güsten, David Berron, Emrah Düzel, Gabriel Ziegler   +3 more
doaj   +1 more source

Caudo‐rostral brain spreading of α‐synuclein through vagal connections

EMBO Molecular Medicine, 2013
α‐Synuclein accumulation and pathology in Parkinson's disease typically display a caudo‐rostral pattern of progression, involving neuronal nuclei in the medulla oblongata at the earliest stages.
Ayse Ulusoy, Raffaella Rusconi, Blanca I. Pérez‐Revuelta, Ruth E. Musgrove, Michael Helwig, Bettina Winzen‐Reichert, Donato A. Di Monte   +6 more
doaj   +1 more source

Brainstem : neglected locus in neurodegenerative diseases [PDF]

, 2011
The most frequent neurodegenerative diseases (NDs) are Alzheimer’s disease (AD), Parkinson’s disease (PD), and frontotemporal lobar degeneration associated with protein TDP-43 (FTLD–TDP).
Lea Tenenholz Grinberg, Lea T Grinberg, Helmut Heinsen, Udo eRueb, Udo Rueb, Tenenholz Grinberg, Lea, Heinsen, Helmut, Rüb, Udo, Helmut eHeinsen   +8 more
core   +1 more source

TALKING TIME: A pilot randomized controlled trial investigating social support for informal caregivers via the telephone

BMC Health Services Research, 2020
Background Caring for people with dementia at home requires considerable time, organization and commitment. Therefore, informal caregivers of people with dementia are often overburdened. This study examined the effects of the telephone-based Talking Time
Martin Nikolaus Dichter, Bernd Albers, Diana Trutschel, Armin Michael Ströbel, Swantje Seismann-Petersen, Katharina Wermke, Margareta Halek, Martin Berwig   +7 more
doaj   +1 more source

In Search of a Function for the N6-Methyladenosine in Epitranscriptome, Autophagy and Neurodegenerative Diseases

, 2023
Changes in epitranscriptome with N6-methyladenine (m6A) modification could be involved in the development of multiple diseases, which might be a prevalent modification of messenger RNAs (mRNAs) in eukaryotes.
Haruka Sawamura, Yuka Ikeda, Sayuri Yoshikawa, Naoko Suga, Kurumi Taniguchi, Satoru Matsuda   +5 more
core   +1 more source

Neurodegenerative diseases: challenges [PDF]

Drug Delivery and Translational Research, 2011
Diseases of the aging brain—including Alzheimer’s, Parkinson’s, and Huntington’s—affect the lives of millions and pose a growing threat to public health. These diseases occur as a result of neurodegenerative processes involving the progressive loss of structure or function of neurons, including death of neurons.
openaire   +2 more sources