Results 11 to 20 of about 2,554,961 (312)
A multi-omics dataset for the analysis of frontotemporal dementia genetic subtypes
Scientific Data, 2023 Understanding the molecular mechanisms underlying frontotemporal dementia (FTD) is essential for the development of successful therapies. Systematic studies on human post-mortem brain tissue of patients with genetic subtypes of FTD are currently lacking.
Kevin Menden +19 more
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Proteotoxicity and Neurodegenerative Diseases [PDF]
International Journal of Molecular Sciences, 2020 Neurodegenerative diseases are a major burden for our society, affecting millions of people worldwide. A main goal of past and current research is to enhance our understanding of the mechanisms underlying proteotoxicity, a common theme among these incurable and debilitating conditions.
Ruz, Clara +4 more
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Aquaporins and Neurodegenerative Diseases [PDF]
Current Neuropharmacology, 2010 Aquaporins (AQPs) are a family of widely distributed membrane-inserted water channel proteins providing a pathway for osmotically-driven water, glycerol, urea or ions transport through cell membranes and mechanisms to control particular aspects of homeostasis.
Foglio E, RODELLA, Luigi Fabrizio
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Mitoepigenetics and Neurodegenerative Diseases [PDF]
Frontiers in Endocrinology, 2019 Mitochondrial impairment and increased oxidative stress are common features in neurodegenerative disorders, leading researchers to speculate that epigenetic changes in the mitochondrial DNA (mitoepigenetics) could contribute to neurodegeneration.
Coppede F., Stoccoro A.
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Neuregulins in Neurodegenerative Diseases [PDF]
Frontiers in Aging Neuroscience, 2021 Neurodegenerative diseases, including Alzheimer’s disease (AD), Parkinson’s disease (PD) and amyotrophic lateral sclerosis (ALS), are typically characterized by progressive neuronal loss and neurological dysfunctions in the nervous system, affecting both memory and motor functions.
Guan-yong Ou +3 more
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Caregiver Burden in Movement Disorders and Neurodegenerative Diseases: Editorial
, 2022 Caregiver burden is still an unmet need in the treatment of many neurodegenerative diseases [...
Martin Klietz, Klietz, Martin
core +1 more source
npj Parkinson's Disease, 2023 Individuals with Parkinson’s disease (PD) typically receive a diagnosis once they have developed motor symptoms, at which point there is already significant loss of substantia nigra dopamine neurons, α-synuclein accumulation in surviving neurons, and ...
Amber D. Van Laar +10 more
doaj +1 more source
Alzheimer’s Research & Therapy, 2023 Background Neuroinflammation constitutes a pathological hallmark of Alzheimer’s disease (AD). Still, it remains unresolved if peripheral inflammatory markers can be utilized for research purposes similar to blood-based beta-amyloid and neurodegeneration ...
Frederic Brosseron +52 more
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Molecular Mechanisms of Neurodegenerative Diseases: Emerging Biomarkers and Therapeutic Targets. [PDF]
Brain SciNeurodegenerative diseases (NDs), such as Alzheimer’s disease (AD), Parkinson’s disease (PD), Amyotrophic lateral sclerosis (ALS), and Huntington’s disease (HD), involve the gradual loss of structure or function of neurons in the ...
Yogi S, Singh A.
europepmc +2 more sources
Reelin Signaling in Neurodevelopmental Disorders and Neurodegenerative Diseases
, 2023 Reelin is an extracellular matrix glycoprotein involved in neuronal migration during embryonic brain development and synaptic plasticity in the adult brain.
Aurelie Joly-Amado +2 more
core +1 more source