Results 21 to 30 of about 413,699 (314)

Neurodegenerative Diseases and Autophagy [PDF]

, 2018
Most neurodegenerative diseases are characterized by the accumulation of aggregated proteins within neurons. These aggregate-prone proteins cause toxicity, a phenomenon that is further exacerbated when there is defective protein clearance.
Pavel M., Andrea Caricasole, Licitra F., Vicinanza M., Füllgrabe J., Stephen P. Andrews, Caricasole A., Renna M., Lopez A., de Jager, Skidmore J., David C. Rubinsztein, Mariella Vicinanza, Claudia Puri, Jens Füllgrabe, Mariana Pavel, Puri C., Avraham Ashkenazi, S. M., Ashkenazi A., Maurizio Renna, Ana Lopez, FLEMING, ANGELEEN LOUISE, Angeleen Fleming, John Skidmore, Andrews S. P., Thomas Ricketts, Ricketts T., Floriana Licitra, Rubinsztein D. C., Sarah M. de Jager   +30 more
core   +1 more source

Caudo‐rostral brain spreading of α‐synuclein through vagal connections

EMBO Molecular Medicine, 2013
α‐Synuclein accumulation and pathology in Parkinson's disease typically display a caudo‐rostral pattern of progression, involving neuronal nuclei in the medulla oblongata at the earliest stages.
Ayse Ulusoy, Raffaella Rusconi, Blanca I. Pérez‐Revuelta, Ruth E. Musgrove, Michael Helwig, Bettina Winzen‐Reichert, Donato A. Di Monte   +6 more
doaj   +1 more source

Immunotherapies for Neurodegenerative Diseases [PDF]

Frontiers in Neurology, 2021
The current treatments for neurodegenerative diseases are mostly symptomatic without affecting the underlying cause of disease. Emerging evidence supports a potential role for immunotherapy in the management of disease progression. Numerous reports raise the exciting prospect that either the immune system or its derivative components could be harnessed
Ibrahim Mortada, Raymond Farah, Sanaa Nabha, David M. Ojcius, Youssef Fares, Wassim Y. Almawi, Najwane Said Sadier, Najwane Said Sadier   +7 more
openaire   +5 more sources

TALKING TIME: A pilot randomized controlled trial investigating social support for informal caregivers via the telephone

BMC Health Services Research, 2020
Background Caring for people with dementia at home requires considerable time, organization and commitment. Therefore, informal caregivers of people with dementia are often overburdened. This study examined the effects of the telephone-based Talking Time
Martin Nikolaus Dichter, Bernd Albers, Diana Trutschel, Armin Michael Ströbel, Swantje Seismann-Petersen, Katharina Wermke, Margareta Halek, Martin Berwig   +7 more
doaj   +1 more source

Bayesian modeling of item heterogeneity in dichotomous recognition memory data and prospects for computerized adaptive testing

Scientific Reports, 2022
Most current models of recognition memory fail to separately model item and person heterogeneity which makes it difficult to assess ability at the latent construct level and prevents the administration of adaptive tests.
Jeremie Güsten, David Berron, Emrah Düzel, Gabriel Ziegler   +3 more
doaj   +1 more source

In Search of a Function for the N6-Methyladenosine in Epitranscriptome, Autophagy and Neurodegenerative Diseases

, 2023
Changes in epitranscriptome with N6-methyladenine (m6A) modification could be involved in the development of multiple diseases, which might be a prevalent modification of messenger RNAs (mRNAs) in eukaryotes.
Haruka Sawamura, Yuka Ikeda, Sayuri Yoshikawa, Naoko Suga, Kurumi Taniguchi, Satoru Matsuda   +5 more
core   +1 more source

Glucocerebrosidase is imported into mitochondria and preserves complex I integrity and energy metabolism

Nature Communications, 2023
GBA1 mutations cause Gaucher’s disease and are the strongest risk factor for Parkinson’s disease. Using stable cell lines and patient iPSCs, the authors show mitochondrial localization of GBA1, which may affect neurodegenerative disease risk.
Pascale Baden, Maria Jose Perez, Hariam Raji, Federico Bertoli, Stefanie Kalb, María Illescas, Fokion Spanos, Claudio Giuliano, Alessandra Maria Calogero, Marvin Oldrati, Hannah Hebestreit, Graziella Cappelletti, Kathrin Brockmann, Thomas Gasser, Anthony H. V. Schapira, Cristina Ugalde, Michela Deleidi   +16 more
doaj   +1 more source

Role of medicinal plants in neurodegenerative diseases [PDF]

, 2017
Neurodegenerative diseases, such as Alzheimer’s disease (AD) and Parkinson’s disease (PD), are characterized by progressive loss (and even death) of structure and function of neurons, and have created great burden to the individual and the society.
Ratheesh, Greeshma, Tian, Lingling, Tai-Ping Fan, Greeshma Ratheesh, Sadiq, Asif, Fan, Tai-Ping, Ezhilarasu, Hariharan, Jayarama Reddy Venugopal, Seeram Ramakrishna, Asif Sadiq, Venugopal, Jayarama Reddy, Ramakrishna, Seeram, Hariharan Ezhilarasu, Lingling Tian   +13 more
core   +1 more source

Inflammation in neurodegenerative diseases [PDF]

Immunology, 2010
Summary Neurodegeneration, the slow and progressive dysfunction and loss of neurons and axons in the central nervous system, is the primary pathological feature of acute and chronic neurodegenerative conditions such as Alzheimer’s disease and Parkinson’s disease, neurotropic viral infections, stroke, paraneoplastic disorders, traumatic brain injury and
Amor, S., Puentes, F., Baker, D., van der Valk, P.   +3 more
openaire   +2 more sources

Exploring the ATN classification system using brain morphology

Alzheimer’s Research & Therapy, 2023
Background The NIA-AA proposed amyloid-tau-neurodegeneration (ATN) as a classification system for AD biomarkers. The amyloid cascade hypothesis (ACH) implies a sequence across ATN groups that patients might undergo during transition from healthy towards ...
Nils Heinzinger, Anne Maass, David Berron, Renat Yakupov, Oliver Peters, Jochen Fiebach, Kersten Villringer, Lukas Preis, Josef Priller, Eike Jacob Spruth, Slawek Altenstein, Anja Schneider, Klaus Fliessbach, Jens Wiltfang, Claudia Bartels, Frank Jessen, Franziska Maier, Wenzel Glanz, Katharina Buerger, Daniel Janowitz, Robert Perneczky, Boris-Stephan Rauchmann, Stefan Teipel, Ingo Killimann, Doreen Göerß, Christoph Laske, Matthias H. Munk, Annika Spottke, Nina Roy, Michael T. Heneka, Frederic Brosseron, Laura Dobisch, Michael Ewers, Peter Dechent, John Dylan Haynes, Klaus Scheffler, Steffen Wolfsgruber, Luca Kleineidam, Matthias Schmid, Moritz Berger, Emrah Düzel, Gabriel Ziegler, for the Alzheimer’s Disease Neuroimaging Initiative   +42 more
doaj   +1 more source