Results 21 to 30 of about 2,554,961 (312)

Microglia in neurodegenerative diseases

Neural Regeneration Research, 2020
A major feature of neurodegeneration is disruption of central nervous system homeostasis, during which microglia play diverse roles. In the central nervous system, microglia serve as the first line of immune defense and function in synapse pruning, injury repair, homeostasis maintenance, and regulation of brain development through scavenging and ...
Yu Xu, Ming-Zhu Jin, Ze-Yong Yang, Wei-Lin Jin   +3 more
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Reactivated endogenous retroviruses promote protein aggregate spreading

Nature Communications, 2023
Prion-like spreading of protein misfolding is a characteristic of neurodegenerative diseases, but the exact mechanisms of intercellular protein aggregate dissemination remain unresolved.
Shu Liu, Stefanie-Elisabeth Heumüller, André Hossinger, Stephan A. Müller, Oleksandra Buravlova, Stefan F. Lichtenthaler, Philip Denner, Ina M. Vorberg   +7 more
doaj   +1 more source

Safety and efficacy of human embryonic stem cell-derived astrocytes following intrathecal transplantation in SOD1G93A and NSG animal models

Stem Cell Research & Therapy, 2018
Background Amyotrophic lateral sclerosis (ALS) is a motor neuron (MN) disease characterized by the loss of MNs in the central nervous system. As MNs die, patients progressively lose their ability to control voluntary movements, become paralyzed and ...
Michal Izrael, Shalom Guy Slutsky, Tamar Admoni, Louisa Cohen, Avital Granit, Arik Hasson, Joseph Itskovitz-Eldor, Lena Krush Paker, Graciela Kuperstein, Neta Lavon, Shiran Yehezkel Ionescu, Leonardo Javier Solmesky, Rachel Zaguri, Alina Zhuravlev, Ella Volman, Judith Chebath, Michel Revel   +16 more
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Prominent microglial inclusions in transgenic mouse models of α-synucleinopathy that are distinct from neuronal lesions

Acta Neuropathologica Communications, 2020
Alpha-synucleinopathies are a group of progressive neurodegenerative disorders, characterized by intracellular deposits of aggregated α-synuclein (αS). The clinical heterogeneity of these diseases is thought to be attributed to conformers (or strains) of
Gaye Tanriöver, Mehtap Bacioglu, Manuel Schweighauser, Jasmin Mahler, Bettina M. Wegenast-Braun, Angelos Skodras, Ulrike Obermüller, Melanie Barth, Deborah Kronenberg-Versteeg, K. Peter R. Nilsson, Derya R. Shimshek, Philipp J. Kahle, Yvonne S. Eisele, Mathias Jucker   +13 more
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Advances in Neurodegenerative Diseases

, 2022
A multitude of diseases presenting a wide variety of phenotypic appearances are included in neurodegenerative disorders [...
Efthimios Dardiotis, Vasileios Siokas
core   +1 more source

Systemic gene delivery to the central nervous system using Adeno-associated virus

Frontiers in Molecular Neuroscience, 2014
Adeno-associated virus (AAV)-mediated gene delivery has emerged as an effective and safe tool for both preclinical and clinical studies of neurological disorders.
Mathieu eBOURDENX, Mathieu eBOURDENX, Nathalie eDUTHEIL, Nathalie eDUTHEIL, Erwan eBEZARD, Erwan eBEZARD, Benjamin eDEHAY, Benjamin eDEHAY   +7 more
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Structural MRI of the basal forebrain as predictor of cognitive response to galantamine in healthy older adults—A randomized controlled double‐blinded crossover study

Alzheimer’s & Dementia: Translational Research & Clinical Interventions, 2021
Introduction Cholinesterase inhibitors can enhance cognitive functions in healthy elderly and delay cognitive decline in patients with Alzheimer`s disease (AD). However, not everyone benefits from this treatment (non‐responders).
Patrick Müller, Anne‐Katrin Vellage, Marlen Schmicker, Inga Menze, Michel J. Grothe, Stefan J. Teipel, Notger G. Müller   +6 more
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Synapses in neurodegenerative diseases [PDF]

BMB Reports, 2017
Synapse is the basic structural and functional component for neural communication in the brain. The presynaptic terminal is the structural and functionally essential area that initiates communication and maintains the continuous functional neural information flow.
Bae, Jae Ryul, Kim, Sung Hyun
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Hallucinations in Neurodegenerative Diseases [PDF]

CNS Neuroscience & Therapeutics, 2011
SUMMARYPatients with neurodegenerative disease frequently experience hallucinations and illusionary perceptions. As early symptoms, hallucinations may even have diagnostic relevance (i.e., for the diagnosis of Lewy Body Dementia). In the later course of the disease, hallucinations may appear as characteristic symptoms and often constitute a particular ...
Lothar, Burghaus, Carsten, Eggers, Lars, Timmermann, Gereon R, Fink, Nico J, Diederich   +4 more
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Hallmarks of neurodegenerative diseases

Cell, 2023
Decades of research have identified genetic factors and biochemical pathways involved in neurodegenerative diseases (NDDs). We present evidence for the following eight hallmarks of NDD: pathological protein aggregation, synaptic and neuronal network dysfunction, aberrant proteostasis, cytoskeletal abnormalities, altered energy homeostasis, DNA and RNA ...
Wilson III, David M., Cookson, Mark R., Van Den Bosch, Ludo, Zetterberg, Henrik, Holtzman, David M., Dewachter, Ilse   +5 more
openaire   +5 more sources