Results 41 to 50 of about 413,699 (314)

Wolfberry polysaccharide protects primary cortical neurons from homocysteine-induced neurotoxicity [PDF]

, 2009
The 9th International Conference of the Alzheimer's and Parkinson's Diseases: Advances, concepts and new Challenges, Prague, Czech Republic, 11-15 March 2009. In Neurodegenerative Diseases, 2009, v. 6 suppl.
Yu, MS, Yuen, WH, Ho, YS, So, KF, Yang, X, Chang, RCC   +5 more
core   +2 more sources

The economic burden of subjective cognitive decline, mild cognitive impairment and Alzheimer's dementia: excess costs and associated clinical and risk factors

Alzheimer’s Research & Therapy
Background With the availability of first disease-modifying treatments, evidence on costs across the entire Alzheimer's Continuum, especially for early disease stages, becomes increasingly important to inform healthcare planning, resource allocation, and
Eva Gläser, Ingo Kilimann, Moritz Platen, Wolfgang Hoffmann, Frederic Brosseron, Katharina Buerger, Marie Coenjaerts, Emrah Düzel, Michael Ewers, Klaus Fliessbach, Ingo Frommann, Maria Gemenetzi, Wenzel Glanz, Julian Hellmann-Regen, Enise I. Incesoy, Daniel Janowitz, Frank Jessen, Oliver Peters, Josef Priller, Alfredo Ramirez, Anja Schneider, Annika Spottke, Eike Jakob Spruth, Stefan Teipel, Michael Wagner, Bernhard Michalowsky   +25 more
doaj   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

Pharmacotherapy of Neurodegenerative Diseases

, 2022
Amyotrophic Lateral Sclerosis (ALS) is a fatal idiopathic neurodegenerative disease that is characterized by degeneration of both upper and lower motor neurons. ALS currently only has 2 drugs approved as disease modyfying, whereas the rest of the therapy
Adem, Muna Abdu
core  

Peroxiredoxins in Neurodegenerative Diseases [PDF]

Antioxidants, 2020
Substantial evidence indicates that oxidative/nitrosative stress contributes to the neurodegenerative diseases. Peroxiredoxins (PRDXs) are one of the enzymatic antioxidant mechanisms neutralizing reactive oxygen/nitrogen species. Since mammalian PRDXs were identified 30 years ago, their significance was long overshadowed by the other well-studied ROS ...
openaire   +3 more sources

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

Dysfunction of the episodic memory network in the Alzheimer’s disease cascade

Nature Communications
Alzheimer’s disease (AD) is a major cause of dementia and cognitive decline. Here, we assessed how episodic memory (EM) network dysfunction, a hallmark of AD, is related to the longitudinal progression of AD biomarkers, neurodegeneration and cognition ...
René Lattmann, Niklas Vockert, Jose Bernal, Judith Wesenberg, Yanin Suksangkharn, Renat Yakupov, Hartmut Schütze, Wenzel Glanz, Enise Incesoy, Michaela Butryn, Falk Lüsebrink, Matthias Schmid, Melina Stark, Luca Kleineidam, Annika Spottke, Marie Coenjaerts, Frederic Brosseron, Klaus Fliessbach, Anja Schneider, Peter Dechent, Klaus Scheffler, Stefan Hetzer, Alfredo Ramirez, Christoph Laske, Sebastian Sodenkamp, Slawek Altenstein, Luisa-Sophie Schneider, Daria Gref, Eike Jakob Spruth, Andrea Lohse, Björn H. Schott, Jens Wiltfang, Ingo Kilimann, Doreen Goerss, Ayda Rostamzadeh, Josef Priller, Oliver Peters, Julian Hellmann-Regen, Stefan Teipel, Michael Wagner, Frank Jessen, Anne Maass, Gabriel Ziegler, Emrah Düzel   +43 more
doaj   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Memory in Neurodegenerative Disease [PDF]

Journal of Neurology, Neurosurgery & Psychiatry, 1999
Memory in Neurodegenerative Disease . Edited by alexander i troster. (Pp 413, £60.00 (US $95.00). Published by Cambridge University Press, Cambridge 1998. ISBN 0-521-57192-8. No one can doubt the increasing importance, to affected families and the healthcare system, of Alzheimer’s disease, Parkinson’s disease, and the other degenerative conditions of ...
openaire   +2 more sources

Study on Genotypes and Phenotypes of Neurodegenerative Diseases

Neurodegenerative diseases are a heterogeneous group of age-related disorders characterised by the progressive degeneration or death of neurons in the central or peripheral nervous system. The prevalence of these diseases is increasing, in part due to an
Claudia Ricci
core   +2 more sources