Results 1 to 10 of about 167,403 (289)

Amyotrophic lateral sclerosis [PDF]

Nature Reviews Disease Primers, 2017
Amyotrophic lateral sclerosis (ALS), also known as motor neuron disease, is characterized by the degeneration of both upper and lower motor neurons, which leads to muscle weakness and eventual paralysis. Until recently, ALS was classified primarily within the neuromuscular domain, although new imaging and neuropathological data have indicated the ...
Hardiman, Orla, Al-Chalabi, Ammar, Chio, Adriano, Corr, Emma M., Logroscino, Giancarlo, Robberecht, Wim, Shaw, Pamela J., Simmons, Zachary, Van Den Berg, Leonard H.   +8 more
exaly   +23 more sources

Amyotrophic lateral sclerosis [PDF]

The Lancet, 2011
Amyotrophic lateral sclerosis (ALS) is an idiopathic, fatal neurodegenerative disease of the human motor system. In this Seminar, we summarise current concepts about the origin of the disease, what predisposes patients to develop the disorder, and discuss why all cases of ALS are not the same.
Kiernan, M, Vucic, S, Cheah, B, Turner, M, Eisen, A, Hardiman, O, Burrell, JR, Zoing, M   +7 more
exaly   +9 more sources

Amyotrophic Lateral Sclerosis [PDF]

, 2019
The word amyotrophic is derived from Greek, and means “without nourishment to muscles”, lateral means to the sides and sclerosis means hardened (“What is ALS?,” n.d.).
Georgetson, Anastasia M.
core   +4 more sources

RNAseq Analyses Identify Tumor Necrosis Factor-Mediated Inflammation as a Major Abnormality in ALS Spinal Cord [PDF]

, 2016
ALS is a rapidly progressive, devastating neurodegenerative illness of adults that produces disabling weakness and spasticity arising from death of lower and upper motor neurons.
A Al-Chalabi, A Chesi, A Dobin, A Hirano, A Kratz, A McKenna, A Saito, A Zhou, AB van Spriel, AE Renton, AM Bolger, AT Kwon, B Hoesel, B Ikiz, B Tian, B Zhang, C Cereda, C Figueroa-Romero, C Trapnell, Cedric Raoul, CG Saris, CM Higgins, CY Jin, D Brustolim, D Kim, D Kim, D Liu, D Nagy, D Schiffer, David G. Brohawn, DJ Park, ED Hall, EW Stommel, GA Van der Auwera, GN Babu, H Jeong, H Li, H Tanaka, IM Chiu, IR Holtman, J Ganesalingam, J Kong, J Satoh, James P. Bennett, JL Elliott, JS Henkel, JS Henkel, K Hattermann, K Hensley, KE Lewis, KM Mohler, L Probert, Laura C. O’Brien, LB Fanning, LC O'Brien, LJ Kogelman, M Damiano, M Hausmann, M Maschietto, M Mattiazzi, M Poloni, M Prudencio, MA DePristo, MD Robinson, ME Alexianu, ME Rusiniak, MG Hinds, MI Love, MJ Landrum, MR Turner, MW Amoroso, O Abel, O Hardiman, O Micheau, P Corcia, P Langfelder, PB Verghese, PD Stenson, PG Engstrom, PK Andrus, PR Heath, RJ Ferrante, S Abel, S Anders, S Byrne, S Hagl, S Horvath, S Khan, S Sasaki, S Sasaki, SL Carter, SN Dowey, SS Han, T Yoshihara, W Zhao, Y Chang, Y Ma, YJ Surh, Z Wang, ZH Zhang   +99 more
core   +21 more sources

Limits of and Alternatives to Conventional Medicine in the Context of Terminal Illness (e.g., Palliative Care)

Ethics in Progress, 2022
This paper aims at analysing the evolution of palliative care in the international context and their role in the path of care for the patient and the family.
Stefania Bastianello, Daniela Antonella Cattaneo   +1 more
doaj   +1 more source

The experience of children with a parent suffering from Amyotrophic Lateral Sclerosis during the COVID-19 pandemic

Scientific Reports, 2021
Children that have a parent with Amyotrophic Lateral Sclerosis (ALS) suffer from the progressive loss of their beloved ones. During the COVID-19 pandemic, the difficulties faced by these children have increased.
Ines Testoni, Lorenza Palazzo, Lucia Ronconi, Gabriella Rossi, Jenny Ferizoviku, Jose Ramon Pernia Morales   +5 more
doaj   +1 more source

The landscape of cognitive impairment in superoxide dismutase 1-amyotrophic lateral sclerosis

Neural Regeneration Research, 2023
Although mutations in the superoxide dismutase 1 gene account for only a minority of total amyotrophic lateral sclerosis cases, the discovery of this gene has been crucial for amyotrophic lateral sclerosis research. Since the identification of superoxide
Ilaria Martinelli, Elisabetta Zucchi, Cecilia Simonini, Giulia Gianferrari, Giovanna Zamboni, Marcello Pinti, Jessica Mandrioli   +6 more
doaj   +1 more source

Creatine kinase in the diagnosis and prognostic prediction of amyotrophic lateral sclerosis: a retrospective case-control study

Neural Regeneration Research, 2021
Creatine kinase is a muscle enzyme that has been reported at various levels in different studies involving patients with amyotrophic lateral sclerosis.
Xue-Ping Chen, Qian-Qian Wei, Ru-Wei Ou, Yan-Bing Hou, Ling-Yu Zhang, Xiao-Qin Yuan, Yun-Qian Yao, De-Sheng Jia, Qian Zhang, Wei-Xue Li, Hui-Fang Shang   +10 more
doaj   +1 more source

H63D CG genotype of HFE is associated with increased risk of sporadic amyotrophic lateral sclerosis in a single population [PDF]

Journal of Integrative Neuroscience, 2020
This paper describes the genetic etiology of sporadic amyotrophic lateral sclerosis in a single population. Polymerase chain reaction-restriction fragment length polymorphism and DNA sample sequencing of 3 common HFE gene variants (C282Y and H63D and ...
Qing-Qing Zhang, Hong Jiang, Chun-Yan Li, Ya-Ling Liu, Xin-Ying Tian
doaj   +1 more source

Botulinum toxin for the treatment of lower limb cramp pain in patients with Amyotrophic Lateral Sclerosis [PDF]

, 2020
Background: Muscle cramps and pain associated with them can be seen in patients with amyotrophic lateral sclerosis (ALS) and are known to reduce the quality of life. Pharmacological treatment may not benefit all patients in treating these cramps.
Govindarajan, Raghav, Mehta, Tejas, Sommers, Richard   +2 more
core   +2 more sources