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Amyotrophic lateral sclerosis [PDF]
Nature Reviews Disease Primers, 2017 Amyotrophic lateral sclerosis (ALS), also known as motor neuron disease, is characterized by the degeneration of both upper and lower motor neurons, which leads to muscle weakness and eventual paralysis. Until recently, ALS was classified primarily within the neuromuscular domain, although new imaging and neuropathological data have indicated the ...
Orla Hardiman +2 more
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Lancet, The, 2022 Amyotrophic lateral sclerosis is a fatal CNS neurodegenerative disease. Despite intensive research, current management of amyotrophic lateral sclerosis remains suboptimal from diagnosis to prognosis. Recognition of the phenotypic heterogeneity of amyotrophic lateral sclerosis, global CNS dysfunction, genetic architecture, and development of novel ...
Eva L Feldman +2 more
exaly +5 more sources
Ethics in Progress, 2022 This paper aims at analysing the evolution of palliative care in the international context and their role in the path of care for the patient and the family.
Stefania Bastianello +1 more
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Scientific Reports, 2021 Children that have a parent with Amyotrophic Lateral Sclerosis (ALS) suffer from the progressive loss of their beloved ones. During the COVID-19 pandemic, the difficulties faced by these children have increased.
Ines Testoni +5 more
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The landscape of cognitive impairment in superoxide dismutase 1-amyotrophic lateral sclerosis
Neural Regeneration Research, 2023 Although mutations in the superoxide dismutase 1 gene account for only a minority of total amyotrophic lateral sclerosis cases, the discovery of this gene has been crucial for amyotrophic lateral sclerosis research. Since the identification of superoxide
Ilaria Martinelli +6 more
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Neural Regeneration Research, 2021 Creatine kinase is a muscle enzyme that has been reported at various levels in different studies involving patients with amyotrophic lateral sclerosis.
Xue-Ping Chen +10 more
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H63D CG genotype of HFE is associated with increased risk of sporadic amyotrophic lateral sclerosis in a single population [PDF]
Journal of Integrative Neuroscience, 2020 This paper describes the genetic etiology of sporadic amyotrophic lateral sclerosis in a single population. Polymerase chain reaction-restriction fragment length polymorphism and DNA sample sequencing of 3 common HFE gene variants (C282Y and H63D and ...
Qing-Qing Zhang, Hong Jiang, Chun-Yan Li, Ya-Ling Liu, Xin-Ying Tian
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Frontiers in Neurology, 2020 Objective: To analyze those factors contributing to the diagnostic delay in ALS.Methods: Consecutive ALS patients were categorized as those studied in departmental hospitals and those studied in a referral ALS center.
Marina Martínez-Molina +16 more
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Neural Regeneration Research, 2022 Amyotrophic lateral sclerosis is a fatal neurodegenerative disease characterized by progressive muscle wasting, breathing and swallowing difficulties resulting in patient’s death in two to five years after disease onset. In amyotrophic lateral sclerosis,
Maria N Zakharova, Anna A Abramova
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Amyotrophic lateral sclerosis viewed from a patient’s perspective
Monaldi Archives for Chest Disease, 2016 -
M. Melazzini
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