Results 31 to 40 of about 1,041,663 (304)

Chromosome 9 ALS and FTD locus is probably derived from a single founder. [PDF]

, 2012
We and others have recently reported an association between amyotrophic lateral sclerosis (ALS) and single nucleotide polymorphisms on chromosome 9p21 in several populations.
Rollinson, PS, DeJesus-Hernandez, M, Pentti J. Tienari, Hardy, J, Morrison, Karen E., Aleksey Shatunov, John C. van Swieten, Rademakers, R, Restagno, Gabriella, Bryan J. Traynor, Rollinson, Pamela Sara, Karen E. Morrison, Ian R. Mackenzie, Morris, Huw Rees, Traynor, BJ, Mariely DeJesus-Hernandez, Morrison, KE, Pamela Sara Rollinson, Mackenzie, Ian R., Simón-Sánchez, J, Nalls, MA, van Swieten, J.C., Waite, Adrian, Javier Simón-Sánchez, Boeve, Bradley F., Morrison, Karen, Nalls, Michael A., Restagno, G, Myllykangas, L, Boxer, Adam L., Waite, Adrian James, Ammar Al-Chalabi, Waite, A, Mora, G, Heutink, P, Boeve, BF, Traynor, Bryan J., Adam L. Boxer, Shatunov, Aleksey, Rosa Rademakers, DeJesus-Hernandez, Mariely, Mackenzie, IR, Nigel Williams, Pickering-Brown, S, Hannu Laaksovirta, Chiò, A, Williams, N, Simón-Sánchez, Javier, Laaksovirta, Hannu, Mok, K, Laaksovirta, H, Adrian Waite, Shaw, Pamela J., Pickering-Brown, Stuart, Rademakers, Rosa, Heutink, Peter, van Swieten, JC, Tienari, PJ, Liisa Myllykangas, Peuralinna, T, Morris, HR, Hardy, John, Schymick, J, Shatunov, A, John Hardy, Huw R. Morris, Gabriele Mora, Peuralinna, Terhi, Chio', Adriano, Peter Heutink, Richard W. Orrell, Terhi Peuralinna, Morrison, Karen E.; id_orcid, Myllykangas, Liisa, Williams, Nigel, Bradley F. Boeve, Gabriella Restagno, Pamela J. Shaw, Orrell, RW, Shatunov, Aleksey; id_orcid, Kin Mok, Al-Chalabi, Ammar, Boxer, AL, Mok, Kin, Mora, Gabriele, Orrell, Richard W., Tienari, Pentti J., Adriano Chiò, Schymick, Jennifer, Morris, Huw R., Shaw, PJ, Williams, Nigel Melville, Al-Chalabi, A, Chiò, Adriano, van Swieten, John C., Michael A. Nalls, Stuart Pickering-Brown, Jennifer Schymick   +97 more
core   +1 more source

Amyotrophic lateral sclerosis

The Lancet, 2011
Amyotrophic lateral sclerosis (ALS) is an idiopathic, fatal neurodegenerative disease of the human motor system. In this Seminar, we summarise current concepts about the origin of the disease, what predisposes patients to develop the disorder, and discuss why all cases of ALS are not the same.
Kiernan, M, Vucic, S, Cheah, B, Turner, M, Eisen, A, Hardiman, O, Burrell, JR, Zoing, M   +7 more
openaire   +5 more sources

Control in the absence of choice: A qualitative study on decision-making about gastrostomy in people with amyotrophic lateral sclerosis, caregivers, and healthcare professionals.

PLoS ONE, 2023
BackgroundGastrostomy is recommended in amyotrophic lateral sclerosis for long-term nutritional support, however, people with amyotrophic lateral sclerosis and healthcare professionals perceive decision-making as complex.MethodTo explore their ...
Remko M van Eenennaam, Neele Rave, Willeke J Kruithof, Esther T Kruitwagen-van Reenen, Leonard H van den Berg, Johanna A Visser-Meily, Anita Beelen   +6 more
doaj   +1 more source

Microstructural Correlates of Emotional Attribution Impairment in Non-Demented Patients with Amyotrophic Lateral Sclerosis. [PDF]

PLoS ONE, 2016
Impairments in the ability to recognize and attribute emotional states to others have been described in amyotrophic lateral sclerosis patients and linked to the dysfunction of key nodes of the emotional empathy network. Microstructural correlates of such
Chiara Crespi, Chiara Cerami, Alessandra Dodich, Nicola Canessa, Sandro Iannaccone, Massimo Corbo, Christian Lunetta, Andrea Falini, Stefano F Cappa   +8 more
doaj   +1 more source

Amyotrophic Lateral Sclerosis: An Analysis of the Electromyographic Fatigue of the Masticatory Muscles

Prague Medical Report, 2022
Amyotrophic lateral sclerosis is a chronic degenerative disease that affects motor neurons, thereby promoting functional changes in the human body.
Ligia Maria Napolitano Gonçalves, Selma Siéssere, Flávia Argentato Cecilio, Jaime Eduardo Cecilio Hallak, Paulo Batista de Vasconcelos, Wilson Marques Júnior, Isabela Hallak Regalo, Marcelo Palinkas, Simone Cecilio Hallak Regalo   +8 more
doaj   +1 more source

Amyotrophic lateral sclerosis and cerebellum

Scientific Reports, 2022
AbstractAmyotrophic lateral sclerosis (ALS) is a devastating, heterogeneous neurodegenerative neuromuscular disease that leads to a fatal outcome within 2–5 years, and yet, a precise nature of the association between its major phenotypes and the cerebellar role in ALS pathology remains unknown.
Kabiljo, R, Iacoangeli, A, Al-Chalabi, A, Rosenzweig, I   +3 more
openaire   +4 more sources

CSF concentrations of cAMP and cGMP are lower in patients with Creutzfeldt-Jakob disease but not Parkinson's disease and amyotrophic lateral sclerosis. [PDF]

, 2012
The cyclic nucleotides cyclic adenosine-3',5'-monophosphate (cAMP) and cyclic guanosine-3',5'-monophosphate (cGMP) are important second messengers and are potential biomarkers for Parkinson's disease (PD), amyotrophic lateral sclerosis (ALS) and ...
Oeckl, Patrick, Albert C Ludolph, Hans A Kretzschmar, Ludolph, Albert C., Markus Otto, Kretzschmar, Hans A., Petra Steinacker, Stefan Lehnert, Ferger Boris, Patrick Oeckl, Otto, Markus, Ferger, Boris, Oeckl Patrick, Ludolph Albert C., Boris Ferger, Steinacker, Petra, Otto Markus, Lehnert Stefan, Steinacker Petra, Kretzschmar Hans A., Jesse, Sarah, Lehnert, Stefan, Sarah Jesse, Jesse Sarah   +23 more
core   +1 more source

Elevated Levels of Methylmalonate and Homocysteine in Parkinson's Disease, Progressive Supranuclear Palsy and Amyotrophic Lateral Sclerosis [PDF]

, 2010
Background/Aims: Increasing evidence suggests that elevated levels of homocysteine (Hcy) and methylmalonate (MMA) may be involved in the pathogenesis of neurodegenerative diseases. Methods: The urine levels of MMA and serum levels of Hcy as well as folic
Armin Giese, Michael Vogeser, Levin, Johannes, Bötzel, Kai, Kai Bötzel, Vogeser, Michael, Johannes Levin, Lorenzl, Stefan, Stefan Lorenzl, Giese, Armin   +9 more
core   +1 more source

Amyotrophic lateral sclerosis [PDF]

Orphanet Journal of Rare Diseases, 2009
Abstract Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterised by progressive muscular paralysis reflecting degeneration of motor neurones in the primary motor cortex, corticospinal tracts, brainstem and spinal cord.
Leigh P Nigel, Wijesekera Lokesh C
openaire   +3 more sources

Plasma Neurofilament Heavy Chain Levels Correlate to Markers of Late Stage Disease Progression and Treatment Response in SOD1(G93A) Mice that Model ALS [PDF]

, 2012
Background: Amyotrophic lateral sclerosis (ALS) is an incurable neurodegenerative disorder characterised by progressive degeneration of motor neurons leading to death, typically within 3–5 years of symptom onset. The diagnosis of ALS is largely reliant
Greensmith Linda, Dick, J, Petzold, A, Linda Greensmith, Malaspina Andrea, Petzold Axel, Greensmith, L, Kalmar Bernadett, Kalmar, B, Dick James, Lu Ching-Hua, Lu, CH, Bernadett Kalmar, James Dick, Ching-Hua Lu, Lu, C-H, Andrea Malaspina, Malaspina, A, Axel Petzold   +18 more
core   +2 more sources