Results 51 to 60 of about 995,258 (307)

Progressive brainstem pathology in motor neuron diseases: Imaging data from amyotrophic lateral sclerosis and primary lateral sclerosis

Data in Brief, 2020
A standardised, single-centre, longitudinal imaging protocol was used to evaluate longitudinal brainstem alterations in 100 patients with amyotrophic lateral sclerosis (ALS) with reference to 33 patients with primary lateral sclerosis (PLS), 30 patients ...
Peter Bede, Rangariroyashe H. Chipika, Eoin Finegan, Stacey Li Hi Shing, Kai Ming Chang, Mark A. Doherty, Jennifer C. Hengeveld, Alice Vajda, Siobhan Hutchinson, Colette Donaghy, Russell L. McLaughlin, Orla Hardiman   +11 more
doaj   +1 more source

Evaluation of Digital Technologies for Home‐Based Assessment in People With Amyotrophic Lateral Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Digital technologies hold promise for transforming healthcare by enhancing personalized treatments and offer valuable opportunities to improve patient care. Here, we evaluated several novel, self‐administered, home‐based, digital endpoints for their association with corresponding conventional standard clinical measures (primary) in ...
Arne Mueller, Vanessa Vallejo, Mónica Povedano Panadés, Orla Hardiman, Véronique Danel‐Brunaud, Senda Ajroud‐Driss, Philippe Couratier, Jeremy Shefner, Anna Gokey, Mike DiCesare, Erin Lennox, Jens Praestgaard, Lucie Brujin, Peggy Allred, Ram Miller   +14 more
wiley   +1 more source

Comprehensive clinical and genetic architecture of familial amyotrophic lateral sclerosis in China: A 15-year cohort study with 302 families

Neural Regeneration Research
The growing recognition of the role of genetics in the development of amyotrophic lateral sclerosis is evident. However, there has yet to be a comprehensive analysis of the clinical characteristics and genetics of familial amyotrophic lateral sclerosis ...
Wei Zheng, Lu Xu, Jinling Cai, Jinwen Hou, Lu Chen, Nan Zhang, Siyan Zhan, Dongsheng Fan, Ji He   +8 more
doaj   +1 more source

Elevated serum creatine kinase in the early stage of sporadic amyotrophic lateral sclerosis [PDF]

, 2019
Objective: To assess the changes of muscle-related biomarkers at the early stage of amyotrophic lateral sclerosis, and to confirm these findings in an experimental animal model.
Hashizume, Atsushi, Kishimoto, Yoshiyuki, Ito, Daisuke, Hirakawa, Akihiro, Katsuno, Masahisa, Hijikata, Yasuhiro, Iguchi, Yohei, Iida, Madoka, Yamada, Shinichiro, Moriyoshi, Hideyuki   +9 more
core   +1 more source

Eye-Tracking Assistive Technologies for Individuals with Amyotrophic Lateral Sclerosis [PDF]

, 2022
Amyotrophic lateral sclerosis, also known as ALS, is a progressive nervous system disorder that affects nerve cells in the brain and spinal cord, resulting in the loss of muscle control. For individuals with ALS, where mobility is limited to the movement
Zhang, Yinghui, Vien, Q., Morris-Cafiero, Haley, Muhammad-Sukki, Firdaus, Muhammad-Sukki, F., Edughele, H., Zhang, Y., Opoku Agyeman, M., Vien, Quoc-Tuan, Edughele, Hilary, Opoku Agyeman, Michael, Edughele, Hilary O, Morris-Cafiero, Haley; id_orcid, Opoku Agyeman, Michael; id_orcid   +13 more
core   +1 more source

Peripheral Neutrophil Activation and Extracellular Trap Formation in Amyotrophic Lateral Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
Markers of neutrophil activation are increased in plasma during ALS, and markers of NET formation associate with ALS survival. ABSTRACT Objectives Peripheral neutrophil levels in amyotrophic lateral sclerosis (ALS) inversely correlate with survival, suggesting a role for neutrophils in disease progression.
Lillia A. Baird, Haley McQuown, Jihyun Park, Samuel J. Teener, Ian F. Webber‐Davis, Andrew D. Carter, Dae‐Gyu Jang, Eva L. Feldman, Stephen A. Goutman, Benjamin J. Murdock   +9 more
wiley   +1 more source

Shared genetic link and causal inference between blood lipids, lipid-lowering drugs and amyotrophic lateral sclerosis

Neural Regeneration Research
Growing evidence suggests that abnormal lipid metabolism occurs in amyotrophic lateral sclerosis, even in the presymptomatic stage, implying an etiologic link.
Kailin Xia, Ninghao Huang, Yajun Wang, Gan Zhang, Lu Tang, Linjing Zhang, Minhao Yao, Zhonghua Liu, Tao Huang, Dongsheng Fan   +9 more
doaj   +1 more source

A mutation in dynein rescues axonal transport defects and extends the life span of ALS mice [PDF]

, 2005
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative condition characterized by motoneuron degeneration and muscle paralysis. Although the precise pathogenesis of ALS remains unclear, mutations in Cu/Zn superoxide dismutase (SOD1) account for
Dairin Kieran, Martin, J, Joanne Martin, Schiavo, G, Giampietro Schiavo (107907), Dick, JRT, Greensmith, L., Joanne Martin (11260388), Bohnert, S, Hafezparast, M., Elizabeth M.C. Fisher, Fisher, EMC, Linda Greensmith, Stephanie Bohnert (16066082), Martin, J., Majid Hafezparast (4461484), Fisher, E.M.C., James R T Dick (16066085), Majid Hafezparast, Greensmith, L, Linda Greensmith (252146), Giampietro Schiavo, Kieran, D., Bohnert, S., Stephanie Bohnert, James R.T. Dick, Dairin Kieran (7953794), Dick, J.R.T., Kieran, D, Hafezparast, M, Schiavo, G., Elizabeth M C Fisher (16062626)   +31 more
core   +1 more source

Sex‐Stratified Association of Regional Dopamine Transporter Binding With Disease Progression in Amyotrophic Lateral Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To clarify the clinical relevance of dopamine transporter single‐photon emission computed tomography (DAT‐SPECT) abnormalities in amyotrophic lateral sclerosis (ALS), with a prespecified focus on sex‐stratified associations with disease progression and short‐term prognosis.
Tomoya Kawazoe, Keizo Sugaya, Kentaro Hayashi, Keiko Hino, Yasuhiro Nakata, Kota Bokuda, Toshio Shimizu, Kazushi Takahashi   +7 more
wiley   +1 more source

The Omega-3 Fatty Acid Eicosapentaenoic Acid Accelerates Disease Progression in a Model of Amyotrophic Lateral Sclerosis [PDF]

, 2013
PMCID: PMC3631166This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are ...
Michael-Titus, A, Jayasinghe, M, Simon C. Dyall (404793), Biggio, M. L., Gladman, Stacy, Maria Luigia Biggio, Jayasinghe Maduka, Malaspina, A., Caterina Bendotti (202355), Pizzasegola Chiara, Simon C Dyall, Farhan Ullah (404792), Andrea Malaspina (315789), Biggio, ML, Pizzasegola, C, Stacy Gladman (404789), Pizzasegola, Chiara, Biggio Maria Luigia, Chiara Pizzasegola (404788), Gladman, S, Yip Ping K., Bendotti, C., Ullah, Farhan, Maria Luigia Biggio (404790), Bendotti, Caterina, Gladman Stacy, Ullah, F., Maduka Jayasinghe, Marino, M, Maduka Jayasinghe (404791), Dyall, SC, Malaspina, Andrea, Pizzasegola, C., Andrea Malaspina, Ullah Farhan, Chiara Pizzasegola, Ping K. Yip (247093), Dyall Simon C., Marianna Marino, Caterina Bendotti, Jayasinghe, M., Marino, Marianna, Marianna Marino (256589), Yip, P. K., Yip, PK, Bendotti, C, Malaspina Andrea, Gladman, S., Ullah, F, Marino Marianna, Michael-Titus, Adina, Bendotti Caterina, Adina Michael-Titus (404794), Jayasinghe, Maduka, Michael-Titus, A. T., Farhan Ullah, Ping K Yip, Biggio, Maria Luigia, Adina Michael-Titus, Dyall, Simon C; id_orcid, Stacy Gladman, Dyall, Simon, Michael-Titus Adina, Yip, Ping K, Malaspina, A, Marino, M.   +65 more
core   +2 more sources