Results 11 to 20 of about 995,258 (307)

Data-Driven SuStaIn Model of Disability Progression in Amyotrophic Lateral Sclerosis. [PDF]

Ann Clin Transl Neurol
ABSTRACT Objective To determine whether ordinal Subtype and Stage Inference (SuStaIn) applied to routine ALSFRS‐R item scores can identify reproducible disability progression patterns in amyotrophic lateral sclerosis (ALS) and provide clinically meaningful staging.
Milella G, Vacchiano V, Velucci V, Zoccolella S, Liguori R, Defazio G.   +5 more
europepmc   +2 more sources

Metabolic and Fluid Biomarkers Support Microglia Activation in Amyotrophic Lateral Sclerosis. [PDF]

Ann Clin Transl Neurol
ABSTRACT Amyotrophic lateral sclerosis is an incurable neurodegenerative disease involving motor neuron degeneration and metabolic and immune dysfunction. We combined clinical data, cerebrospinal fluid biomarkers and fluorodeoxyglucose positron emission tomography with magnetic resonance imaging to investigate the role of reactive microglia in disease ...
Zanovello M, Serani F, Bebeti A, Paredi F, Quadrio G, Fortuna A, Minicuci GM, Pegoraro E, Cagnin A, Cecchin D, Sorarù G.   +10 more
europepmc   +2 more sources

Molecular Imaging of Microglial Activation in Amyotrophic Lateral Sclerosis [PDF]

, 2012
There is growing evidence of activated microglia and inflammatory processes in the cerebral cortex in amyotrophic lateral sclerosis (ALS). Activated microglia is characterized by increased expression of the 18 kDa translocator protein (TSPO) in the brain
Philippe Corcia, Tauber, Clovis, Yann Venel, Nicolas Arlicot, Corcia, Philippe, Hommet, Caroline, Praline, Julien, Kassiou, Michael, Johnnie Vercoullie, Arlicot, Nicolas, Guilloteau, Denis, Catherine Roussel, Ribeiro, Maria-Joao, Caroline Hommet, Prunier, Caroline, Roussel, Catherine, Baulieu, Jean-Louis, Clovis Tauber, Guillaume Nicolas, Jean-Louis Baulieu, Julien Praline, Venel, Yann, Nicolas, Guillaume, Mickael Kassiou, Vercouillie, Johnny, Cottier, Jean-Philippe, Maria-Joao Ribeiro, Caroline Prunier, Jean-Philippe Cottier, Denis Guilloteau   +29 more
core   +2 more sources

Noninvasive ¹³C-octanoic acid breath test shows delayed gastric emptying in patients with amyotrophic lateral sclerosis [PDF]

, 1999
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder characterized by progressive loss of motor neurons. However, ALS has been recognized to also involve non-motor systems.
Folwaczny, Christian, Lochmüller, H., Müller-Felber, W., Schroeder, M., Riepl, R. L., Toepfer, Marcel, Pongratz, D.   +6 more
core   +1 more source

Characteristics of amyotrophic lateral sclerosis in Lebanon-a chart review [PDF]

, 2020
Objective: Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder primarily manifesting as motor deficits. It is caused by motor neuron death and leads to progressive disability and demise.
Doumiati, Hassan, Salameh, Johnny S., Ismail, Helen H., Malek, Elia Gebran   +3 more
core   +1 more source

Amyotrophic Lateral Sclerosis

, 2020
Chapter to be included in the volume Pragmatic Language Disorders: Complex and Underserved Populations, Ed. Louise Cummings, Springer, 2020. It reviews findings that have contributed to our understanding of pragmatic impairment in ALS.
Ceroni, Mauro, Bambini , Valentina
openaire   +3 more sources

Amyotrophic lateral sclerosis

The Lancet, 2022
Amyotrophic lateral sclerosis is a fatal CNS neurodegenerative disease. Despite intensive research, current management of amyotrophic lateral sclerosis remains suboptimal from diagnosis to prognosis. Recognition of the phenotypic heterogeneity of amyotrophic lateral sclerosis, global CNS dysfunction, genetic architecture, and development of novel ...
Feldman, E.L., Goutman, S.A., Petri, S., Mazzini, L., Savelieff, M.G., Shaw, P.J., Sobue, G.   +6 more
openaire   +4 more sources

G-CSF Prevents the Progression of Structural Disintegration of White Matter Tracts in Amyotrophic Lateral Sclerosis: A Pilot Trial [PDF]

, 2011
Background: The hematopoietic protein Granulocyte-colony stimulating factor (G-CSF) has neuroprotective and regenerative properties. The G-CSF receptor is expressed by motoneurons, and G-CSF protects cultured motoneuronal cells from apoptosis.
Tobias Warnecke, Schneider, A, Deppe Michael, Floel, A, Thomas Duning, Harald Kugel, Mohammadi Siawoosh, Katja Kolpatzik, Knecht Stefan, Schiffbauer, H, Wolf Rüdiger Schäbitz, Hagen Schiffbauer, Schäbitz Wolf Rüdiger, Duning Thomas, Kugel Harald, Knecht, S, Warnecke Tobias, Agnes Floel, Kolpatzik, K, Warnecke, T, Floel Agnes, Kugel, H, Schabitz, WR, Deppe, M, Kolpatzik Katja, Armin Schneider, Mohammadi, S, Michael Deppe, Duning, T, Schneider Armin, Stefan Knecht, Siawoosh Mohammadi, Schiffbauer Hagen   +32 more
core   +1 more source

A two-stage genome-wide association study of sporadic amyotrophic lateral sclerosis [PDF]

, 2009
The cause of sporadic amyotrophic lateral sclerosis (ALS) is largely unknown, but genetic factors are thought to play a significant role in determining susceptibility to motor neuron degeneration.
Sendtner, M., Ding, J., Guralnik, J., Sabatelli, M., Dunkley, T., Marinou, K., F. Valentino, Singleton, A, LA BELLA V, Shiao-Lin Lai, Zachary Simmons, D. J. Hunter, LA BELLA, Vincenzo, MANCARDI GL, Hardy, J., Bandinelli, S, Fisher, E.M., Wichmann, H.-E., Beck, M, SCHMIDT S, Carlesi, C, ORRELL RW, Lupoli ,S, CAPONNETTO C, Federica Lombardo, Kwee, L. C., SICILIANO, GABRIELE, Bandinelli ,S, Mancardi, GL, D. Hernandez, Arepalli ,S, Connor ,J, I. Rafferty, Kwee ,LC, Schymick, JC, Chanock ,SJ, Siciliano, G., Conte, Amelia, Bandinelli, S., F. Torri, Gieger, C, MANCARDI, GIOVANNI LUIGI, SCHYMICK J, J. Ding, Singleton ,A, Sabatelli ,M, Dunkley ,T, KASPERAVICIUTE D, Hunter ,DJ, Simmons ,Z, Lupoli, S., Schmidt ,S, Beck ,M, Giannini, F., Rothstein ,J, Carlesi, C., Pioro, EP, CHANOCK SJ, PIORO E, Oddone, E.Z., Macciardi, F., S. Arepalli, VALENTINO F, Lai, S.-L., B. J. Traynor, Sara Lupoli, Mandrioli, J, Stefania Battistini, Schymick, J. C., STEPHAN D, FUNG H, Kasperaviciute, D., Gibbs, J.R., Mancardi ,GL, CARLESI, CECILIA, M. Sendtner, H. Fung, Arepalli, S, Guralnik, J, Mandrioli ,J, Battistini ,S, Lupoli, S, MORA G, KWEE L, Mario Sabatelli, KWEE LC, Ilaria Bartolomei, Schymick,JC, Hardy ,J, Sendtner, M, Adriano Chiò, Sola, P, Dena Hernandez, LAI S, Kwee, LC, Ding, J.H., Battistini, S., Wichmann, H. E., Crews ,C, MUTANI R, Salvi, F, Simmons, Z, J. Mandrioli, Carlesi ,C, Calvo, A., SABATELLI M, Sampath Arepalli, BATTISTINI S, Rothstein, J, NALLS M, A. Calvo, Salvi ,F, Scholz, S. W., Jabonka ,S, ODDONE E, FISHER E, TRAYNOR BJ, CHIO' A, Sola ,P, Chanock, S.J., K. Marinou, Valentino, F, Britton, A, Travis Dunkley, Andrew Singleton, Fisher, E. M., Ferrucci, L, Hunter, DJ, C. Crews, Gibbs, JR, F. Salvi, CONTE A, HARDY J, Mancardi, G.L., Dunkley, T, FUNG HC, L. Ferrucci, Dalia Kasperaviciute, Luigi Ferrucci, Lucie Bruijn, BERGER S, Beck, M., Scholz,SW, Fisher, EM, Sola, P., TORRI F, Lombardo, F, BARTOLOMEI I, Nalls, M, Restagno,G, Sonja W. Scholz, Amelia Conte, S. Bandinelli, Salvi, F., Restagno, G, Thomas ,G, Conte, A., Sendtner ,M, Z. Simmons, SENDTNER M, Mora, G, Macciardi, F, C. Caponnetto, Michael Nalls, Tedeschi ,G, G. Restagno, TRAYNOR B., LOMBARDO F, Scholz, S.W., Crews, C, L. Bruijn, Lai ,SL, Ding ,J, James Connor, Mutani, R., Caponnetto, C., Wichmann ,HE, E. P. Pioro, Hernandez ,D, H. E. Wichmann, Ferrucci ,L, Monsurro, M.R., Britton ,A, SICILIANO G, A. Conte, Jabonka, S, Tedeschi, G, Stephan, D.A., John Hardy, Rafferty, I., DING J, Gabriele Mora, CHIÒ A, P. Sola, Erik P. Pioro, Chanock, SJ, Kalliopi Marinou, Stephen J. Chanock, Mora ,G, Stephan, D. A., TEDESCHI G, Chio, A., Connor, J, Sibylle Jabonka, Traynor, B.J., Nalls ,M, David J. Hunter, Gibbs ,JR, BECK M, MONSURRO', Maria Rosaria, Bruijn, L., S. Berger, Pioro, E.P., H. C. Fung, FERRUCCI L, RESTAGNO G, LAI SL, Hernandez, D, F. Lombardo, J. Hardy, Jeffrey Rothstein, Ding, J, J. C. Schymick, Restagno, G., Valentino, F., Stefania Bandinelli, Gieger ,C, Lai, SL, Giovanni Luigi Mancardi, Rafferty, I, R. Mutani, C. Gieger, HUNTER D, Eugene Z. Oddone, Oddone, E. Z., Maria Rosaria Monsurrò, Ferrucci, L., D. Kasperaviciute, Vincenzo La Bella, ORRELL R, S. Battistini, G. Tedeschi, Fung, HC, Pioro, E. P., ROTHSTEIN J, CHANOCK S, Connor, J., Thomas, G., Arepalli, S., A. Chiò, Oddone, EZ, TEDESCHI, Gioacchino, Bryan J. Traynor, S. Lai, Kwee, L.C., Mutani, R, La Bella, V., TALBOT K, A. Britton, Hunter, D.J., Orrell, R.W., Sabatelli, Mario, J. Guralnik, Bartolomei ,I, M. R. Monsurrò, Gioacchino Tedeschi, Gibbs, J. R., D. A. Stephan, Stephen Berger, SIMMONS Z, Torri, F, Singleton, A., Claudia Caponnetto, Rafferty ,I, GuralMnik ,J, GIBBS JR, CAPONETTO C, Cecilia Carlesi, RAFFERTY I, Schymick, J.C., E. Z. Oddone, Roberto Mutani, N. Washecka, Traynor, B. J., Traynor,BJ, Tedeschi, G., J. R. Gibbs, Marinou, K, Chiò, A, Fabio Giannini, Kasperaviciute ,D, GIEGER C, MARINOU K, Michael Sendtner, BRITTON A, DUNKLEY T, Dietrich A. Stephan, Gieger, C., Mancardi, G. L., S. L. Lai, Rothstein, J., CREWS C, Talbot, K., Simmons, Z., M. Sabatelli, JABONKA S, I. Bartolomei, Cynthia Crews, Hernandez, D., Berger ,S, BANDINELI S, Mora, G., Crews, C., G. L. Mancardi, Washecka ,N, WICHMANN H, Gabriella Restagno, Stephan, DA, La Bella, V, PIORO EP, FISHER EM, Wichmann, HE, H. Erich Wichmann, Lombardo ,F, Macciardi ,F, Lai, S.L., CALVO A, V. La Bella, V. L. Bella, Fung ,HC, Jinhui Ding, Kasperaviciute, D, Fisher ,EM, SCHYMICK JC, SOLA P, Bartolomei, I., Lydia Coulter Kwee, J. Raphael Gibbs, GURALNIK J, Thomas, G, Nicole Washecka, Fung, H.-C., Jessica Mandrioli, BATTISTINI, STEFANIA, M. Beck, Orrell, R. W., T. Dunkley, Hon-Chung Fung, D. Hunter, CONNOR J, Jack Guralnik, Mandrioli, J., J. Connor, Jennifer C. Schymick, R. W. Orrell, SINGLETON A, Schmidt, S., Schmidt, S, Conte, A, S. Jabonka, Elizabeth M. Fisher, Hardy, J, Angela Britton, Lombardo, F., Talbot, K, Kevin Talbot, Bruijn ,L, Giannini ,F, A. Singleton, Chanock, S. J., Stephan ,DA, Calvo, A, Pioro ,EP, SALVI F, Battistini, S, Berger, S, WICHMANN HE, MANDRIOLI J, Nalls, M., Scholz, SW, Federica Torri, SCHOLZ SW, Sabatelli, M, Traynor, BJ, Fabrizio Salvi, Jabonka, S., Berger, S., G. Siciliano, MANCARDI G, Calvo ,A, Bruijn, L, Orrell ,RW, Marcus Beck, MACCIARDI F, K. Talbot, HUNTER DJ, Siciliano, G, Washecka, N, G. Mora, Mutani ,R, Fabio Macciardi, S. J. Chanock, C. Carlesi, SCHOLZ S, Conte ,A, S. W. Scholz, Christian Gieger, Caponnetto, C, VALENTINO, Francesca, Siciliano ,G, Bartolomei, I, Talbot ,K, HERNANDEZ D, E. M. Fisher, GIANNINI, FABIO, WASHECKA N, STEPHAN DA, S. Lupoli, BRUIJN L, F. Giannini, Gabriele Siciliano, Monsurrò ,MR, Fung, H.C., Richard W. Orrell, Silke Schmidt, Oddone ,EZ, Orrell, RW, AREPALLI S, L. C. Kwee, Gilles Thomas, Torri, F., M. Nalls, Ian Rafferty, ODDONE EZ, CARLESI C, Francesca Valentino, Marinou ,K, Giannini, F, Hunter, D. J., GIANNINI F, J. Rothstein, THOMAS J, G. Thomas, THOMAS G, BANDINELLI S, Andrea Calvo, Patrizia Sola, LUPOLI S, Washecka, N., Chiò,A, Caponnetto ,C, GIBBS J, Torri ,F, Britton, A., F. Macciardi, S. Schmidt, Monsurrò, MR, Monsurro, M. R., MONSURRÒ MR, Mutani, Roberto, Calvo, Andrea, Chio', Adriano   +461 more
core   +2 more sources

The Peroxisome Proliferator-activated Receptor γ (PPARγ) Controls Natural Protective Mechanisms against Lipid Peroxidation in Amyotrophic Lateral Sclerosis [PDF]

, 2012
Recent evidence highlights the peroxisome proliferator-activated receptors (PPARs) as critical neuroprotective factors in several neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS). To gain new mechanistic insights into the role of
Maggi, Adriana, L. Brambilla, Benedusi, Valeria, Brambilla, Liliana, A. Maggi, V. Benedusi, Martorana, Francesca, F. Martorana, Rossi, Daniela   +8 more
core   +1 more source