Results 51 to 60 of about 348,117 (269)

Age-related cognitive effects of the COVID-19 pandemic restrictions and associated mental health changes in Germans

Scientific Reports, 2022
Restrictive means to reduce the spread of the COVID-19 pandemic have not only imposed broad challenges on mental health but might also affect cognitive health.
Inga Menze, Patrick Mueller, Notger G. Mueller, Marlen Schmicker   +3 more
doaj   +1 more source

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

Long-term dynamics of aberrant neuronal activity in awake Alzheimer’s disease transgenic mice

Communications Biology, 2021
To advance our understanding of aberrant neuronal activity in Alzheimer’s disease (AD) Korzhova et al. use in vivo two-photon calcium imaging to record activity from cortical neurons of awake APPPS1 transgenic mice over four weeks, during the early phase
V. Korzhova, P. Marinković, J. Rudan Njavro, P. M. Goltstein, F. Sun, S. Tahirovic, J. Herms, S. Liebscher   +7 more
doaj   +1 more source

Effect of terahertz irradiation on DNA damage repair in living cells

FEBS Open Bio, EarlyView.
We investigated the effect of terahertz (THz) wave irradiation on DNA double‐strand break (DSB) repair in living cells. We found that THz irradiation enhanced DSB repair at specific frequencies, whereas heat treatment inhibited it, indicating that this effect is nonthermal and frequency‐specific.
Yuya Ueno, Shota Yamazaki, Hiromichi Hoshina, Masahiko Harata   +3 more
wiley   +1 more source

Characterization and clinical use of inflammatory cerebrospinal fluid protein markers in Alzheimer’s disease

Alzheimer’s Research & Therapy, 2018
Background Neuroinflammation has gained increasing attention as a potential contributing factor in Alzheimer’s disease (AD) pathology. A clinical cerebrospinal fluid biomarker capable of monitoring this process during the course of the disease has yet to
Frederic Brosseron, Andreas Traschütz, Catherine N. Widmann, Markus P. Kummer, Pawel Tacik, Francesco Santarelli, Frank Jessen, Michael T. Heneka   +7 more
doaj   +1 more source

Lysosomal lipid alterations caused by glucocerebrosidase deficiency promote lysosomal dysfunction, chaperone-mediated-autophagy deficiency, and alpha-synuclein pathology

npj Parkinson's Disease, 2022
Mutations in the GBA gene that encodes the lysosomal enzyme β-glucocerebrosidase (GCase) are a major genetic risk factor for Parkinson’s disease (PD).
Alba Navarro-Romero, Irene Fernandez-Gonzalez, Jordi Riera, Marta Montpeyo, Merce Albert-Bayo, Tresa Lopez-Royo, Pablo Castillo-Sanchez, Clara Carnicer-Caceres, Jose Antonio Arranz-Amo, Laura Castillo-Ribelles, Eddie Pradas, Josefina Casas, Miquel Vila, Marta Martinez-Vicente   +13 more
doaj   +1 more source

Aging Is a Key Driver for Adult Acute Myeloid Leukemia

Aging and Cancer, EarlyView.
Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley   +1 more source

Metallothionein and neurodegenerative diseases

Neural Regeneration Research
Neurodegenerative diseases, which mainly include Alzheimer’s disease, Parkinson’s disease, amyotrophic lateral sclerosis, Wilson’s disease, and Huntington’s disease, are a group of disorders characterized by loss of neurons in the brain and spinal cord. However, the underlying pathogenetic mechanisms of these disorders remain unclear.
Yufeng Cheng, Yujia Zhao, Ce Chen, Feng Zhang   +3 more
openaire   +2 more sources

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Sex-, gender- and ethnically-sensitive aspects of psychosocial interventions for people living with dementia and BPSD: A protocol for a participatory umbrella review

BMJ Open
Introduction Behavioural and psychological symptoms of dementia (BPSD) affect up to 80% of people with dementia and pose significant challenges in the context of care.
Christina Manietta, Martina Roes, Mike Rommerskirch-Manietta, Kübra Altinok, Simone Anna Felding, Gizem Yigit, Elena Michel   +6 more
doaj   +1 more source