Results 51 to 60 of about 413,699 (314)

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Characterization and clinical use of inflammatory cerebrospinal fluid protein markers in Alzheimer’s disease

Alzheimer’s Research & Therapy, 2018
Background Neuroinflammation has gained increasing attention as a potential contributing factor in Alzheimer’s disease (AD) pathology. A clinical cerebrospinal fluid biomarker capable of monitoring this process during the course of the disease has yet to
Frederic Brosseron, Andreas Traschütz, Catherine N. Widmann, Markus P. Kummer, Pawel Tacik, Francesco Santarelli, Frank Jessen, Michael T. Heneka   +7 more
doaj   +1 more source

Erythropoietin modulates hepatic inflammation, glucose homeostasis, and soluble epoxide hydrolase and epoxides in high‐fat diet‐induced obese mice

FEBS Open Bio, EarlyView.
Erythropoietin administration suppresses hepatic soluble epoxide hydrolase (sEH) expression, leading to increased CYP‐derived epoxides. This is associated with a shift in hepatic macrophage polarization characterized by reduced M1 markers and increased M2 markers, along with reduced hepatic inflammation, suppressed hepatic lipogenesis, and attenuated ...
Takeshi Goda, Satoru Sugimoto, Chiharu Cho, Madoka Konishi, Nozomi Inoue, Satoshi Miyagaki, Yasuhiro Kawabe, Takuro Okamura, Masahide Hamaguchi, Hisakazu Nakajima, Michiaki Fukui, Masakazu Shinohara, Tomoko Iehara   +12 more
wiley   +1 more source

Influence of sleep disruption on protein accumulation in neurodegenerative diseases

, 2022
Abnormal accumulation of disease proteins in the central nervous system is a neuropathological feature in neurodegenerative disorders. Recently, a growing body of evidence has supported a role of disruption of the sleep-wake cycle in disease development,
Li, Jiada, Wang, Xiying, Wang, Rui
core  

The Impact of Demographic and Clinical Factors on the Quality of Life in Patients with Neurodegenerative Cerebellar Ataxias

, 2023
In neurodegenerative cerebellar ataxias, not only ataxia but also extra-cerebellar signs have a significant impact on patients’ health related to quality of life (HRQoL).
Gorica Marić, Elka Stefanova, Katarina Đurđević, Milutin Kostić, Tatjana Pekmezović, Nataša Dragašević-Mišković, Olivera Tamaš, Andona Milovanović, Biljana Salak Đokić   +8 more
core   +1 more source

Mitochondrial complex I inhibition enhances astrocyte responsiveness to pro-inflammatory stimuli

Scientific Reports
Inhibition of the mitochondrial oxidative phosphorylation (OXPHOS) system can lead to metabolic disorders and neurodegenerative diseases. In primary mitochondrial disorders, reactive astrocytes often accompany neuronal degeneration and may contribute to ...
Lena Wischhof, Amal John Mathew, Lorenzo Bonaguro, Marc Beyer, Dan Ehninger, Pierluigi Nicotera, Daniele Bano   +6 more
doaj   +1 more source

Age-related cognitive effects of the COVID-19 pandemic restrictions and associated mental health changes in Germans

Scientific Reports, 2022
Restrictive means to reduce the spread of the COVID-19 pandemic have not only imposed broad challenges on mental health but might also affect cognitive health.
Inga Menze, Patrick Mueller, Notger G. Mueller, Marlen Schmicker   +3 more
doaj   +1 more source

Establishing an assay to evaluate d‐amino acid oxidase enzyme kinetics and inhibition using WST‐8 redox dye

FEBS Open Bio, EarlyView.
This study investigated a novel WST‐8‐based assay for evaluating d‐Amino acid oxidase (DAO) inhibitors. We confirmed its effectiveness using known inhibitors and found that uremic toxins possess relatively weak inhibitory activity compared to existing drugs.
Kahoko Miyake, Yuki Enoki, Yuka Nakazawa, Kazuaki Taguchi, Kazuaki Matsumoto   +4 more
wiley   +1 more source

The Role of Selenium in Neurodegenerative Diseases

, 2017
© 2017 Elsevier Inc. All rights reserved. Selenium is an essential micronutrient, imparting a biological function as a key component of the 21st amino acid, selenocysteine.
Cardoso, BR, Dominic J. Hare, Bush, AI, Hare, DJ, Bárbara R. Cardoso, Ashley I. Bush   +5 more
core   +1 more source

Long-term dynamics of aberrant neuronal activity in awake Alzheimer’s disease transgenic mice

Communications Biology, 2021
To advance our understanding of aberrant neuronal activity in Alzheimer’s disease (AD) Korzhova et al. use in vivo two-photon calcium imaging to record activity from cortical neurons of awake APPPS1 transgenic mice over four weeks, during the early phase
V. Korzhova, P. Marinković, J. Rudan Njavro, P. M. Goltstein, F. Sun, S. Tahirovic, J. Herms, S. Liebscher   +7 more
doaj   +1 more source