Results 61 to 70 of about 413,699 (314)

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source

Autophagy in ageing and ageing-related neurodegenerative diseases

, 2021
Autophagy is a catabolic mechanism that allows cells to deliver cytoplasmic contents to lysosomes for degradation to maintain energy homeostasis and to protect cells against stress. Autophagy has been directly linked to neurodegeneration and ageing by an
Park, So Jung, Karabiyik, Cansu, Frake, Rebecca A., Pavel, Mariana, Rubinsztein, David C.   +4 more
core  

CSPα in neurodegenerative diseases

Frontiers in Aging Neuroscience, 2022
Adult-onset neuronal ceroid lipofuscinosis (ANCL) is a rare neurodegenerative disease characterized by epilepsy, cognitive degeneration, and motor disorders caused by mutations in the DNAJC5 gene. In addition to being associated with ANCL disease, the cysteine string proteins α (CSPα) encoded by the DNAJC5 gene have been implicated in several ...
Liqin Huang, Zhaohui Zhang
openaire   +3 more sources

Chr:17q21.31 locus risk haplotype H1 susceptibility to ferroptosis is mediated by endolysosomal pathway

Cell Death and Disease
Human chr:17q21.31 locus is a complex genomic region of high linkage disequilibrium with two main haplotypes, named H1 and H2. The H1 haplotype is genetically associated with a wide spectrum of neurodegenerative diseases (NDs), including tauopathies and ...
Eldem Sadikoglou, Daniel Domingo-Fernández, Natalia Savytska, Noemia Fernandes, Patrizia Rizzu, Anastasia Illarionova, Tabea Strauß, Sigrid C. Schwarz, Alpha Kodamullil, Günter U. Höglinger, Ashutosh Dhingra, Thomas Gasser, Peter Heutink   +12 more
doaj   +1 more source

A novel CHCHD10 mutation implicates a Mia40‐dependent mitochondrial import deficit in ALS

EMBO Molecular Medicine, 2018
CHCHD10 mutations are linked to amyotrophic lateral sclerosis, but their mode of action is unclear. In a 29‐year‐old patient with rapid disease progression, we discovered a novel mutation (Q108P) in a conserved residue within the coiled‐coil‐helix‐coiled‐
Carina Lehmer, Martin H Schludi, Linnea Ransom, Johanna Greiling, Michaela Junghänel, Nicole Exner, Henrick Riemenschneider, Julie van der Zee, Christine Van Broeckhoven, Patrick Weydt, Michael T Heneka, Dieter Edbauer   +11 more
doaj   +1 more source

Highly efficient intercellular spreading of protein misfolding mediated by viral ligand-receptor interactions

Nature Communications, 2021
Pathologic protein aggregates associated with neurodegenerative diseases have the ability to transmit to unaffected cells via extracellular vesicles or direct cell-to-cell contact. Here, Liu et al.
Shu Liu, André Hossinger, Stefanie-Elisabeth Heumüller, Annika Hornberger, Oleksandra Buravlova, Katerina Konstantoulea, Stephan A. Müller, Lydia Paulsen, Frederic Rousseau, Joost Schymkowitz, Stefan F. Lichtenthaler, Manuela Neumann, Philip Denner, Ina M. Vorberg   +13 more
doaj   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Brainstem : neglected locus in neurodegenerative diseases

, 2011
The most frequent neurodegenerative diseases (NDs) are Alzheimer’s disease (AD), Parkinson’s disease (PD), and frontotemporal lobar degeneration associated with protein TDP-43 (FTLD–TDP).
Lea Tenenholz Grinberg, Lea T Grinberg, Helmut Heinsen, Udo eRueb, Udo Rueb, Tenenholz Grinberg, Lea, Heinsen, Helmut, Rüb, Udo, Helmut eHeinsen   +8 more
core   +1 more source

Nuance of inward rectifying potassium (Kir) channel dysfunctions in neurodegenerative diseases

, 2023
Neurodegenerative disorders are highly prevalent and diverse in nature. Their manifestation largely depends on the cell types involved, with aberrant inflammatory episodes progressively inducing a constellation of phenotypes that are classified into ...
Linlin Ma, Benjamin Garland, Ma, L, Garland, B   +3 more
core   +1 more source

Identifying future research priorities for diversity-sensitive psychosocial interventions to manage dementia-related symptoms (GenderDem): protocol for a priority setting partnership study

BMJ Open
Introduction Gender, sex and ethnicity-sensitive approaches to psychosocial interventions for behavioural and psychological symptoms of dementia have been under-represented in the literature.
Christina Manietta, Martina Roes, Mike Rommerskirch-Manietta, Kübra Altinok, Simone Anna Felding, Gizem Yigit, Elena Michel   +6 more
doaj   +1 more source