Results 51 to 60 of about 211,053 (311)

Fc-Galactosylation of Human Immunoglobulin Gamma Isotypes Improves C1q Binding and Enhances Complement-Dependent Cytotoxicity

Frontiers in Immunology, 2017
Binding of the complement component C1q to the CH2 domain of antigen-bound immunoglobulin gamma (IgG) activates the classical complement pathway and depends on its close proximity to Fc fragments of neighboring antibodies. IgG subclasses contain a highly
Benjamin Peschke, Christian W. Keller, Patrick Weber, Isaak Quast, Isaak Quast, Jan D. Lünemann, Jan D. Lünemann   +6 more
doaj   +1 more source

Dopamine receptor D3 signalling in astrocytes promotes neuroinflammation

, 2019
Publisher Copyright: © 2019 The Author(s).Background: Neuroinflammation constitutes a pathogenic process leading to neurodegeneration in several disorders, including Alzheimer's disease, Parkinson's disease (PD) and sepsis. Despite microglial cells being
Elgueta, Daniela, Bono, María Rosa, Universidad San Sebastián, Montoya, Andro, Matus, Soledad, Campos, Javier, Falcón, Paulina, Pacheco, Rodrigo, Chovar, Ornella, Alfaro, Iván   +9 more
core   +1 more source

Cellulose ether treatment inhibits amyloid beta aggregation, neuroinflammation and cognitive deficits in transgenic mouse model of Alzheimer’s disease

, 2023
Alzheimer’s disease (AD) is an incurable, progressive and devastating neurodegenerative disease. Pathogenesis of AD is associated with the aggregation and accumulation of amyloid beta (Aβ), a major neurotoxic mediator that triggers neuroinflammation and ...
Ali, Tahir,, Hallbeck, Martin,, Antonia N. Klein, Hermann M. Schatzl, Mukherjee, Priyanka Ganguli, Klein, Antonia N., Doh-ura, Katsumi, Tahir Ali, Klein, Antonia N.,, McDonald, Keegan, Keegan McDonald, Lovisa Johansson, Doh-ura, Katsumi,, Sabine Gilch, Schatzl, Hermann M.,, Schatzl, Hermann M., Johansson, Lovisa,, Ali, Tahir, Gilch, Sabine, Priyanka Ganguli Mukherjee, Mukherjee, Priyanka Ganguli,, Martin Hallbeck, Katsumi Doh-ura, McDonald, Keegan,, Hallbeck, Martin, Johansson, Lovisa, Gilch, Sabine,   +26 more
core   +1 more source

Using antifibrinolytics to tackle neuroinflammation [PDF]

, 2020
Plasmin is generally known as a promotor of inflammation. Recent advancement suggests that it has a complex role as immunity modulator. Pharmacological inhibition of plasmin production and activity has been proven to improve neurological outcomes in ...
Atsev, Stanimir, Tomov, Nikola Stefanov
core   +2 more sources

NEUROINFLAMMATION [PDF]

International Journal of Neuroscience Research, 2021
Inflammation is a complex process, mediated by cellular and molecular mechanisms caused by a response to a tissue damage from an aggressive agent, whether if biological, chemical or physical origin. This process occurs, ultimately, with the purpose of promoting defense, repair and tissue regeneration.
openaire   +1 more source

Angiotensin-II drives changes in microglia–vascular interactions in rats with heart failure

Communications Biology
Activation of microglia, the resident immune cells of the central nervous system, leading to the subsequent release of pro-inflammatory cytokines, has been linked to cardiac remodeling, autonomic disbalance, and cognitive deficits in heart failure (HF ...
Ferdinand Althammer, Ranjan K. Roy, Matthew K. Kirchner, Yuval Podpecan, Jemima Helen, Shaina McGrath, Elba Campos Lira, Javier E. Stern   +7 more
doaj   +1 more source

Chronic neuroinflammation during aging leads to cholinergic neurodegeneration in the mouse medial septum

, 2023
Background: Low-grade, chronic inflammation in the central nervous system characterized by glial reactivity is one of the major hallmarks for aging-related neurodegenerative diseases like Alzheimer’s disease (AD). The basal forebrain cholinergic neurons (
Muench, Gerald (R12224), Rossetti, Ilaria (S35998), Niedermayer, Garry (R18734), Gamage, Rashmi (S35161), Gyengesi, Erika (R17270), Buskila, Yossi (R16966)   +5 more
core   +1 more source

Comparative Evaluation of Hemodiafiltration, Hemoperfusion, and Standard Hemodialysis on Efficacy, Inflammatory Control, Dialysis Adequacy, and Safety in End‐Stage Renal Disease: A Prospective Observational Study

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Chronic micro‐inflammation in patients with end‐stage renal disease (ESRD) is a significant driver of cardiovascular complications and diminished quality of life. While standard hemodialysis (SHD) effectively manages small‐molecule clearance, its ability to remove medium‐to‐large uremic toxins—the primary catalysts of systemic ...
Hongwei Zuo, Weisi Dai, Jie Mao, Mei Ye, Xingshan Lu, Xiaocui Zhang   +5 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Maternal separation differentially modulates early pathology by sex in 5xFAD Alzheimer’s disease-transgenic mice

Brain, Behavior, & Immunity - Health, 2023
Alzheimer’s disease (AD) is the most common neurodegenerative disease. Most cases of AD are considered idiopathic and likely due to a combination of genetic, environmental, and lifestyle-related risk factors.
M.G. Garcia, A. Paulus, S. Vázquez-Reyes, O. Klementieva, G.K. Gouras, S. Bachiller, T. Deierborg   +6 more
doaj   +1 more source