Results 31 to 40 of about 211,053 (311)

Neuroinflammation as a Key Driver of Secondary Neurodegeneration Following Stroke?

, 2021
Ischaemic stroke involves the rapid onset of focal neurological dysfunction, most commonly due to an arterial blockage in a specific region of the brain.
Lin Kooi Ong, Ong, Lin Kooi, Shannon M. Stuckey, Lyndsey E. Collins-Praino, Collins-Praino, Lyndsey E., Stuckey, Shannon M., Renée J. Turner, Turner, Renee J.   +7 more
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PPARs in Neuroinflammation [PDF]

PPAR Research, 2008
Welcome to this special issue of PPAR Research dedicated to “PPARs in Neuroinflammation.” The central nervous system (CNS) was once thought to be an immune-privileged site void of significant inflammation. However, it is now clear that activated peripheral immune cells are capable or entering and functioning within the CNS. In addition, resident immune
Paul D. Drew, Michael K. Racke
openaire   +3 more sources

[18F]DPA-714: Direct Comparison with [11C]PK11195 in a Model of Cerebral Ischemia in Rats [PDF]

, 2013
Purpose: Neuroinflammation is involved in several brain disorders and can be monitored through expression of the translocator protein 18 kDa (TSPO) on activated microglia.
Banister, S D, Julyan, P, Rothwell, N J, Alison Smigova (281869), Galea, James, Cawthorne, Christopher, Wilkinson, S M, Christian Prenant (281864), Herholz, K; id_orcid, Renaud Maroy (281866), Herholz, Karl, Michael Kassiou, Wilkinson, Shane M, Peter Julyan (281871), Maroy, Renaud, Gavin Brown, Samuel D Banister, Boutin, Hervé, Banister, Samuel D, Greenhalgh, A D, Wilkinson, Shane M., Karl Herholz, Prenant, Christian, Karl Herholz (281875), Boutin, H, Hervé Boutin (281863), Michael Kassiou (281876), Hervé Boutin, Christopher Cawthorne, Rothwell, Nancy J., Brown, G, Nancy J. Rothwell (281877), Banister, Samuel D., Kassiou, M, James Galea (281867), Alison Smigova, Julyan, Peter, Brown, Gavin, Smigova, Alison, Smigova, A, Andrew D. Greenhalgh (281868), Gavin Brown (281874), James Galea, Kassiou, Michael, Rothwell, Nancy J, Christian Prenant, Samuel D. Banister (281873), Christopher Cawthorne (281870), Renaud Maroy, Maroy, R, Peter Julyan, Prenant, C, Greenhalgh, Andrew D., Greenhalgh, Andrew D, Shane M. Wilkinson (281872), Boutin, Hervé; id_orcid, Andrew D Greenhalgh, Cawthorne, C, Nancy J Rothwell, Galea, J, Shane M Wilkinson   +60 more
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Imidazopyridazine Acetylcholinesterase Inhibitors Display Potent Anti-Proliferative Effects in the Human Neuroblastoma Cell-Line, IMR-32

Molecules, 2021
Imidazo[1,2-b]pyridazine compounds are a new class of promising lead molecules to which we have incorporated polar nitro and amino moieties to increase the scope of their biological activity.
Rakesh Kumar Sharma, Manisha Singh, Khagendra Ghimeray, Pinky Juneja, Gagan Dev, Sridhar Pulavarthi, Sabbasani Rajasekhara Reddy, Ravi Shankar Akundi   +7 more
doaj   +1 more source

Estrogens, Neuroinflammation, and Neurodegeneration [PDF]

Endocrine Reviews, 2016
Inflammatory activation of microglia is a hallmark of several disorders of the central nervous system. In addition to protecting the brain against inflammatory insults, microglia are neuroprotective and play a significant role in maintaining neuronal connectivity, but the prolongation of an inflammatory status may limit the beneficial functions of ...
VILLA, ALESSANDRO MARIA GIOVANNI, VEGETO, ELISABETTA, A. Poletti, MAGGI, ADRIANA CATERINA   +3 more
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APOE in the bullseye of neurodegenerative diseases: impact of the APOE genotype in Alzheimer’s disease pathology and brain diseases

Molecular Neurodegeneration, 2022
ApoE is the major lipid and cholesterol carrier in the CNS. There are three major human polymorphisms, apoE2, apoE3, and apoE4, and the genetic expression of APOE4 is one of the most influential risk factors for the development of late-onset Alzheimer's ...
Rosalía Fernández-Calle, Sabine C. Konings, Javier Frontiñán-Rubio, Juan García-Revilla, Lluís Camprubí-Ferrer, Martina Svensson, Isak Martinson, Antonio Boza-Serrano, José Luís Venero, Henrietta M. Nielsen, Gunnar K. Gouras, Tomas Deierborg   +11 more
doaj   +1 more source

Neuroinflammation in Alzheimer's disease [PDF]

The Lancet Neurology, 2015
Increasing evidence suggests that Alzheimer's disease pathogenesis is not restricted to the neuronal compartment, but includes strong interactions with immunological mechanisms in the brain. Misfolded and aggregated proteins bind to pattern recognition receptors on microglia and astroglia, and trigger an innate immune response characterised by release ...
Heneka, Michael T, Carson, Monica J, El Khoury, Joseph, Landreth, Gary E, Brosseron, Frederic, Feinstein, Douglas L, Jacobs, Andreas H, Wyss-Coray, Tony, Vitorica, Javier, Ransohoff, Richard M, Herrup, Karl, Frautschy, Sally A, Finsen, Bente, Brown, Guy C, Verkhratsky, Alexei, Yamanaka, Koji, Koistinaho, Jari, Latz, Eicke, Halle, Annett, Petzold, Gabor C, Town, Terrence, Morgan, Dave, Shinohara, Mari L, Perry, V Hugh, Holmes, Clive, Bazan, Nicolas G, Brooks, David J, Hunot, Stéphane, Joseph, Bertrand, Deigendesch, Nikolaus, Garaschuk, Olga, Boddeke, Erik, Dinarello, Charles A, Breitner, John C, Cole, Greg M, Golenbock, Douglas T, Kummer, Markus P   +36 more
openaire   +14 more sources

Fully automated segmentation of the cervical cord from T1-weighted MRI using PropSeg: Application to multiple sclerosis

NeuroImage: Clinical, 2016
Spinal cord (SC) atrophy, i.e. a reduction in the SC cross-sectional area (CSA) over time, can be measured by means of image segmentation using magnetic resonance imaging (MRI).
Marios C. Yiannakas, Ahmed M. Mustafa, Benjamin De Leener, Hugh Kearney, Carmen Tur, Daniel R. Altmann, Floriana De Angelis, Domenico Plantone, Olga Ciccarelli, David H. Miller, Julien Cohen-Adad, Claudia A.M. Gandini Wheeler-Kingshott   +11 more
doaj   +1 more source

Early-life stress elicits peripheral and brain immune activation differently in wild type and 5xFAD mice in a sex-specific manner

Journal of Neuroinflammation, 2022
Background The risk of developing Alzheimer’s disease (AD) is modulated by genetic and environmental factors. Early-life stress (ELS) exposure during critical periods of brain development can impact later brain function and health, including increasing ...
S. Bachiller, I. Hidalgo, M. G. Garcia, A. Boza-Serrano, A. Paulus, Q. Denis, C. Haikal, O. Manouchehrian, O. Klementieva, J. Y. Li, C. J. Pronk, G. K. Gouras, T. Deierborg   +12 more
doaj   +1 more source

Structural and Functional Alterations in Visual Pathway After Optic Neuritis in MOG Antibody Disease: A Comparative Study With AQP4 Seropositive NMOSD

Frontiers in Neurology, 2021
Background: Optic neuritis (ON) is an important clinical manifestation of neuromyelitis optic spectrum disease (NMOSD). Myelin oligodendrocyte glycoprotein (MOG) antibody-related and aquaporin 4 (AQP4) antibody-related ON show different disease patterns.
Chenyang Gao, Zhizheng Zhuo, Yunyun Duan, Yajun Yao, Lei Su, Xinghu Zhang, Tian Song   +6 more
doaj   +1 more source