Results 31 to 40 of about 220,080 (264)

Diesel exhaust impairs TREM2 to dysregulate neuroinflammation

, 2020
BACKGROUND: Air pollution has been linked to neurodegenerative diseases, including Alzheimer's disease (AD), and the underlying neuroimmune mechanisms remain poorly understood.
Messenger, Evan J., Royland, Joyce L., Greve, Hendrik J., Mumaw, Christen L., Block, Michelle L., Kodavanti, Prasada R. S., Kodavanti, Urmila P.   +6 more
core   +1 more source

Deferoxamine regulates neuroinflammation and iron homeostasis in a mouse model of postoperative cognitive dysfunction. [PDF]

, 2016
BACKGROUND: Postoperative cognitive dysfunction (POCD) is a common complication after surgery, especially amongst elderly patients. Neuroinflammation and iron homeostasis are key hallmarks of several neurological disorders. In this study, we investigated
Guocai Tao, Ke Pan, Jiao-lin Ning, Tao, Guocai, Lin Chen (54305), Yuping Li, Niccolò Terrando, Ting Yang, Li, Yuping, Lin Chen, Xiaojun Li, Chen, Lin, Jiao-lin Ning (3451655), Guocai Tao (3451661), Jianteng Gu (3451658), Jianteng Gu, Ning, Jiao-Lin, Pan, Ke, Xiaojun Li (138162), Terrando, Niccolò, Ke Pan (200562), Yuping Li (157863), Li, Xiaojun, Yang, Ting, Gu, Jianteng   +24 more
core   +1 more source

Microglial CD300f immune receptor contributes to the maintenance of neuron viability in vitro and after a penetrating brain injury

Scientific Reports, 2023
Emerging evidences suggest that immune receptors participate in diverse microglial and macrophage functions by regulating their immunometabolism, inflammatory phenotype and phagocytosis. CD300f, a TREM2-like lipid sensing immune receptor, that integrates
Daniela Alí-Ruiz, Nathalia Vitureira, Hugo Peluffo   +2 more
doaj   +1 more source

Structural and Functional Alterations in Visual Pathway After Optic Neuritis in MOG Antibody Disease: A Comparative Study With AQP4 Seropositive NMOSD

Frontiers in Neurology, 2021
Background: Optic neuritis (ON) is an important clinical manifestation of neuromyelitis optic spectrum disease (NMOSD). Myelin oligodendrocyte glycoprotein (MOG) antibody-related and aquaporin 4 (AQP4) antibody-related ON show different disease patterns.
Chenyang Gao, Zhizheng Zhuo, Yunyun Duan, Yajun Yao, Lei Su, Xinghu Zhang, Tian Song   +6 more
doaj   +1 more source

Human Brain Microvascular Endothelial Cells and Umbilical Vein Endothelial Cells Differentially Facilitate Leukocyte Recruitment and Utilize Chemokines for T Cell Migration

Clinical and Developmental Immunology, 2008
Endothelial cells that functionally express blood brain barrier (BBB) properties are useful surrogates for studying leukocyte-endothelial cell interactions at the BBB.
Shumei Man, Eroboghene E. Ubogu, Katherine A. Williams, Barbara Tucky, Melissa K. Callahan, Richard M. Ransohoff   +5 more
doaj   +1 more source

Experimental autoimmune encephalomyelitis from a tissue energy perspective [version 1; referees: 2 approved]

F1000Research, 2017
Increasing evidence suggests a key role for tissue energy failure in the pathophysiology of multiple sclerosis (MS). Studies in experimental autoimmune encephalomyelitis (EAE), a commonly used model of MS, have been instrumental in illuminating the ...
Roshni A Desai, Kenneth J Smith
doaj   +1 more source

Cellulose ether treatment inhibits amyloid beta aggregation, neuroinflammation and cognitive deficits in transgenic mouse model of Alzheimer’s disease

, 2023
Alzheimer’s disease (AD) is an incurable, progressive and devastating neurodegenerative disease. Pathogenesis of AD is associated with the aggregation and accumulation of amyloid beta (Aβ), a major neurotoxic mediator that triggers neuroinflammation and ...
Ali, Tahir,, Hallbeck, Martin,, Antonia N. Klein, Hermann M. Schatzl, Mukherjee, Priyanka Ganguli, Klein, Antonia N., Doh-ura, Katsumi, Tahir Ali, Klein, Antonia N.,, McDonald, Keegan, Keegan McDonald, Lovisa Johansson, Doh-ura, Katsumi,, Sabine Gilch, Schatzl, Hermann M.,, Schatzl, Hermann M., Johansson, Lovisa,, Ali, Tahir, Gilch, Sabine, Priyanka Ganguli Mukherjee, Mukherjee, Priyanka Ganguli,, Martin Hallbeck, Katsumi Doh-ura, McDonald, Keegan,, Hallbeck, Martin, Johansson, Lovisa, Gilch, Sabine,, Mukherjee, Priyanka G.   +27 more
core   +1 more source

Neurosteroids as regulators of neuroinflammation [PDF]

, 2022
Neuroinflammation is a physiological protective response in the context of infection and injury. However, neuroinflammation, especially if chronic, may also drive neurodegeneration. Neurodegenerative diseases, such as multiple sclerosis (MS), Alzheimer's
Karali, Kanelina, Chavakis, Triantafyllos, Charalampopoulos, Ioannis, Yilmaz, Canelif, Gravanis, Achille, Fodelianaki, Georgia, Alexaki, Vasileia Ismini   +6 more
core   +1 more source

Forced treadmill exercise can induce stress and increase neuronal damage in a mouse model of global cerebral ischemia

Neurobiology of Stress, 2016
Physical exercise is known to be a beneficial factor by increasing the cellular stress tolerance. In ischemic stroke, physical exercise is suggested to both limit the brain injury and facilitate behavioral recovery.
Martina Svensson, Philip Rosvall, Antonio Boza-Serrano, Emelie Andersson, Jan Lexell, Tomas Deierborg   +5 more
doaj   +1 more source

Angiotensin-II drives changes in microglia–vascular interactions in rats with heart failure

Communications Biology
Activation of microglia, the resident immune cells of the central nervous system, leading to the subsequent release of pro-inflammatory cytokines, has been linked to cardiac remodeling, autonomic disbalance, and cognitive deficits in heart failure (HF ...
Ferdinand Althammer, Ranjan K. Roy, Matthew K. Kirchner, Yuval Podpecan, Jemima Helen, Shaina McGrath, Elba Campos Lira, Javier E. Stern   +7 more
doaj   +1 more source