Results 31 to 40 of about 159,456 (265)

Microglial CD300f immune receptor contributes to the maintenance of neuron viability in vitro and after a penetrating brain injury

Scientific Reports, 2023
Emerging evidences suggest that immune receptors participate in diverse microglial and macrophage functions by regulating their immunometabolism, inflammatory phenotype and phagocytosis. CD300f, a TREM2-like lipid sensing immune receptor, that integrates
Daniela Alí-Ruiz, Nathalia Vitureira, Hugo Peluffo   +2 more
doaj   +1 more source

Structural and Functional Alterations in Visual Pathway After Optic Neuritis in MOG Antibody Disease: A Comparative Study With AQP4 Seropositive NMOSD

Frontiers in Neurology, 2021
Background: Optic neuritis (ON) is an important clinical manifestation of neuromyelitis optic spectrum disease (NMOSD). Myelin oligodendrocyte glycoprotein (MOG) antibody-related and aquaporin 4 (AQP4) antibody-related ON show different disease patterns.
Chenyang Gao, Zhizheng Zhuo, Yunyun Duan, Yajun Yao, Lei Su, Xinghu Zhang, Tian Song   +6 more
doaj   +1 more source

Human Brain Microvascular Endothelial Cells and Umbilical Vein Endothelial Cells Differentially Facilitate Leukocyte Recruitment and Utilize Chemokines for T Cell Migration

Clinical and Developmental Immunology, 2008
Endothelial cells that functionally express blood brain barrier (BBB) properties are useful surrogates for studying leukocyte-endothelial cell interactions at the BBB.
Shumei Man, Eroboghene E. Ubogu, Katherine A. Williams, Barbara Tucky, Melissa K. Callahan, Richard M. Ransohoff   +5 more
doaj   +1 more source

Experimental autoimmune encephalomyelitis from a tissue energy perspective [version 1; referees: 2 approved]

F1000Research, 2017
Increasing evidence suggests a key role for tissue energy failure in the pathophysiology of multiple sclerosis (MS). Studies in experimental autoimmune encephalomyelitis (EAE), a commonly used model of MS, have been instrumental in illuminating the ...
Roshni A Desai, Kenneth J Smith
doaj   +1 more source

Molecular pathogenesis of neuroinflammation [PDF]

Journal of Neurology, Neurosurgery & Psychiatry, 2003
The past few years have seen significant progress towards understanding the mechanisms of immune surveillance and inflammation in the nervous system. In this review, the milestones of scientific discovery in this field are discussed, and the strengths and limitations of the different ways of examining the molecular pathogenesis of neuro-inflammation ...
M, Bradl, R, Hohlfeld
openaire   +2 more sources

NEUROINFLAMMATION [PDF]

International Journal of Neuroscience Research, 2021
Inflammation is a complex process, mediated by cellular and molecular mechanisms caused by a response to a tissue damage from an aggressive agent, whether if biological, chemical or physical origin. This process occurs, ultimately, with the purpose of promoting defense, repair and tissue regeneration.
openaire   +1 more source

Forced treadmill exercise can induce stress and increase neuronal damage in a mouse model of global cerebral ischemia

Neurobiology of Stress, 2016
Physical exercise is known to be a beneficial factor by increasing the cellular stress tolerance. In ischemic stroke, physical exercise is suggested to both limit the brain injury and facilitate behavioral recovery.
Martina Svensson, Philip Rosvall, Antonio Boza-Serrano, Emelie Andersson, Jan Lexell, Tomas Deierborg   +5 more
doaj   +1 more source

Fc-Galactosylation of Human Immunoglobulin Gamma Isotypes Improves C1q Binding and Enhances Complement-Dependent Cytotoxicity

Frontiers in Immunology, 2017
Binding of the complement component C1q to the CH2 domain of antigen-bound immunoglobulin gamma (IgG) activates the classical complement pathway and depends on its close proximity to Fc fragments of neighboring antibodies. IgG subclasses contain a highly
Benjamin Peschke, Christian W. Keller, Patrick Weber, Isaak Quast, Isaak Quast, Jan D. Lünemann, Jan D. Lünemann   +6 more
doaj   +1 more source

Angiotensin-II drives changes in microglia–vascular interactions in rats with heart failure

Communications Biology
Activation of microglia, the resident immune cells of the central nervous system, leading to the subsequent release of pro-inflammatory cytokines, has been linked to cardiac remodeling, autonomic disbalance, and cognitive deficits in heart failure (HF ...
Ferdinand Althammer, Ranjan K. Roy, Matthew K. Kirchner, Yuval Podpecan, Jemima Helen, Shaina McGrath, Elba Campos Lira, Javier E. Stern   +7 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source