Results 31 to 40 of about 128,160 (300)

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

There Is No Parkinson Disease [PDF]

Archives of Neurology, 2008
The term Parkinson disease defines a specific clinical condition characterized by a typical history and characteristic signs. This review examines the historical evolution of the concept of Parkinson disease and how the misunderstanding of Parkinson disease may be hindering clinical research trials. It is proposed that this syndrome be called Parkinson
openaire   +2 more sources

Associação entre os níveis séricos de neopterina e a doença de Parkinson [PDF]

, 2012
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências da Saúde. Programa de Pós-Graduação em Ciências MédicasJustificativa: Evidências apontam para o envolvimento do sistema imune e neuroinflamação na gênese e progressão da ...
Freitas, Fernando Cini
core  

Genetic factors affecting dopaminergic deterioration during the premotor stage of Parkinson disease [PDF]

, 2021
To estimate dopaminergic dysfunction in patients with Parkinson disease (PD) during the premotor stage and to investigate the effect of genetic factors on the trajectories.
김한결, 류철형
core   +1 more source

PARK(ing) time–How park deficiency affects the biological clock in a Drosophila model of Parkinson's disease

FEBS Letters, EarlyView.
Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara, Kinga Skoczek, Elzbieta Pyza, Milena Damulewicz   +3 more
wiley   +1 more source

Microglia depletion reduces neurodegeneration and remodels extracellular matrix in a mouse Parkinson’s disease model triggered by α-synuclein overexpression

npj Parkinson's Disease
Chronic neuroinflammation with sustained microglial activation occurs in Parkinson’s disease (PD), yet the mechanisms and exact contribution of these cells to the neurodegeneration remains poorly understood.
Zhen Zhang, Kun Niu, Taoying Huang, Jiali Guo, Gongbikai Xarbat, Xiaoli Gong, Yunke Gao, Feiyang Liu, Shan Cheng, Wenting Su, Fei Yang, Zhaoyuan Liu, Florent Ginhoux, Ting Zhang   +13 more
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Verbascoside promotes the regeneration of tyrosine hydroxylase-immunoreactive neurons in the substantia nigra

Neural Regeneration Research, 2016
Tyrosine hydroxylase is a key enzyme in dopamine biosynthesis. Change in tyrosine hydroxylase expression in the nigrostriatal system is closely related to the occurrence and development of Parkinson′s disease.
Jian-qing Liang, Li Wang, Jian-cheng He, Xian-dong Hua   +3 more
doaj   +1 more source

Utility of manual fractional anisotropy measurements in the management of patients with Parkinson disease: a feasibility study with a 1.5-T magnetic resonance imaging system

Acta Radiologica Open, 2021
Background Diffusion tensor imaging has emerged as a promising tool for quantitative analysis of neuronal damage in Parkinson disease, with potential value for diagnostic and prognostic evaluation.
Romulo V de Oliveira, João S Pereira
doaj   +1 more source

Qualidade de vida e deglutição em indivíduos com doença de Parkinson que realizam terapia vocal [PDF]

, 2015
TCC(graduação) - Universidade Federal de Santa Catarina. Centro de Ciências da Saúde. Fonoaudiologia.Introdução: A doença de Parkinson é uma doença neurodegenerativa, em que ocorre diminuição da dopamina na substância negra, ocasionando alterações ...
Souza, Cintya Meneghel de
core