Results 31 to 40 of about 262,938 (292)
Role of mitochondria in Parkinson disease [PDF]
, 1999 The cause of the selective degeneration of nigrostriatal neurons in Parkinson disease (PD) has remained largely unknown. Exceptions include rare missense mutations in the alpha-synuclein gene on chromosome 4, a potentially pathogenic mutation affecting ...
Graeber, M. B. +4 more
core +1 more source
Immunosuppressants and risk of Parkinson disease [PDF]
, 2018 We performed a population-based case-control study of United States Medicare beneficiaries age 60-90 in 2009 with prescription data (48,295 incident Parkinson disease cases and 52,324 controls) to examine the risk of Parkinson disease in relation to use ...
Camacho-Soto, Alejandra +5 more
core +2 more sources
Neuroprotection of rapamycin in lactacystin-induced neurodegeneration via autophagy enhancement
Neurobiology of Disease, 2008 The ubiquitin–proteasome system (UPS) and the autophagy-lysosomal pathway (ALP) are the two most important cellular mechanisms for protein degradation.
Tianhong Pan +5 more
doaj +1 more source
Intravitreal Anti-VEGF Drugs and Signals of Dementia and Parkinson-Like Events: Analysis of the VigiBase Database of Spontaneous Reports [PDF]
, 2020 Introduction: Since vascular endothelial growth factor (VEGF) regulates several aspects of the central nervous system, particularly in dopaminergic neurons, VEGF inhibitors may be linked to Parkinson-like events and dementia, or variants of these ...
Avery +30 more
core +4 more sources
Frontiers in Neurology, 2018 BackgroundAlthough bedrooms are identified as a major location for accidents among Parkinson’s disease (PD) patients, there are no studies that specifically evaluate the bedroom environments of PD patients.ObjectiveTo examine the physical bedroom ...
Roongroj Bhidayasiri +11 more
doaj +1 more source
Lrrk promotes tau neurotoxicity through dysregulation of actin and mitochondrial dynamics. [PDF]
PLoS Biology, 2018 Mutations in leucine-rich repeat kinase 2 (LRRK2) are the most common cause of familial Parkinson disease. Genetics and neuropathology link Parkinson disease with the microtubule-binding protein tau, but the mechanism of action of LRRK2 mutations and the
Farah H Bardai +5 more
doaj +1 more source
DJ-1 isoforms in whole blood as potential biomarkers of Parkinson disease [PDF]
, 2012 DJ-1 is a multifunctional protein that plays an important role in oxidative stress, cell death, and synucleinopathies, including Parkinson disease. Previous studies have demonstrated that total DJ-1 levels decrease in the cerebrospinal fluid, but do not ...
Cain, Kevin C +14 more
core +2 more sources
Exploring the Association Between Rosacea and Parkinson Disease:A Danish Nationwide Cohort Study [PDF]
, 2016 Importance: The pathogenesis of rosacea is unclear, but increased matrix metalloproteinase target tissue activity appears to play an important role. Parkinson disease and other neurodegenerative disorders also display increased matrix metalloproteinase ...
Egeberg, Alexander +3 more
core +1 more source
Parkinson's Disease, 2015 Balance dysfunction (BD) in Parkinson’s disease (PD) is a disabling symptom, difficult to treat and predisposing to falls. The dopaminergic drugs or deep brain stimulation does not always provide significant improvements of BD and rehabilitative ...
Davide Ferrazzoli +7 more
doaj +1 more source
How to spot ocular abnormalities in progressive supranuclear palsy? A practical review
Translational Neurodegeneration, 2019 Background For parkinsonian disorders, progressive supranuclear palsy (PSP) continues to be significant for differential diagnosis. PSP presents a range of ocular abnormalities that have been suggested as optional tools for its early detection, apart ...
Onanong Phokaewvarangkul +1 more
doaj +1 more source