Results 51 to 60 of about 4,992,798 (298)
, 2022 reservedLa malattia di Parkinson è un disordine neurodegenerativo caratterizzato da sintomi motori (i.e., la sindrome extrapiramidale) e sintomi non motori. Tra quest’ultimi, il deterioramento cognitivo rappresenta probabilmente uno dei più invalidanti,
GRASSI, LAURA LUDOVICA
core
In silico and in vitro exploration of a tyrosinase for biocatalytic production of catechols
FEBS Open Bio, EarlyView.Tyrosinase from Ralstonia pseudosolanacearum is a promising biocatalyst for producing valuable catechols from monophenol substrates. This tyrosinase is uniquely suited to this due to its high monophenolase : diphenolase ratio. We combined in silico docking and in vivo kinetic characterisation of this tyrosinase with 11 industrially relevant monophenols,
James Britton +6 more
wiley +1 more source
O papel da dopamina no desenvolvimento de fadiga em modelo experimental de doença de Parkinson [PDF]
, 2013 Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Desportos, Programa de Pós-Graduação em Educação Física, Florianópolis, 2013A doença de Parkinson (DP) é a segunda doença neurodegenerativa mais prevalente na população, com maior
Scheffer, Débora da Luz
core
The role of the brain renin-angiotensin system in Parkinson´s disease
Translational NeurodegenerationThe renin-angiotensin system (RAS) was classically considered a circulating hormonal system that regulates blood pressure. However, different tissues and organs, including the brain, have a local paracrine RAS.
Jose Luis Labandeira-Garcia +3 more
doaj +1 more source
Acta Radiologica Open, 2021 Background Diffusion tensor imaging has emerged as a promising tool for quantitative analysis of neuronal damage in Parkinson disease, with potential value for diagnostic and prognostic evaluation.
Romulo V de Oliveira, João S Pereira
doaj +1 more source
Prejuízo no processamento olfatório emocional em um modelo animal de doença de Parkinson e o ambiente de criação como estratégia protetora [PDF]
, 2012 Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas, Programa de Pós-Graduação em Farmacologia, Florianópolis, 2011Os sintomas pré-motores da doença de Parkinson (DP) englobam diversas alterações emocionais ...
França, Sanmara de Lima
core
Gastrointestinal Biopsies for the Diagnosis of Alpha-Synuclein Pathology in Parkinson’s Disease
Gastroenterology Research and Practice, 2015 The diagnosis of Parkinson’s disease (PD) relies on clinical features whereas pathological confirmation is only possible with autopsy examination. The neuropathological hallmarks of PD are neuronal loss and the presence of inclusions termed Lewy bodies ...
Maria Graciela Cersosimo
doaj +1 more source
Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level
Aging and Cancer, EarlyView.This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley +1 more source
As alterações gastrointestinais e olfatórias precedem os sinais motores no modelo experimental da doença de Parkinson induzido pela rotenona [PDF]
, 2013 Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas. Programa de Pós-Graduação em Farmacologia, Florianópolis, 2013Existem hipóteses que o processo patológico da Doença de Parkinson inicia-se no Sistema Nervoso ...
Morais, Lívia Hecke
core
Primary skin fibroblasts as a model of Parkinson's disease [PDF]
, 2012 Parkinson's disease is the second most frequent neurodegenerative disorder. While most cases occur sporadic mutations in a growing number of genes including Parkin (PARK2) and PINK1 (PARK6) have been associated with the disease.
Morales-Gordo, B. +32 more
core +1 more source