Results 71 to 80 of about 5,373,856 (290)
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Neurochemical levels measured by brain MR spectroscopy (MRS) have been proposed as endpoints for clinical trials in early‐stage spinocerebellar ataxia (SCA) trials. We tested their trial‐readiness by quantifying neurochemicals in three affected brain regions in early‐stage cohorts of SCA2 and SCA3, examining their reproducibility in ...
James M. Joers +19 more
wiley +1 more source
Brain SciencesBackground/Objectives: Twins discordant for Parkinson’s disease (PD) share genetic background and early-life exposures, offering a model for non-genetic determinants of disease.
Michela Barichella +10 more
doaj +1 more source
Physical Activity in Early Parkinson Disease
, 2018 Physical activity and exercise improve outcomes in Parkinson disease (PD), however little is known about activity levels in early PD patients.We examined self-reported activity scores and examined associations with clinical characteristics in 383 PD ...
Duda, John E +7 more
core +1 more source
Parkinson Disease Epidemiology, Pathology, Genetics, and Pathophysiology [PDF]
, 2020 Parkinson disease is a complex, age-related, neurodegenerative disease associated with dopamine deficiency and both motor and nonmotor deficits. Many environmental and genetic factors influence Parkinson disease risk, with different factors predominating
Brundin, Patrik +2 more
core +1 more source
Characterizing Cutaneous α‐Synuclein Deposition and Seeding Activity in Parkinson's Disease Subtypes
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Cutaneous phosphorylated α‐synuclein (p‐syn) and α‐synuclein seeding activity are promising biomarkers for Parkinson's disease (PD), but their clinical value remains uncertain due to disease heterogeneity. This study evaluates these two biomarkers in PD patients to inform phenotype‐specific diagnosis and disease severity assessment ...
Yuting Jin +8 more
wiley +1 more source
Cells, 2019 Parkinson’s disease is associated with an increased risk of melanoma (and vice versa). Several hypotheses underline this link, such as pathways affecting both melanin and neuromelanin.
Dieter Leupold +9 more
doaj +1 more source
Long‐Term Neurologic Exam Findings in People Diagnosed and Treated During Acute HIV Infection
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Evaluate clinical and laboratory correlates of abnormal neurologic exam findings after acute HIV infection (AHI). Methods Participants from the RV254/SEARCH 010 cohort in Bangkok underwent standardized neurologic examinations at Weeks 0 (AHI), 12, 96, and 288 following antiretroviral therapy (ART).
Kathryn B. Holroyd +118 more
wiley +1 more source
A novel method for evaluating brain function and microstructural changes in Parkinson′s disease
Neural Regeneration Research, 2015 In this study, microstructural brain damage in Parkinson′s disease patients was examined using diffusion tensor imaging and tract-based spatial statistics.
Ming-fang Jiang +4 more
doaj +1 more source
Deep Learning Pose Estimation for Phenotyping of Co‐Occurring Hyperkinetic Movement Disorders
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective To explore whether routine outpatient video combined with deep learning‐based pose estimation and clinically interpretable kinematic features can support multi‐label phenotyping of co‐occurring hyperkinetic movement disorders (HMDs).
Laura Cif +17 more
wiley +1 more source
DIAGNOSIS OF THE PARKINSON DISEASE BY USING DEEP NEURAL NETWORK CLASSIFIER
Electrica, 2017 Parkinson disease occurs when certain clustersof brain cells are unable to generate dopamine which is needed to regulate thenumber of the motor and non-motor activity of the human body.
Abdullah CALISKAN +3 more
doaj +2 more sources