Results 91 to 100 of about 128,160 (300)

CSF Monoamine Metabolites and Cognitive Trajectory in Early Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Imaging and postmortem studies indicate that abnormalities in monoaminergic neurotransmission contribute to cognitive impairment in Parkinson's disease (PD). However, it remains uncertain if cerebrospinal fluid (CSF) monoamine metabolites can serve as biomarkers of cognitive decline in early PD.
Jing‐Yu Shao, Rong Li, Yu‐Xiang Jiao, Kai Ma, Hong‐Qi Yang, Zheng‐Yu Sun, Jie‐Wen Zhang, Shuai Chen   +7 more
wiley   +1 more source

ALDOA Promotes Glycolysis and NLRP3/GSDMD Pyroptosis to Accelerate ALS Progression

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is characterized by progressive motor neuron degeneration. Glycolytic dysregulation is implicated in disease progression, yet the underlying mechanisms remain unclear. This study investigates how Aldolase A (ALDOA) drives ALS progression through glycolysis‐mediated motor neuron pyroptosis.
Kaixin Yan, Yan Jiang, Yuxuan Yong, Tianshuo Zhang, Niannian Zhang, Qianqian Zeng, Xue Gong, Li Meng, Fangfang Bi, Yongmin Liu   +9 more
wiley   +1 more source

Long duration exercise program in individuals with parkinson´s disease: effects on functional capacity

, 2014
The aim of this study was to investigate the effects of long duration exercise program on physical fitness components of functional capacity in individuals with Parkinson disease (PD) and to evaluate ongoing effects of exercise after 8 to 10-week follow ...
Stella, Florindo, Baptista, André Macari, Arroyo, Claudia Teixeira, Lirani-Silva, Ellen, Beretta, Victor Spiandor, Vitório, Rodrigo, Barbieri, Fabio Augusto   +6 more
core   +1 more source

Modern Pharmacotherapy of Parkinson´s disease

, 2014
This thesis makes an effort to cover the most commonly used agents in the treatment of Parkinson´s disease as well as tracing out modern pharmacological therapeutic methods used in this disease.általános orvosangolegységes ...
Bhatti, Mohammad Arslan
core  

A lesão dopaminérgica como modelo de estágio pré-motor da doença de Parkinson: efeitos do antagonismo do receptor CB1 [PDF]

, 2012
Tese (doutorado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas, Programa de Pós-Graduação em Farmacologia, Florianópolis, 2010Além dos sinais motores clássicos, a doença de Parkinson é caracterizada por déficits cognitivos e ...
Tadaiesky, Meigy Tavares
core  

Age Cutoff for Early‐Onset Parkinson\u27s Disease:Recommendations from the International Parkinson and Movement Disorder Society Task Force on Early Onset Parkinson\u27s Disease

, 2022
BACKGROUND: Early-onset Parkinson\u27s disease (EOPD)/young-onset Parkinson\u27s disease (YOPD) is defined as Parkinson\u27s disease (PD) with an age at onset (AAO) after age 21 years but before the usual AAO for PD.
McConvey, Victor, Savica, Rodolfo, Smilowska, Katarzyna, Post, Bart, Tan, Eng-King, Zhang, Baorong, Mehanna, Raja, Hatano, Taku, International Parkinson and Movement Disorder Society Task Force on Early Onset Parkinson\u27s Disease, Pimentel Piemonte, Maria Elisa, Kumar, Kishore Raj, Fleisher, Jori   +11 more
core   +1 more source

Relationship Between Neurologic Symptoms and Signs and FMR1 Genotype in Premutation Carriers

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background and Objectives Fragile X‐associated Tremor/Ataxia Syndrome (FXTAS) is the most severe late‐onset condition caused by a premutation in the FMR1 gene, characterized by expanded CGG triplet repeats of 55–200. Clinical presentations of FXTAS, including gait ataxia, kinetic tremor, cognitive decline, and rare Parkinsonism, are linked to ...
Flora Tassone, Freddy Chafota, Miguel E. Rentería, Randi J. Hagerman, Ellery Santos, Anna Atkinson, Nicholas G. Martin, Elsdon Storey, Danuta Z. Loesch   +8 more
wiley   +1 more source

Parkinson′s disease

Annals of Indian Academy of Neurology, 2011
Behari, Madhuri, Bhattacharyya, Kalyan Brata, Borgohain, Rupam, Das, Shyamal Kumar, Ghosh, Bhaskar, Kishore, Asha, Krishnan, Syam, Mridula, K Rukmini, Muthane, Uday, Pal, Pramod Kumar, Sankhla, Charulata, Shukla, Garima   +11 more
  +8 more sources

Metabolic Parkinson’s disease

Frontiers in Aging Neuroscience
Parkinson’s disease (PD) is a neurodegenerative disorder primarily characterized by the loss of dopaminergic neurons in the substantia nigra. While most cases are sporadic, there is growing evidence of a link between PD and metabolic dysfunctions such as
Federica Invernizzi, Lorenzo Ciocca, Lorenzo Ciocca, Elena Contaldi, Donato Inverso, Donato Inverso, Daniela Calandrella, Daniela Calandrella, Francesco Mignone, Michela Barichella, Ioannis Ugo Isaias, Ioannis Ugo Isaias, Gianni Pezzoli, Gianni Pezzoli   +13 more
doaj   +1 more source

Effectiveness of rTMS on Working Memory and Inhibitory Impairments in Patients With Post‐Stroke Executive Deficits

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Considerable efforts have been dedicated to developing effective treatments for post‐stroke executive impairment (PSEI), among which repetitive transcranial magnetic stimulation (rTMS) has shown great potential. This study aimed to investigate the therapeutic effects of high‐frequency rTMS on working memory (WM) and response ...
Mengting Lao, Rongwei Du, Zhujun Wang, Yang Gao, Meiling Cheng, Xianglong Wang, Wen Wu   +6 more
wiley   +1 more source