Results 81 to 90 of about 128,160 (300)

Validity of a Wearable Digital Insole for Assessing Gait ON and OFF in Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Gait impairment is a distinctive symptom of Parkinson's disease that negatively impact mobility. We assessed the validity of wearable digital insoles against a validated reference gait analysis system for measuring select gait characteristics in patients with Parkinson's disease. Methods A comparative analysis between digital insoles
Deborah A. Hall, Kimberly Kwei, Rolando J. Acosta, Bharatkumar Koyani, Erin Robertson, Pratyush Rai, Roland Barge, Emily Timm, Nicollette L. Purcell, Natasha Desai, Dhanesh Patel, Ana‐Maria Visoiu‐Knapp, Samuel Stuart, Rinol Alaj, Matthew F. Wipperman, Oren Levy, Joan A. O'Keefe   +16 more
wiley   +1 more source

DIAGNOSIS OF THE PARKINSON DISEASE BY USING DEEP NEURAL NETWORK CLASSIFIER

Electrica, 2017
Parkinson disease occurs when certain clustersof brain cells are unable to generate dopamine which is needed to regulate thenumber of the motor and non-motor activity of the human body.
Abdullah CALISKAN, Hasan BADEM, Alper BAŞTÜRK, Mehmet Emin YÜKSEL   +3 more
doaj   +2 more sources

Baseline Regional Cholinergic Denervation Predicts Cognitive Trajectories in Moderate Parkinson Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Cognitive decline is a disabling and variable feature of Parkinson disease (PD). While cholinergic system degeneration is linked to cognitive impairments in PD, most prior research reported cross‐sectional associations. We aimed to fill this gap by investigating whether baseline regional cerebral vesicular acetylcholine transporter ...
Taylor Brown, Giulia Carli, Prabesh Kanel, Stiven Roytman, Jaimie Barr, Nicolaas I. Bohnen, Roger L. Albin   +6 more
wiley   +1 more source

Recruitment of patients with de novo Parkinson disease: successful strategies in a randomized exercise clinical trial

Trials, 2018
Introduction Recruitment of sufficient patients with Parkinson disease into clinical trials is a barrier to successful, timely study completion. Non-pharmacologic studies have shown to be even more challenging for recruitment, despite some studies ...
Deborah A. Hall, Charity Moore, Cynthia Comella, the SPARX Study Group   +3 more
doaj   +1 more source

Physical Activity in Early Parkinson Disease

, 2018
Physical activity and exercise improve outcomes in Parkinson disease (PD), however little is known about activity levels in early PD patients.We examined self-reported activity scores and examined associations with clinical characteristics in 383 PD ...
Duda, John E, Sneha Mantri, Fullard, Michelle E, Mantri, Sneha, Michelle E. Fullard, Morley, James F, John E. Duda, James F. Morley   +7 more
core   +1 more source

Motor assessment in Parkinson`s disease [PDF]

, 2017
Parkinson’s disease (PD) is one of most disabling disorders of the central nervous system. The motor symptoms of Parkinson’s disease: shaking, rigidity, slowness of movement, postural instability and difficulty with walking and gait, are difficult to ...
Andrzej Małecki, Józef Opara, Małecki, Andrzej, Elżbieta Małecka, Socha, Teresa, Opara, Józef A., Teresa Socha, Małecka, Elżbieta   +7 more
core   +1 more source

Clinical Validation of Plasma p‐217tau in Neurological Diseases

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Plasma p‐217tau is a minimally invasive but specific biomarker for diagnosing Alzheimer's disease (AD). However, its disease specificity remains to be clinically evaluated. We validated the reliability of the p‐217tau biomarker in 12 other neurological diseases.
Takeshi Kawarabayashi, Takumi Nakamura, Ryoma Takahashi, Tetsuya Ueda, Seiji Kinoshita, Chikage Uchida, Takashi Sugawara, Kentaro Hashimoto, Kunihiko Ishizawa, Masakuni Amari, Hiroo Kasahara, Yoshio Ikeda, Masamitsu Takatama, Mikio Shoji   +13 more
wiley   +1 more source

The Identification of Alpha-Synuclein as the First Parkinson Disease Gene

Journal of Parkinson’s Disease, 2017
In this Commentary, I describe the events that led from an NINDS-sponsored Workshop on Parkinson Disease Research in 1995, where I was asked to speak about the genetics of Parkinson disease, to the identification a mere two years later of a mutation in ...
Robert L. Nussbaum
doaj   +1 more source

Fatigue, mood disorders and sleep problems in patients with Parkinson's disease [PDF]

, 2008
De Ziekte van Parkinson (PD) is een langzaam progressieve ziekte gekarakteriseerd door zijn motorische en meer recentelijk herkende nietmotorische verschijnselen. Dit proefschrift richt zich op vermoeidheid, slaap problemen en stemmingsstoornissen, op de
Havlikova, Eva, Havlikova, Eva,
core  

Pros and cons of a prion-like pathogenesis in Parkinson's disease [PDF]

, 2011
Background: Parkinson's disease (PD) is a slowly progressive neurodegenerative disorder which affects widespread areas of the brainstem, basal ganglia and cerebral cortex.
Chapman Joab, Hilker, Ruediger, Brotchie, Jonathan M, Hilker, Rüdiger, Hilker Ruediger, Brotchie, Jonathan M., Joab Chapman, Ruediger Hilker, Chapman, Joab, Jonathan M Brotchie, Brotchie Jonathan M   +10 more
core   +1 more source