Results 81 to 90 of about 5,373,856 (290)

Founding Editorial: Neuro‐Drug Discovery

Neuro-Drug Discovery, EarlyView.
Wenbin Li
wiley   +1 more source

Natural Frequencies of Levodopa‐Induced Dyskinesia in Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives Abnormal involuntary movements, known as dyskinesias, are common complications of levodopa treatment in patients with Parkinson's disease and can significantly impair quality of life. The underlying pathophysiology remains unclear, and current therapeutic options are limited.
Ioannis U. Isaias, Federica Avantaggiato, Gianni Pezzoli, Andrea Canessa   +3 more
wiley   +1 more source

Global Rather Than Vertical‐Selective Saccadic Abnormalities in Progressive Supranuclear Palsy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To test whether vertical saccades are preferentially affected in Progressive Supranuclear Palsy (PSP). Methods PSP patients (n = 24) were compared to age‐matched controls (n = 94) and two degenerative groups (Alzheimer's disease, n = 20; Lewy body disease, n = 50).
Duy Duan Nguyen, Mark Paine, Soohyun Lee, Amir Fazlollahi, Baibin (Ben) Wang, John D. O'Sullivan, Peter J. Nestor   +6 more
wiley   +1 more source

Aspekty diagnozy i terapii zaburzeń połykania w schorzeniach pozapiramidowych na przykładzie choroby Parkinsona

Logopedia Silesiana, 2014
Aspects the diagnosis and the therapy of swallowing in extrapyramidal illnesses on the example of Parkinson disease In the article aspects of diagnosis and therapy of swallowing disorders in extrapyramidal illnesses on the example of Parkinson disease ...
Tatiana Lewicka
doaj  

The Identification of Alpha-Synuclein as the First Parkinson Disease Gene

Journal of Parkinson’s Disease, 2017
In this Commentary, I describe the events that led from an NINDS-sponsored Workshop on Parkinson Disease Research in 1995, where I was asked to speak about the genetics of Parkinson disease, to the identification a mere two years later of a mutation in ...
Robert L. Nussbaum
doaj   +1 more source

Recruitment of patients with de novo Parkinson disease: successful strategies in a randomized exercise clinical trial

Trials, 2018
Introduction Recruitment of sufficient patients with Parkinson disease into clinical trials is a barrier to successful, timely study completion. Non-pharmacologic studies have shown to be even more challenging for recruitment, despite some studies ...
Deborah A. Hall, Charity Moore, Cynthia Comella, the SPARX Study Group   +3 more
doaj   +1 more source

Polygenic risk of Parkinson disease is correlated with disease age at onset [PDF]

, 2015
We have investigated the polygenic architecture of Parkinson disease (PD) and have also explored the potential relationship between an individual's polygenic risk score and their disease age at ...
International, Parkinson's Disease Genomics Consortium, Heutink, P, Lubbe, S, Gasser, T, Nalls, MA, Williams, NM, Morris, HR, Brice, A, Wood, NW, IPDGC, consortium members, Escott-Price, V, Hardy, J, Singleton, AB, Williams, Nigel M., Heutink, Peter, Lubbe, Steven, Hardy, John, Singleton, Andrew B., International Parkinson's Disease Genomics Consortium, Wood, Nicholas W., Morris, Huw R., Nalls, Mike A., Brice, Alexis, Escott-Price, Valentina, Gasser, Thomas   +24 more
core   +1 more source

Diabetes‐Associated Cognitive Impairment: Pathophysiology and Emerging Therapies

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Diabetes‐associated cognitive impairment (DACI) is a common yet underrecognized condition, manifesting along a spectrum from mild cognitive impairment to dementia. DACI encompasses patients who develop vascular dementia (VaD) or Alzheimer's disease (AD) with diabetes as a risk factor; however, in certain patients, particularly those lacking ...
Osman Corbali, Priyanka Menon, Halil I. Corbali, Ram Jagannathan, Allan I. Levey   +4 more
wiley   +1 more source

Depression in Parkinson's disease: clinical-epidemiological correlates and comparison with a controlled group of non-parkinsonian geriatric patients Depressão na doença de Parkinson: análise clínico-epidemiológica e comparação com um grupo de pacientes geriátricos não parkinsonianos

Brazilian Journal of Psychiatry, 2009
OBJECTIVE: To evaluate and compare the frequency and severity of major depression in patients with Parkinson's disease and in individuals older than 60 years without neurological, rheumatological and/or oncological comorbidities.
Beatriz Azevedo dos Anjos Godke Veiga, Vanderci Borges, Sonia Maria César de Azevedo Silva, Fabrício de Oliveira Goulart, Maysa Seabra Cendoroglo, Henrique Ballalai Ferraz   +5 more
doaj   +1 more source

Twice-Daily versus Once-Daily Pramipexole Extended Release Dosage Regimens in Parkinson's Disease

, 2018
This open-label study aimed to compare once-daily and twice-daily pramipexole extended release (PER) treatment in Parkinson's disease (PD). PD patients on dopamine agonist therapy, but with unsatisfactory control, were enrolled.
윤지영
core   +1 more source