Results 111 to 120 of about 128,160 (300)

Striatal dual cholinergic /GABAergic transmission in Parkinson disease: friends or foes? [PDF]

, 2018
The rule of one terminal and one transmitter acting on one synapse clearly fails to cover the complexity of chemical synapse operation in the brain. Compelling evidence now indicates that two transmitters can be released from the same terminal, acting in
Constance Hammond, Natalia Lozovaya, Yehezkel Ben-Ari   +2 more
core   +1 more source

CAR T‐Cell Therapy in Neurology: A Scoping Review of Neuro‐Oncology, Autoimmune Diseases & Neurotoxicity

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Chimeric antigen receptor (CAR) T‐cell therapy has been investigated in neurological diseases, encompassing both central nervous system malignancies and autoimmune disorders, thereby extending its application beyond hematological cancers.
Omar Alqaisi, Mohammed Dibas, Patricia Tai, Ala Dibas, Osama Souied, Suhair Al‐Ghabeesh   +5 more
wiley   +1 more source

Recurrent Hypothermia and Autonomic Dysfunction Secondary to Shapiro Syndrome

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT A 44‐year‐old man presented with recurrent hypothermia, diaphoresis and hypertension. Extensive investigation for infectious, inflammatory, metabolic and endocrine aetiologies was negative. MR scan of the brain demonstrated no lesions but revealed callosal dysgenesis, consistent with Shapiro syndrome.
Naveen Kumar, Jeremy Johnson, Susanne Watkins, Eoin Mulroy   +3 more
wiley   +1 more source

Parkin deficiency delays motor decline and disease manifestation in a mouse model of synucleinopathy. [PDF]

, 2009
In synucleinopathies, including Parkinson's disease, partially ubiquitylated alpha-synuclein species phosphorylated on serine 129 (P(S129)-alpha-synuclein) accumulate abnormally.
Goujet-Zalc Cécile, Paleologou Katerina, Vitte Jérémie, Duchateau, René, Corti, Olga, Hamon Michel, Perez-Diaz, Fernando, Fournier Margot, Fernando Perez-Diaz, Saurini, Françoise, Traver, Sabine, Katerina Paleologou, Joubert, Chantal, Hilal A Lashuel, Christian Haass, Philipp J Kahle, Jean-Philippe Dullin, Charles Duyckaerts, Joubert Chantal, Garrigue Jérôme, Ardila-Osorio Héctor, Langui, Dominique, Michel Hamon, Jérémie Vitte, Margot Fournier, Cornilleau Fabien, Paleologou, Katerina, Duyckaerts Charles, Hanoun Naïma, Françoise Saurini, Corti Olga, Cécile Goujet-Zalc, Kahle Philipp J., Fabien Cornilleau, Haass Christian, Alexis Brice, Naïma Hanoun, Kahle, Philipp J., Cohen-Salmon, Charles, Dullin, Jean-Philippe, Fournier, Margot, Olga Corti, Hamon, Michel, Chantal Joubert, Vitte, Jérémie, René Duchateau, Cohen-Salmon Charles, Dominique Langui, Héctor Ardila-Osorio, Kahle, Philipp J, Traver Sabine, Cornilleau, Fabien, Lashuel Hilal A., Duchateau René, Jérôme Garrigue, Ardila-Osorio, Héctor, Langui Dominique, Garrigue, Jérôme, Haass, Christian, Lashuel, Hilal A., Brice Alexis, Duyckaerts, Charles, Brice, Alexis, Charles Cohen-Salmon, Perez-Diaz Fernando, Sabine Traver, Lashuel, Hilal A, Saurini Françoise, Goujet-Zalc, Cécile, Dullin Jean-Philippe, Hanoun, Naïma   +70 more
core   +1 more source

Sex‐Stratified Association of Regional Dopamine Transporter Binding With Disease Progression in Amyotrophic Lateral Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To clarify the clinical relevance of dopamine transporter single‐photon emission computed tomography (DAT‐SPECT) abnormalities in amyotrophic lateral sclerosis (ALS), with a prespecified focus on sex‐stratified associations with disease progression and short‐term prognosis.
Tomoya Kawazoe, Keizo Sugaya, Kentaro Hayashi, Keiko Hino, Yasuhiro Nakata, Kota Bokuda, Toshio Shimizu, Kazushi Takahashi   +7 more
wiley   +1 more source

Estratégias ambientais como alternativas para a prevenção de sintomas de ansiedade e depressão em um modelo experimental da doença de Parkinson em ratos [PDF]

, 2012
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas, Programa de Pós-Graduação em Neurociências, Florianópolis, 2011A doença de Parkinson (DP) é uma doença multifatorial que se caracteriza pela degeneração ...
Savoldi, Robson
core  

Dietary Caffeine and Brain Dopaminergic Function in Parkinson Disease [PDF]

Objective: This study was undertaken to investigate the effects of dietary caffeine intake on striatal dopamine function and clinical symptoms in Parkinson disease in a cross-sectional and longitudinal setting.
Jaakkola, Elina, Myller, Elina, Scheperjans, Filip, Kuusimäki, Tomi, Honkanen, Emma A., Chaudhuri, Kallol Ray, Nuuttila, Simo, Antonini, Angelo, Kaasinen, Valtteri, Mertsalmi, Tuomas, Joutsa, Juho, Lehtonen, Marko, Seppänen, Marko, Saarinen, Emmi K, Murtomäki, Kirsi, Niemi, Kalle, Eklund, Mikael, Levo, Reeta, Noponen, Tommi, Honkanen, Emma A, Lindholm, Kari, Ihalainen, Toni, Vahlberg, Tero, Saarinen, Emmi K.   +23 more
core   +1 more source

A Two‐Stage Questionnaire and Actigraphy Screening for iRBD in a Multicenter Retrospective Cohort

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Isolated rapid‐eye‐movement sleep behavior disorder is a prodromal marker of synucleinopathies. However, most cases remain undiagnosed due to the insufficient predictive value of questionnaires and limited access to confirmatory video‐polysomnography. We assessed a two‐stage screening strategy combining a brief questionnaire on rapid‐
Caleb A. Massimi, Giorgio Ricciardiello Mejia, Andre Metzger, Kang Hyun Ryu, Salonee Marwaha, Eva Grzegorczyk, Li Zhou, Eliana Jacobs, Boris Gilyadov, Claudia Kunney, Liqhwa Ncube, Ankit Parekh, Emmanuel Mignot, Fanny M. Elahi, Joseph Winer, Kathleen Poston, Andreas Brink‐Kjaer, Emmanuel H. During   +17 more
wiley   +1 more source

The effectiveness of traditional methods and altered auditory feedback in improving speech rate and intelligibility in speakers with Parkinson's disease

, 2010
Communication problems are a frequent symptom for people with Parkinson's disease (PD) which can have a significant impact on their quality-of-life. Deciding on the right management approach can be problematic though, as, with the exception of LSVT (R ...
Kröger, Bernd J., Bernd Kröger, Lowit, Anja, Anja Lowit, Howell, Peter, Corinne Dobinson, Claire Timmins, Dobinson, Corinne, Peter Howell, Timmins, Claire, Kröger, Bernd   +10 more
core   +1 more source

Neurochemical Endpoints to Inform Early‐Stage Trials of Spinocerebellar Ataxia 2 and 3 in a Multisite Setting

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Neurochemical levels measured by brain MR spectroscopy (MRS) have been proposed as endpoints for clinical trials in early‐stage spinocerebellar ataxia (SCA) trials. We tested their trial‐readiness by quantifying neurochemicals in three affected brain regions in early‐stage cohorts of SCA2 and SCA3, examining their reproducibility in ...
James M. Joers, Yaqiao Wei, Dinesh K. Deelchand, Adam Berrington, Young Woo Park, Guita Banan, Michal Povazan, Jens T. Rosenberg, André J. W. van der Kouwe, Tetsuo Ashizawa, Khalaf O. Bushara, Chiadi U. Onyike, Sub H. Subramony, Jeremy D. Schmahmann, Brian J. Soher, Peter B. Barker, Thomas H. Mareci, Eva‐Maria Ratai, Lynn E. Eberly, Gülin Öz   +19 more
wiley   +1 more source