Results 11 to 20 of about 128,160 (300)
Transcriptome analysis in LRRK2 and idiopathic Parkinson’s disease at different glucose levels
npj Parkinson's Disease, 2021 Type-2 diabetes (T2D) and glucose metabolic imbalances have been linked to neurodegenerative diseases, including Parkinson’s disease (PD). To detect potential effects of different glucose levels on gene expression, by RNA-seq we analyzed the ...
Rubén Fernández-Santiago +9 more
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Frontiers in Immunology, 2023 Epigenetic reprogramming is the ability of innate immune cells to form memories of environmental stimuli (priming), allowing for heightened responses to secondary stressors.
Minhong Huang +11 more
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The Lancet, 2021 Parkinson's disease is a recognisable clinical syndrome with a range of causes and clinical presentations. Parkinson's disease represents a fast-growing neurodegenerative condition; the rising prevalence worldwide resembles the many characteristics typically observed during a pandemic, except for an infectious cause.
Bloem, B.R., Okun, M.S., Klein, C.
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Microbiota Dysbiosis in Parkinson Disease—In Search of a Biomarker
Biomedicines, 2022 Numerous studies have highlighted the role of the gastrointestinal system in Parkinson disease pathogenesis. It is likely triggered by proinflammatory markers produced by specific gut bacteria. This review’s aim is to identify gut bacterial biomarkers of
Julia Maya Nowak +4 more
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npj Parkinson's Disease, 2022 The assessment of cognitive deficits is pivotal for diagnosis and management in patients with parkinsonisms. Low levels of correspondence are observed between evaluations assessed with screening cognitive tests in comparison with those assessed with in ...
Paola Ortelli +15 more
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Human Molecular Genetics, 2007 Parkinson's disease (PD) is a chronic progressive neurodegenerative movement disorder characterized by a profound and selective loss of nigrostriatal dopaminergic neurons. Clinical manifestations of this complex disease include motor impairments involving resting tremor, bradykinesia, postural instability, gait difficulty and rigidity.
Bobby, Thomas, M Flint, Beal
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Neuroprotection of rapamycin in lactacystin-induced neurodegeneration via autophagy enhancement
Neurobiology of Disease, 2008 The ubiquitin–proteasome system (UPS) and the autophagy-lysosomal pathway (ALP) are the two most important cellular mechanisms for protein degradation.
Tianhong Pan +5 more
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Lrrk promotes tau neurotoxicity through dysregulation of actin and mitochondrial dynamics. [PDF]
PLoS Biology, 2018 Mutations in leucine-rich repeat kinase 2 (LRRK2) are the most common cause of familial Parkinson disease. Genetics and neuropathology link Parkinson disease with the microtubule-binding protein tau, but the mechanism of action of LRRK2 mutations and the
Farah H Bardai +5 more
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Frontiers in Neurology, 2018 BackgroundAlthough bedrooms are identified as a major location for accidents among Parkinson’s disease (PD) patients, there are no studies that specifically evaluate the bedroom environments of PD patients.ObjectiveTo examine the physical bedroom ...
Roongroj Bhidayasiri +11 more
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Parkinson's Disease, 2015 Balance dysfunction (BD) in Parkinson’s disease (PD) is a disabling symptom, difficult to treat and predisposing to falls. The dopaminergic drugs or deep brain stimulation does not always provide significant improvements of BD and rehabilitative ...
Davide Ferrazzoli +7 more
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