Results 11 to 20 of about 3,107,227 (309)

Data-Driven Sequence of Changes to Anatomical Brain Connectivity in Sporadic Alzheimer’s Disease

Frontiers in Neurology, 2017
Model-based investigations of transneuronal spreading mechanisms in neurodegenerative diseases relate the pattern of pathology severity to the brain’s connectivity matrix, which reveals information about how pathology propagates through the connectivity ...
Neil P. Oxtoby, Sara Garbarino, Nicholas C. Firth, Nicholas C. Firth, Jason D. Warren, Jonathan M. Schott, Daniel C. Alexander, For the Alzheimer’s Disease Neuroimaging Initiative   +7 more
doaj   +1 more source

Selective Fetal Growth Restriction in Dichorionic Twin Pregnancies: Diagnosis, Natural History, and Perinatal Outcome. [PDF]

, 2020
This study aims to evaluate the natural history, disease progression, and outcomes in dichorionic twins with selective fetal growth restriction (sFGR) according to different diagnostic criteria and time of onset.
Antonakopoulos, N, Kalafat, E, Khalil, A, Liu, B, Pateisky, P, Thilaganathan, B   +5 more
core   +2 more sources

Progressive Thoughts about Progressive Disease [PDF]

Clinical Cancer Research, 2007
In this issue of Clinical Cancer Research , Desai et al. ([1][1]) present evidence that new modules appearing in preexisting lesions can represent clonally resistant populations. Imatinib mesylate, the prototypic oral tyrosine kinase inhibitor that has activity against ABL, KIT, and platelet-
openaire   +2 more sources

Clinical and genetic characteristics of Korean autosomal dominant polycystic kidney disease patients [PDF]

The Korean Journal of Internal Medicine, 2021
Autosomal dominant polycystic kidney disease (ADPKD) is the most common hereditary kidney disease. It is characterized by cyst growth in the kidneys, resulting in kidney enlargement and end-stage kidney disease. The polycystic kidney disease 1 (PKD1) and
Yun Kyu Oh, Hayne Cho Park, Hyunjin Ryu, Yong-Chul Kim, Kook-Hwan Oh   +4 more
doaj   +1 more source

What Is the Efficacy of Sotrovimab in Reducing Disease Progression and Death in People with COVID-19 during the Omicron Era? Answers from a Real-Life Study

Viruses, 2023
(1) Introduction: Since May 2021, sotrovimab has been available in Italy for early treatment of SARS-CoV-2 infection and to prevent disease progression. However, some in vitro studies have questioned its efficacy on Omicron variants. Therefore, we aim to
Andrea De Vito, Agnese Colpani, Mariacristina Poliseno, Lucia Diella, Francesco Rosario Paolo Ieva, Alessandra Belati, Roberto Papale, Sergio Babudieri, Laura De Santis, Annalisa Saracino, Sergio Lo Caputo, Giordano Madeddu   +11 more
doaj   +1 more source

Rapid Breast Cancer Disease Progression Following Cyclin Dependent Kinase 4 and 6 Inhibitor Discontinuation. [PDF]

, 2017
Background: CDK 4 and 6 inhibitors (CDK4/6i), which arrest unregulated cancer cell proliferation, show clinical efficacy in breast cancer. Unexpectedly, a patient treated on a CDK4/6i-based trial, as first-line therapy in metastatic breast cancer ...
Abouharb, Sausan, Bashour, Sami I, Brown, Powel H, Doostan, Iman, Ibrahim, Nuhad K, Karuturi, Meghan, Keyomarsi, Khandan, Koenig, Kimberly B, Litton, Jennifer K, Moulder-Thompson, Stacy L, Tripathy, Debasish, Ueno, Naoto T, Valero, Vicente   +12 more
core   +2 more sources

Machine Learning Use for Prognostic Purposes in Multiple Sclerosis

Life, 2021
The course of multiple sclerosis begins with a relapsing-remitting phase, which evolves into a secondarily progressive form over an extremely variable period, depending on many factors, each with a subtle influence. To date, no prognostic factors or risk
Ruggiero Seccia, Silvia Romano, Marco Salvetti, Andrea Crisanti, Laura Palagi, Francesca Grassi   +5 more
doaj   +1 more source

The role of changes in extracellular matrix of cartilage in the presence of inflammation on the pathology of osteoarthritis. [PDF]

, 2013
Osteoarthritis (OA) is a degenerative disease that affects various tissues surrounding joints such as articular cartilage, subchondral bone, synovial membrane, and ligaments.
Maldonado, Maricela, Nam, Jin
core   +3 more sources

Utility of laboratory and immune biomarkers in predicting disease progression and mortality among patients with moderate to severe COVID-19 disease at a Philippine tertiary hospital

Frontiers in Immunology, 2023
PurposeThis study was performed to determine the clinical biomarkers and cytokines that may be associated with disease progression and in-hospital mortality in a cohort of hospitalized patients with RT-PCR confirmed moderate to severe COVID-19 infection ...
Felix Eduardo R. Punzalan, Felix Eduardo R. Punzalan, Jaime Alfonso M. Aherrera, Jaime Alfonso M. Aherrera, Sheriah Laine M. de Paz-Silava, Alric V. Mondragon, Alric V. Mondragon, Anna Flor G. Malundo, Anna Flor G. Malundo, Joanne Jennifer E. Tan, Joanne Jennifer E. Tan, Ourlad Alzeus G. Tantengco, Ourlad Alzeus G. Tantengco, Elgin Paul B. Quebral, Mary Nadine Alessandra R. Uy, Mary Nadine Alessandra R. Uy, Ryan C. V. Lintao, Jared Gabriel L. Dela Rosa, Maria Elizabeth P. Mercado, Krisha Camille Avenilla, Jonnel B. Poblete, Albert B. Albay, Albert B. Albay, Aileen S. David-Wang, Aileen S. David-Wang, Marissa M. Alejandria, Marissa M. Alejandria, Marissa M. Alejandria   +27 more
doaj   +1 more source

Invariant NKT cells contribute to chronic lymphocytic leukemia surveillance and prognosis [PDF]

, 2017
Chronic lymphocytic leukemia (CLL) is characterized by the expansion of malignant CD5(+) B lymphocytes in blood, bone marrow and lymphoid organs. CD1d-restricted invariant Natural Killer T (iNKT) cells are innate-like T lymphocytes strongly implicated in
Azzimonti, Laura, Bellone, Matteo, Bertilaccio, Maria Teresa, Caligaris Cappio, Federico, Capri, Miriam, Casorati, Giulia, de Lalla, Claudia, Delfanti, Gloria, Dellabona, Paolo, DI NAPOLI, Arianna, Doglioni, Claudio, Franceschi, Claudio, Ghia, Paolo, Gorini, Francesca, Gulino, Alessandro, Ranghetti, Pamela, Scarfò, Lydia, Scielzo, Cristina   +17 more
core   +1 more source