Results 1 to 10 of about 851,361 (268)

Distinct Responses to IL4 in Macrophages Mediated by JNK

Cells, 2023
IL(Interleukin)-4 is the main macrophage M2-type activator and induces an anti-inflammatory phenotype called alternative activation. The IL-4 signaling pathway involves the activation of STAT (Signal Transducer and Activator of Transcription)-6 and ...
Luís Arpa, Carlos Batlle, Peijin Jiang, Carme Caelles, Jorge Lloberas, Antonio Celada   +5 more
doaj   +1 more source

GM-CSF Protects Macrophages from DNA Damage by Inducing Differentiation

Cells, 2022
At inflammatory loci, pro-inflammatory activation of macrophages produces large amounts of reactive oxygen species (ROS) that induce DNA breaks and apoptosis. Given that M-CSF and GM-CSF induce two different pathways in macrophages, one for proliferation
Tania Vico, Catrin Youssif, Fathema Zare, Mònica Comalada, Carlos Sebastian, Jorge Lloberas, Antonio Celada   +6 more
doaj   +1 more source

NAD kinase promotes Staphylococcus aureus pathogenesis by supporting production of virulence factors and protective enzymes

eLife, 2022
Nicotinamide adenine dinucleotide phosphate (NADPH) is the primary electron donor for reductive reactions that are essential for the biosynthesis of major cell components in all organisms.
Clarisse Leseigneur, Laurent Boucontet, Magalie Duchateau, Javier Pizarro-Cerda, Mariette Matondo, Emma Colucci-Guyon, Olivier Dussurget   +6 more
doaj   +1 more source

Matrix Stiffening Enhances DNCB-Induced IL-6 Secretion in Keratinocytes Through Activation of ERK and PI3K/Akt Pathway

Frontiers in Immunology, 2021
Matrix stiffness, a critical physical property of the cellular environment, is implicated in epidermal homeostasis. In particular, matrix stiffening during the pathological progression of skin diseases appears to contribute to cellular responses of ...
Hyewon Chung, Seunghee Oh, Seunghee Oh, Hyun-Woo Shin, Hyun-Woo Shin, Yunam Lee, Hyungsuk Lee, Seung Hyeok Seok, Seung Hyeok Seok   +8 more
doaj   +1 more source

Exploring Zebrafish Larvae as a COVID-19 Model: Probable Abortive SARS-CoV-2 Replication in the Swim Bladder

Frontiers in Cellular and Infection Microbiology, 2022
Animal models are essential to understanding COVID-19 pathophysiology and for preclinical assessment of drugs and other therapeutic or prophylactic interventions.
Valerio Laghi, Veronica Rezelj, Laurent Boucontet, Maxence Frétaud, Bruno Da Costa, Pierre Boudinot, Irene Salinas, Georges Lutfalla, Marco Vignuzzi, Jean-Pierre Levraud, Jean-Pierre Levraud   +10 more
doaj   +1 more source

Photobiomodulation Effect of 850 nm Near-infrared Diode Laser on the Release of M1-related Cytokines Inmonocytic THP-1 Cells [PDF]

International Journal Bioautomation, 2023
Photobiomodulation (PBM) is a form of the use of visible red and Near-infrared (NIR) light at low power, where a laser light photon is absorbed at the electronic level, without heat production.
Ruwaidah A. Mussttaf, Mayyadah Hasan Rhaif Al-Sahlanee, Numan S. Dawood, David F. L. Jenkins, Awadhesh N. Jha   +4 more
doaj   +1 more source

Circumsporozoite Protein of Plasmodium berghei- and George Baker Virus A-Derived Peptides Trigger Efficient Cell Internalization of Bioconjugates and Functionalized Poly(ethylene glycol)-b-poly(benzyl malate)-Based Nanoparticles in Human Hepatoma Cells

Pharmaceutics, 2022
In order to identify the peptides, selected from the literature, that exhibit the strongest tropism towards human hepatoma cells, cell uptake assays were performed using biotinylated synthetic peptides bound to fluorescent streptavidin or engrafted onto ...
Elise Vène, Kathleen Jarnouen, Catherine Ribault, Manuel Vlach, Yann Verres, Mickaël Bourgeois, Nicolas Lepareur, Sandrine Cammas-Marion, Pascal Loyer   +8 more
doaj   +1 more source

Pulmonary macrophages [PDF]

European Respiratory Journal, 1994
Interest in pulmonary macrophage research has greatly increased as is now possible not only to work with the easily accessible alveolar macrophages but also with macrophages prepared from lung tissue, such as the interstitial macrophages, dendritic cells and intravascular macrophages.
M L, Lohmann-Matthes, C, Steinmüller, G, Franke-Ullmann   +2 more
openaire   +2 more sources

PTEN inhibits AMPK to control collective migration

Nature Communications, 2022
Pten is a tumour suppressor gene that is associated with highly invasive cancers such as glioblastoma. Here the authors show that PTEN loss results in increased migratory behaviour, which can be countered by targeting AMPK activity.
Florent Peglion, Lavinia Capuana, Isabelle Perfettini, Laurent Boucontet, Ben Braithwaite, Emma Colucci-Guyon, Emie Quissac, Karin Forsberg-Nilsson, Flora Llense, Sandrine Etienne-Manneville   +9 more
doaj   +1 more source

Nucleocapsid and Spike Proteins of the Coronavirus SARS-CoV-2 Induce IL6 in Monocytes and Macrophages—Potential Implications for Cytokine Storm Syndrome

Vaccines, 2021
The pandemic of the new coronavirus SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) has led to the deaths of more than 1.5 million people worldwide.
Iwona Karwaciak, Anna Sałkowska, Kaja Karaś, Jarosław Dastych, Marcin Ratajewski   +4 more
doaj   +1 more source