Results 31 to 40 of about 981,188 (268)

Statement of Retraction: Two novel coordination polymers: protective activity on acute lung injury via inhibiting the release of inflammatory cytokines in alveolar macrophages [PDF]

, 2023

openalex   +1 more source

Development of human monoclonal antibodies against TARM1 by yeast display

FEBS Open Bio, EarlyView.
Human monoclonal antibodies against TARM1 are generated by yeast display‐guided selection. These antibodies bind to soluble and cell‐surface forms of TARM1. Also, these antibodies exhibit agonistic activity in the NFAT‐GFP reporter assay, indicating that TARM1 signaling can be functionally modulated by antibodies and suggesting TARM1 as a potential ...
Rikio Yabe, Mayumi Saeki, Masaaki Hashiguchi, Sayaka Ono, Kazuhisa Aoki, Hidetaka Tanno   +5 more
wiley   +1 more source

MiR‐513a promotes human erythroid differentiation by modulating c‐Jun

FEBS Open Bio, EarlyView.
During early human erythropoiesis, miR‐513a promoted erythroid differentiation in primary human CD34+ hematopoietic stem‐progenitor cells and human TF‐1 erythroleukemic cells by indirectly decreasing c‐Jun and phospho‐c‐Jun expression, which are associated with increased GATA1 expression.
MinJung Kim, Brittany Taylor, Shannon Bolten, Christian L. Eberly, Mahliya Abdurahman, T. Michael Creed, Acong Yang, Taylor L. Hatchet, Tristan Dyson, Shuo Gu, Curt I. Civin, Tami J. Kingsbury   +11 more
wiley   +1 more source

Peer Review #3 of "MK8617 inhibits M1 macrophage polarization and inflammation via the HIF-1α/GYS1/UDPG/P2Y14 pathway (v0.1)"

, 2023
Lingling Qian, Xiaoqin Chen, Deyang Kong, Gaoyuan Wang, Yun Cao, Yingchun Xiao, Jing-Yuan Cao, Chunbo Zou, L Chen, H Deng, H Cui, J Fang, Z Zuo, J Deng, Y Li, X Wang, L Zhao, A Murao, M Aziz, H Wang, M Brenner, P Wang, E Ross, A Devitt, J Johnson, P Cole, R Scrivo, M Vasile, I Bartosiewicz, G Valesini, Y Liu, X Zou, Y Chai, Y Yao, Y Na, M Stakenborg, S Seok, G Matteoli, P Jaakkola, D Mole, Y Tian, M Wilson, J Gielbert, S Gaskell, Von Kriegsheim, A Hebestreit, H Mukherji, M Schofield, C Maxwell, P Pugh, C Ratcliffe, P, A Mcgettrick, O' Neill, Laj, N Gupta, J Wish, A Miao, J Liang, L Yao, J Han, L Zhou, F Han, G Wu, S Han, Z Li, Y Jia, L Bai, X Li, K Wang, F Yang, J Zhang, X Wang, H Guan, S Linlin, J Han, D Hu, Y Kim, E Yi, Y Kim, A Lee, J Chung, H Ha, J Cho, S Kim, H Ko, J Cheon, Y Hong, Chang Sy, M Ito, T Tanaka, T Ishii, T Wakashima, K Fukui, M Nangaku, M Adeva-Andany, M Gonzlez-Lucn, C Donapetry-Garca, C Fernndez-Fernndez, Ameneiros-Rodrguez   +99 more
openalex   +1 more source

Macrophages in xenotransplantation [PDF]

Korean Journal of Transplantation, 2019
Xenotransplantation refers to organ transplantation across species. Immune rejection of xenografts is stronger and faster than that of allografts because of significant molecular differences between species. Recent studies have revealed the involvement of macrophages in xenograft and allograft rejections.
openaire   +3 more sources

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

FEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani, Eiman Y. Ibrahim, Rozalyn L. Rodwin, Leah M. Ferrucci, Kim Blenman, Maryam Lustberg, Barbara E. Ehrlich   +6 more
wiley   +1 more source

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

ACVR1R206H extends inflammatory responses in human induced pluripotent stem cell-derived macrophages

, 2021
Koji Matsuo, Abigail Lepinski, Robert Dalton Chavez, Emilie Barruet, Ashley Pereira, Tania Moody, Amy N. Ton, Aditi Sharma, Judith Hellman, Kiichiro Tomoda, Mary C. Nakamura, Edward C. Hsiao   +11 more
openalex   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source