Results 1 to 10 of about 646,237 (202)

Macrophage Activation Syndrome [PDF]

Hematology/Oncology Clinics of North America, 2015
Macrophage activation syndrome (MAS) is a potentially life-threatening complication of rheumatic disorders that occurs most commonly in systemic juvenile idiopathic arthritis. In recent years, there have been several advances in the understanding of the pathophysiology of MAS. Furthermore, new classification criteria have been developed.
Angelo Ravelli, Sérgio Davi, Francesca Minoia   +2 more
exaly   +7 more sources

METTL3/RBM15 augments the stability of Kdm6b mRNA and promotes STAT1-mediated macrophage activation and atherosclerosis [PDF]

Experimental and Molecular Medicine
Atherosclerosis is the underlying cause of cardiovascular disease. Recent studies have shown that N 6-methyladenosine (m6A) modification in macrophages is associated with atherosclerosis progression.
Ning Huangfu, Fang Li, Chenqiu Wang, Shouyi Jin, Xiaoya Zheng, Yingsong Wang, Tianxiang Fang, Jiaxi Shen, Yanan Yu, Liguo Jian, Datun Qi, Wenting Zhao, Dongdong Jian   +12 more
doaj   +2 more sources

Neutralization of IFN-γ reverts clinical and laboratory features in a mouse model of macrophage activation syndrome [PDF]

Journal of Allergy and Clinical Immunology, 2018
BACKGROUND: The pathogenesis of macrophage activation syndrome (MAS) is not clearly understood: a large body of evidence supports the involvement of mechanisms similar to those implicated in the setting of primary hemophagocytic lymphohistiocytosis ...
Giusi Prencipe, Ivan Caiello, Antonia Pascarella   +2 more
exaly   +3 more sources

RANKL promotes airway inflammation via pro-inflammatory alveolar macrophage activation in COPD [PDF]

Respiratory Research
Background Chronic airway inflammation is a key mechanism involved in the pathogenesis and progression of chronic obstructive pulmonary disease (COPD).
Lu Zhou, Baiquan Zhang, Huanqin Wang, Jintao Liu, Lijun Miao   +4 more
doaj   +2 more sources

Chronic macrophage activation derails muscle repair by disrupting mannose-receptor-linked plasticity revealed by endogenous irg1/acod1 tracking [PDF]

Nature Communications
Macrophages are central drivers of chronic inflammation, yet how a sustained inflammatory state alters their function remains unclear. Using GFP knock-in zebrafish targeting irg1/acod1 that marks macrophage activation, we track the dynamic transitions of
Caroline G. Spencer, Matthew Hamilton, Ethan Bedsole, Yingshan N. Wei, Alison M. Rojas, Andrew Burciu, John Zhu, Keith Z. Sabin, Celia E. Shiau   +8 more
doaj   +2 more sources

Damage-Induced Calcium Signaling and Reactive Oxygen Species Mediate Macrophage Activation in Zebrafish

Frontiers in Immunology, 2021
Immediately after a wound, macrophages are activated and change their phenotypes in reaction to danger signals released from the damaged tissues. The cues that contribute to macrophage activation after wounding in vivo are still poorly understood ...
Tamara Sipka, Romain Peroceschi, Rahma Hassan-Abdi, Martin Groß, Felix Ellett, Felix Ellett, Christina Begon-Pescia, Catherine Gonzalez, Georges Lutfalla, Mai Nguyen-Chi   +9 more
doaj   +1 more source

Solanum nigrum induces macrophage activation through TLR4-mediated activation of JNK and macrophage autophagy through TLR4-mediated activation of p38 and JNK

Food and Agricultural Immunology, 2022
In this study, we investigated the effect of Solanum nigrum aerial parts (SNAP) on macrophage activation and macrophage autophagy in RAW264.7 cells. SNAP increased the production of immunostimulatory factors and phagocytosis in RAW264.7 cells.
Ju Hyung Yu, Min Yeong Choi, So Jung Park, Na Gyeong Geum, Jae Won Lee, Gwang Hun Park, Hyun Ji Eo, Jin Boo Jeong   +7 more
doaj   +1 more source

ARRB1 suppresses the activation of hepatic macrophages via modulating endoplasmic reticulum stress in lipopolysaccharide-induced acute liver injury

Cell Death Discovery, 2021
Acute liver injury (ALI) caused by multiple inflammatory responses is a monocyte-/macrophage-mediated liver injury that is associated with high morbidity and mortality. Liver macrophage activation is a vital event that triggers ALI.
Yiming Lei, Sizhe Wan, Huiling Liu, Haoxiong Zhou, Lingjun Chen, Yidong Yang, Bin Wu   +6 more
doaj   +1 more source

In Vitro Screening Method for Characterization of Macrophage Activation Responses

Methods and Protocols, 2022
Macrophage activation refers to the enhanced functionality of macrophages in response to endogenous or exogenous stimuli. Due to the existence of limitless stimuli and a multitude of receptors on macrophage surfaces, the nature of activation (or acquired
Brandon W. Lewis, Sonika Patial, Yogesh Saini   +2 more
doaj   +1 more source

Macrophage Activation in Systemic Sclerosis [PDF]

JACC: Basic to Translational Science
Maria Caterina Turco, PhD, Nicoletta Del Papa, MD, Marco Vicenzi, MD, Liberato Marzullo, PhD, Alessandra Rosati, PhD, Margot De Marco, PhD   +5 more
doaj   +2 more sources