Results 1 to 10 of about 2,007,152 (308)

MAP kinase phosphatase 2 regulates macrophage-adipocyte interaction. [PDF]

PLoS ONE, 2015
Inflammation is critical for the development of obesity-associated metabolic disorders. This study aims to investigate the role of mitogen-activated protein kinase phosphatase 2 (MKP-2) in inflammation during macrophage-adipocyte interaction.White ...
Huipeng Jiao, Peng Tang, Yongliang Zhang
doaj   +1 more source

Tranglutaminase 2 contributes to the asthmatic inflammation by modulating activation of alveolar macrophages

Immunity, Inflammation and Disease, 2021
Background Transglutaminase 2 (TG2), a multifunctional calcium‐dependent acyltransferase, is upregulated in asthmatic airways and reported to play a role in the pathogenesis of allergic asthma.
Hyun Seung Lee, Da‐Eun Park, Boram Bae, Keunhee Oh, Jae Woo Jung, Dong‐Sup Lee, In‐Gyu Kim, Sang‐Heon Cho, Hye‐Ryun Kang   +8 more
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Macrophage Activation Led Acute Heart Failure Managed Successfully with Immunosuppression

Journal of Blood Medicine, 2021
Karan Seegobin,1 Muhamad Alhaj Moustafa,1 Umair Majeed,1 Jordan C Ray,2 Marwan Shaikh,1 Liuyan Jiang,3 Han W Tun1 1Department of Hematology and Medical Oncology, Mayo Clinic, Jacksonville, FL, 32224, USA; 2Departmentof Cardio-Oncology, Mayo Clinic ...
Seegobin K, Alhaj Moustafa M, Majeed U, Ray JC, Shaikh M, Jiang L, Tun HW   +6 more
doaj  

XBP1 deficiency promotes hepatocyte pyroptosis by impairing mitophagy to activate mtDNA-cGAS-STING signaling in macrophages during acute liver injury

Redox Biology, 2022
Hepatocellular cell death and macrophage proinflammatory activation contribute to the pathology of various liver diseases, during which XBP1 plays an important role.
Zheng Liu, Mingming Wang, Xun Wang, Qingfa Bu, Qi Wang, Wantong Su, Lei Li, Haoming Zhou, Ling Lu   +8 more
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Deriving a Boolean dynamics to reveal macrophage activation with in vitro temporal cytokine expression profiles

BMC Bioinformatics, 2019
Background Macrophages show versatile functions in innate immunity, infectious diseases, and progression of cancers and cardiovascular diseases. These versatile functions of macrophages are conducted by different macrophage phenotypes classified as ...
Ricardo Ramirez, Allen Michael Herrera, Joshua Ramirez, Chunjiang Qian, David W. Melton, Paula K. Shireman, Yu-Fang Jin   +6 more
doaj   +1 more source

Does early treatment of macrophage activation syndrome prevent fatal outcome in patients with severe systemic juvenile idiopathic arthritis?

Rheumatology, 2014
Macrophage activation syndrome (MAS), a rare complication of various diseases, mainly systemic inflammatory connective tissue disorders, is being increasingly recognized.
Marzena Janczewska, Teresa Kołcun-Penkowska   +1 more
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Macrophage activation unveiled [PDF]

The Journal of Experimental Medicine, 2005
In the early 1960s, George Mackaness showed that macrophages from mice infected with intracellular bacteria could launch an indiscriminate attack against unrelated bacteria. Thus began an explosion of research on the biology of what Mackaness first termed “macrophage activation.”
openaire   +2 more sources

Metabolism fine-tunes macrophage activation

eLife, 2016
A signaling pathway that rewires metabolism in macrophages to trigger changes in gene expression has been identified.
AnnMarie Torres, Liza Makowski, Kathryn E Wellen   +2 more
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Macrophage activation syndrome in COVID-19

Акушерство, гинекология и репродукция, 2021
The novel coronavirus epidemic is characterized by high rates of morbidity and relatively high mortality. Laboratory test results in patients include leukopenia, an increase in liver function tests and ferritin levels reaching hundreds, and sometimes ...
K. N. Grigorieva, V. O. Bitsadze, J. Kh. Khizroeva, M. V. Tretyakova, D. V. Blinov, V. I. Tsibizova, D. A. Ponomarev, A. S. Shkoda, E. A. Orudzhova, E. Grandone, G. Rizzo, A. D. Makatsariya   +11 more
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Metabolic Regulation of Macrophage Activation

Journal of Innate Immunity, 2021
Macrophages, the central mediators of innate immune responses, being in the first-line of defense, they have to readily respond to pathogenic or tissue damage signals to initiate the inflammatory cascade.
Ourania Kolliniati, Eleftheria Ieronymaki, Eleni Vergadi, Christos Tsatsanis   +3 more
doaj   +1 more source