Results 1 to 10 of about 116,710 (303)

Molecular Determinants of Macrophage Polarization in Glioblastoma and Implications for Tumor Progression [PDF]

Cells
Glioblastoma (GBM) is a highly aggressive brain tumor with a complex tumor microenvironment (TME) that includes immune cell infiltration, notably macrophages. The role of macrophages in GBM progression is influenced by their polarization state, which can
Xiao-Xiao Luo, Min Fu, Ben Zhao, Feng Yang, Yi-Zhou Liu, Xiao-Hong Peng, Shi-Yong Li, Gao-Feng Zhan, Ying-Jia Hu, Guang-Yuan Hu, Heng-Hui Cheng, Qian-Xia Li   +11 more
doaj   +2 more sources

Modulation of Wnt/β-catenin signaling in IL-17A-mediated macrophage polarization of RAW264.7 cells [PDF]

Brazilian Journal of Medical and Biological Research, 2020
Macrophages play pivotal roles in host defense and immune homeostasis, which have two major functional polarization states, the classically activated M1 and the alternatively activated M2.
Chao Yuan, Dandan Yang, Jia Ma, Jiali Yang, Jing Xue, Fuyang Song, Xiaoming Liu   +6 more
doaj   +1 more source

The potential role of miRNA in regulating macrophage polarization

Heliyon, 2023
Macrophage polarization is a dynamic process determining the outcome of various physiological and pathological situations through inducing pro-inflammatory responses or resolving inflammation via exerting anti-inflammatory effects.
Shaho Khayati, Sajad Dehnavi, Mahvash Sadeghi, Jalil Tavakol Afshari, Seyed-Alireza Esmaeili, Mojgan Mohammadi   +5 more
doaj   +1 more source

Ironing Out the Details: How Iron Orchestrates Macrophage Polarization

Frontiers in Immunology, 2021
Iron fine-tunes innate immune responses, including macrophage inflammation. In this review, we summarize the current understanding about the iron in dictating macrophage polarization.
Yaoyao Xia, Yaoyao Xia, Yikun Li, Xiaoyan Wu, Qingzhuo Zhang, Siyuan Chen, Xianyong Ma, Xianyong Ma, Miao Yu, Miao Yu   +9 more
doaj   +1 more source

Macrophage Polarization and Its Role in Liver Disease

Frontiers in Immunology, 2021
Macrophages are important immune cells in innate immunity, and have remarkable heterogeneity and polarization. Under pathological conditions, in addition to the resident macrophages, other macrophages are also recruited to the diseased tissues, and ...
Cheng Wang, Cheng Ma, Lihong Gong, Yuqin Guo, Ke Fu, Yafang Zhang, Honglin Zhou, Yunxia Li   +7 more
doaj   +1 more source

Changes in the Small Noncoding RNAome During M1 and M2 Macrophage Polarization

Frontiers in Immunology, 2022
Macrophages belong to a special phagocytic subgroup of human leukocytes and are one of the important cells of the human immune system. Small noncoding RNAs are a group of small RNA molecules that can be transcribed without the ability to encode proteins ...
Ding Ma, Xing Zhou, Yu Wang, Liming Dai, Jie Yuan, Jianping Peng, Xiaoling Zhang, Chuandong Wang   +7 more
doaj   +1 more source

Dental pulp stem cell-derived exosomes suppress M1 macrophage polarization through the ROS-MAPK-NFκB P65 signaling pathway after spinal cord injury

Journal of Nanobiotechnology, 2022
Stem cell-derived exosomes have recently been regarded as potential drugs for treating spinal cord injury (SCI) by reducing reactive oxygen species (ROS) and suppressing M1 macrophage polarization. However, the roles of ROS and exosomes in the process of
Chao Liu, Fanqi Hu, Genlong Jiao, Yue Guo, Pan Zhou, Yuning Zhang, Zhen Zhang, Jing Yi, Yonggang You, Zhizhong Li, Hua Wang, Xuesong Zhang   +11 more
doaj   +1 more source

Extracellular CIRP-Impaired Rab26 Restrains EPOR-Mediated Macrophage Polarization in Acute Lung Injury

Frontiers in Immunology, 2021
Acute lung injury (ALI)/acute respiratory distress syndrome (ARDS) is a condition with an imbalanced inflammatory response and delayed resolution of inflammation. Macrophage polarization plays an important role in inflammation and resolution.
Wen Zhang, Yao Wang, Chuanwei Li, Yu Xu, Xia Wang, Di Wu, Zhan Gao, Hang Qian, Zaichun You, Zhiren Zhang, Binfeng He, Binfeng He, Guansong Wang   +12 more
doaj   +1 more source

Lactate promotes Salmonella intracellular replication and systemic infection via driving macrophage M2 polarization

Microbiology Spectrum, 2023
Salmonella is one of the most important enteric pathogens worldwide, which is able to cause lethal systemic infection via survival and replication in host macrophages.
Xinyue Wang, Bin Yang, Shuangshuang Ma, Xiaolin Yan, Shuai Ma, Hongmin Sun, Yuyang Sun, Lingyan Jiang   +7 more
doaj   +1 more source

Macrophage polarization as a potential therapeutic target for atherosclerosis: a dynamic stochastic modelling study

Royal Society Open Science, 2022
We proposed a dynamic stochastic mathematical model to evaluate the role of macrophage polarization in plaque development. The dynamic process of macrophages from proliferation to death was simulated under different lipid microenvironments.
Mengchen Liu, Yan Cai, Jichao Pan, Karlheinz Peter, Zhiyong Li   +4 more
doaj   +1 more source