Results 1 to 10 of about 846,213 (256)

Stimulation of the farnesoid X receptor promotes M2 macrophage polarization [PDF]

Frontiers in Immunology, 2023
FXR is a key molecule that modulates anti-inflammatory activity in the intestinal-liver axis. Although FXR has pleiotropic functions including regulation of liver inflammation and activation of macrophages, it remains unclear whether it is involved in ...
Thiranut Jaroonwitchawan, Hideki Arimochi, Yuki Sasaki, Chieko Ishifune, Hiroyuki Kondo, Kunihiro Otsuka, Kunihiro Otsuka, Shin-ichi Tsukumo, Shin-ichi Tsukumo, Koji Yasutomo, Koji Yasutomo, Koji Yasutomo   +11 more
doaj   +6 more sources

Global characterization of macrophage polarization mechanisms and identification of M2-type polarization inhibitors [PDF]

Cell Reports, 2021
Summary: Macrophages undergoing M1- versus M2-type polarization differ significantly in their cell metabolism and cellular functions. Here, global quantitative time-course proteomics and phosphoproteomics paired with transcriptomics provide a ...
Jhih-Hua Jhong, Wilhelm Haas, Tzong-Yi Lee   +2 more
exaly   +5 more sources

Construction of a curcumin-siRNA co-delivery system based on mesoporous silica and its effect on M2-type polarization of macrophages

口腔疾病防治, 2021
Objective To fabricate a co-delivery system of curcumin (CUR) and siRNA based on mesoporous silica nanoparticles (MSN) and investigate its potential application in inducing macrophage M2 polarization.
LI Peihan, LANG Kai, SONG Wen
doaj   +1 more source

MerTK-mediated efferocytosis promotes immune tolerance and tumor progression in osteosarcoma through enhancing M2 polarization and PD-L1 expression

OncoImmunology, 2022
The poor progress of immunotherapy on osteosarcoma patients requires deeper delineation of immune tolerance mechanisms in the osteosarcoma microenvironment and a new therapeutic strategy.
Jinti Lin, Ankai Xu, Jiakang Jin, Man Zhang, Jianan Lou, Chao Qian, Jian Zhu, Yitian Wang, Zhengming Yang, Xiumao Li, Wei Yu, Bing Liu, Huimin Tao   +12 more
doaj   +1 more source

Lactate promotes Salmonella intracellular replication and systemic infection via driving macrophage M2 polarization

Microbiology Spectrum, 2023
Salmonella is one of the most important enteric pathogens worldwide, which is able to cause lethal systemic infection via survival and replication in host macrophages.
Xinyue Wang, Bin Yang, Shuangshuang Ma, Xiaolin Yan, Shuai Ma, Hongmin Sun, Yuyang Sun, Lingyan Jiang   +7 more
doaj   +1 more source

Expression of arginase 1 and tyrosine kinase Mer by blood monocytes in the dynamics of physiological pregnancy

Медицинская иммунология, 2023
During pregnancy, the maternal immune system must maintain tolerance to paternal antigens, at the same time being able to eliminate pathogens, which is achieved by the weakening of adoptive immunity and the activation of innate immunity, in particular ...
E. Ya. Shevela, N. G. Bukhtueva, M. A. Tikhonova, L. V. Sakhno, N. M. Pasman, E. R. Chernykh   +5 more
doaj   +1 more source

Tissue transglutaminase exacerbates renal fibrosis via alternative activation of monocyte-derived macrophages

Cell Death and Disease, 2023
Macrophages are important components in modulating homeostatic and inflammatory responses and are generally categorized into two broad but distinct subsets: classical activated (M1) and alternatively activated (M2) depending on the microenvironment ...
Yoshiki Shinoda, Hideki Tatsukawa, Atsushi Yonaga, Ryosuke Wakita, Taishu Takeuchi, Tokuji Tsuji, Miyako Tanaka, Takayoshi Suganami, Kiyotaka Hitomi   +8 more
doaj   +1 more source

Modulation of Wnt/β-catenin signaling in IL-17A-mediated macrophage polarization of RAW264.7 cells [PDF]

Brazilian Journal of Medical and Biological Research, 2020
Macrophages play pivotal roles in host defense and immune homeostasis, which have two major functional polarization states, the classically activated M1 and the alternatively activated M2.
Chao Yuan, Dandan Yang, Jia Ma, Jiali Yang, Jing Xue, Fuyang Song, Xiaoming Liu   +6 more
doaj   +1 more source

Restoration of Default Blood Monocyte-Derived Macrophage Polarization With Adalimumab But Not Etanercept in Rheumatoid Arthritis

Frontiers in Immunology, 2022
IntroductionWe previously reported a specific defect of rheumatoid arthritis (RA) monocyte polarization to anti-inflammatory M2-like macrophages related to increased miR-155 expression in all RA patients except those receiving adalimumab (ADA).
Audrey Paoletti, Bineta Ly, Samuel Bitoun, Samuel Bitoun, Gaëtane Nocturne, Gaëtane Nocturne, Elodie Rivière, Elodie Rivière, Jessica J. Manson, Andrea Matucci, Marc Pallardy, Marc Pallardy, Niek De Vries, Xavier Mariette, Xavier Mariette   +14 more
doaj   +1 more source

Inhibition of YAP1 activity ameliorates acute lung injury through promotion of M2 macrophage polarization

MedComm, 2023
The balance of M1/M2 macrophage polarization plays an important role in regulating inflammation during acute lung injury (ALI). Yes‐associated protein (YAP1) is a key protein in the Hippo–YAP1 signaling pathway and is involved in macrophage polarization.
Lu Liang, Wenyan Xu, Ao Shen, Xiaomei Fu, Huiyu Cen, Siran Wang, Zhongxiao Lin, Lingmin Zhang, Fangyu Lin, Xin Zhang, Na Zhou, Jishuo Chang, Zhe‐Sheng Chen, Chuwen Li, Xiyong Yu   +14 more
doaj   +1 more source