Results 1 to 10 of about 335,922 (119)

CD58 acts as a tumor promotor in hepatocellular carcinoma via activating the AKT/GSK-3β/β-catenin pathway

Journal of Translational Medicine, 2023
Background Hepatocellular carcinoma (HCC) is one of the most prevalent malignancies worldwide because of rapid progression and high incidence of metastasis or recurrence.
Chuanzheng Wang, Fei Cao, Jiahao Cao, Zhen Jiao, Yuting You, Yu Xiong, Wenxiu Zhao, Xiaomin Wang   +7 more
doaj   +1 more source

Resveratrol protects against chronic alcohol-induced liver disease in a rat model

STEMedicine, 2022
Hepatic ethanol metabolism participates in the pathogenesis of alcoholic liver disease (ALD). We aimed to evaluate the protecting effects and underlying mechanisms of Resveratrol against ALD.
Hanzhang Zhu, Jun Lu, Weijiang Zhou, Changku Jia   +3 more
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Heat shock protein HSPA13 promotes hepatocellular carcinoma progression by stabilizing TANK

Cell Death Discovery, 2023
HSPA13, an important member of the heat shock protein family, plays an essential role in the oncogenesis of many organs, but the mechanism and function in hepatocellular carcinoma (HCC) is still unclear.
Xuesong Cen, Yuyan Lu, Jing Lu, Changhong Luo, Ping Zhan, Yizhe Cheng, Fan Yang, Chengrong Xie, Zhenyu Yin, Fuqiang Wang   +9 more
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RBCK1 promotes hepatocellular carcinoma metastasis and growth by stabilizing RNF31

Cell Death Discovery, 2022
RNF31 (HOIP), RBCK1 (HOIL-1L), and SHARPIN are subunits of the linear ubiquitin chain assembly complex. Their function and specific molecular mechanisms in hepatocellular carcinoma (HCC) have not been reported previously.
Xijun Chen, Qing Ye, Wenxiu Zhao, Xiaoqin Chi, Chengrong Xie, Xiaomin Wang   +5 more
doaj   +1 more source

Long Noncoding RNA HCAL Facilitates the Growth and Metastasis of Hepatocellular Carcinoma by Acting as a ceRNA of LAPTM4B

Molecular Therapy: Nucleic Acids, 2017
Long noncoding RNAs (lncRNAs) are a new class of regulatory noncoding RNAs. Emerging evidences indicate that lncRNAs play a critical role in the development of hepatocellular carcinoma (HCC).
Cheng-Rong Xie, Fei Wang, Sheng Zhang, Fu-Qiang Wang, Sen Zheng, Zhao Li, Jie Lv, He-Qiang Qi, Qin-Liang Fang, Xiao-Min Wang, Zhen-Yu Yin   +10 more
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β-Lapachone Selectively Kills Hepatocellular Carcinoma Cells by Targeting NQO1 to Induce Extensive DNA Damage and PARP1 Hyperactivation

Frontiers in Oncology, 2021
Hepatocellular carcinoma (HCC) is the second leading cause of cancer-related death globally. Currently there is a lack of tumor-selective and efficacious therapies for hepatocellular carcinoma. β-Lapachone (ARQ761 in clinical form) selectively kill NADPH:
Wenxiu Zhao, Wenxiu Zhao, Lingxiang Jiang, Ting Fang, Fei Fang, Yingchun Liu, Ye Zhao, Yuting You, Hao Zhou, Xiaolin Su, Jiangwei Wang, Sheng Liu, Yaomin Chen, Jun Wan, Jun Wan, Xiumei Huang   +15 more
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Elevated N‐methyltransferase expression induced by hepatic stellate cells contributes to the metastasis of hepatocellular carcinoma via regulation of the CD44v3 isoform

Molecular Oncology, 2019
The cross‐talk between hepatic stellate cells (HSCs) and hepatic carcinoma cells contributes to hepatocellular carcinoma (HCC) progression, but the underlying mechanism is largely unknown.
Jie Li, Song You, Sheng Zhang, Qing Hu, Fuqiang Wang, Xiaoqin Chi, Wenxiu Zhao, Chengrong Xie, Changmao Zhang, Yaqi Yu, Jianmin Liu, Yue Zhao, Pingguo Liu, Yi Zhang, Xujin Wei, Qiu Li, Xiaomin Wang, Zhenyu Yin   +17 more
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Fibrolamellar hepatocellular carcinoma treated with atezolizumab and bevacizumab: two case reports

Journal of Medical Case Reports, 2021
Background Fibrolamellar hepatocellular carcinoma is a unique tumor of the liver that differs from the classical hepatocellular carcinoma in diagnosis, behavior, and possibly treatment.
Ali AL Zahrani, Ali Alfakeeh
doaj   +1 more source

Risk prediction for dermatomyositis-associated hepatocellular carcinoma

BMC Bioinformatics, 2023
Objective To explore dermatomyositis signature genes as potential biomarkers of hepatocellular carcinoma and their associated molecular regulatory mechanisms.
Xusheng Zhang, Yongxin Ma, Kejun Liu, Long Chen, Lin Ding, Weihu Ma, Bendong Chen   +6 more
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ZNF561 antisense RNA 1 contributes to angiogenesis in hepatocellular carcinoma through upregulation of platelet-derived growth Factor-D

Chinese Journal of Physiology, 2022
Hepatocellular carcinoma is a common malignant tumor with high recurrence rate. Long non-coding RNA (lncRNA) ZNF561 antisense RNA 1 (ZNF561-AS1) functions as an oncogenic lncRNA to promote the tumorigenesis of colorectal cancer. The role of ZNF561-AS1 in
Jihu Zheng, Zijian Guo, Zhanchao Wen, Huikang Chen   +3 more
doaj   +1 more source