Results 31 to 40 of about 846,213 (256)

RORα Induces KLF4-Mediated M2 Polarization in the Liver Macrophages that Protect against Nonalcoholic Steatohepatitis

Cell Reports, 2017
The regulation of M1/M2 polarization in liver macrophages is closely associated with the progression of nonalcoholic steatohepatitis (NASH); however, the mechanism involved in this process remains unclear.
Yong-Hyun Han, Hyeon-Ji Kim, Hyelin Na, Min-Woo Nam, Ju-Yeon Kim, Jun-Seok Kim, Seung-Hoi Koo, Mi-Ock Lee   +7 more
doaj   +1 more source

Re-polarization of immunosuppressive macrophages to tumor-cytotoxic macrophages by repurposed metabolic drugs

OncoImmunology, 2021
M2-like tumor-associated macrophages promote tumor progression by establishing an immunosuppressive tumor microenvironment. The phenotype and activity of immunosuppressive macrophages are related to their mitochondrial metabolism.
Cesar Oyarce, Ana Vizcaino-Castro, Shipeng Chen, Annemarie Boerma, Toos Daemen   +4 more
doaj   +1 more source

Ab initio and experimental studies of polarization and polarization related fields in nitrides and nitride structures

AIP Advances, 2017
Spontaneous and piezoelectric polarization in the nitrides is analyzed. The slab model was designed and proved to be appropriate to obtain the spontaneous polarization in AlN, GaN and InN.
Pawel Strak, Pawel Kempisty, Konrad Sakowski, Agata Kaminska, Dawid Jankowski, Krzysztof P. Korona, Kamil Sobczak, Jolanta Borysiuk, Mark Beeler, Ewa Grzanka, Eva Monroy, Stanislaw Krukowski   +11 more
doaj   +1 more source

GRN Activates TNFR2 to Promote Macrophage M2 Polarization Aggravating Mycobacterium Tuberculosis Infection

Frontiers in Bioscience-Landmark
Background: The polarization of macrophages plays a critical role in the immune response to infectious diseases, with M2 polarization shown to be particularly important in various pathological processes.
Bingling Zhang, Lan Xiang, Jun Chen, Jun Zhang, Renliu Dong, Guolun Mo, Feng Wu   +6 more
doaj   +1 more source

MicroRNA Let-7 Induces M2 Macrophage Polarization in COPD Emphysema Through the IL-6/STAT3 Pathway

, 2023
Tingting Liu, Zheming Zhang, Weiyu Shen, Yan Wu, Tao Bian Department of Respiratory Medicine, Wuxi People’s Hospital Affiliated to Nanjing Medical University, Wuxi, Jiangsu, 214023, People’s Republic of ChinaCorrespondence: Tao Bian; Yan Wu, Department ...
Zhang Z, Liu T, Bian T, Shen W, Wu Y
core  

Inhibitory Effects of Betulinic Acid on LPS-Induced Neuroinflammation Involve M2 Microglial Polarization via CaMKKβ-Dependent AMPK Activation

Frontiers in Molecular Neuroscience, 2018
In response to the microenvironment, microglia may polarize into either an M1 pro-inflammatory phenotype, exacerbating neurotoxicity, or an M2 anti-inflammatory phenotype, conferring neuroprotection.
Chuwen Li, Chao Zhang, Chao Zhang, Hefeng Zhou, Yu Feng, Fan Tang, Maggie P. M. Hoi, Chengwei He, Dan Ma, Chao Zhao, Simon M. Y. Lee   +10 more
doaj   +1 more source

Treatment targets for M2 microglia polarization in ischemic stroke

Biomedicine & Pharmacotherapy, 2018
As the first line of defense in the nervous system, resident microglia are the predominant immune cells in the brain. In diseases of the central nervous system such as stroke, Alzheimer's disease, and Parkinson's disease, they often cause inflammation or phagocytosis; however, some studies have found that despite the current controversy over M1, M2 ...
Ji, Wang, Hongyi, Xing, Lin, Wan, Xingjun, Jiang, Chen, Wang, Yan, Wu   +5 more
openaire   +2 more sources

Medrysone promotes corneal injury repair by promoting M2-like polarization of macrophages

BMC Ophthalmology, 2023
Background Accumulated evidence suggests that M2-like polarized macrophages plays an important role in reducing inflammation, promoting and accelerating wound healing process and tissue repair.
Yaqin Zhu, Xiaohong Jin, Ning Fu, Jiuke Li   +3 more
doaj   +1 more source

M1/M2 macrophage polarization in human obese adipose tissue [PDF]

Biomedical Papers, 2018
Obesity and insulin resistance are closely associated with chronic inflammation in adipose tissue, where macrophages play an important role. Adipose tissue macrophages can be divided into two main phenotypes: the classical M1 macrophages and alternatively activated macrophages M2. M1 macrophages produce pro-inflammatory cytokines (TNF-α, interleukin IL-
Jaroslava Chylikova, Jana Dvorackova, Zdenek Tauber, Vojtech Kamarad   +3 more
openaire   +3 more sources

Lithium silicate-based bioceramics promoting chondrocyte maturation by immunomodulating M2 macrophage polarization

, 2020
Articular cartilage lesions occur frequently but unfortunately the damaged cartilage has a very limited intrinsic repair capacity. Since the cartilage damage can cause sterile inflammation, the effects of inflammation on cartilage repair should be well ...
Zhu, Yufang, Chen, Lei, Xiao, Yin, Wu, Chengtie, Zhai, Dong, Chen, Yu   +5 more
core   +1 more source