Results 11 to 20 of about 846,213 (256)

Gremlin 1 is required for macrophage M2 polarization [PDF]

American Journal of Physiology-Lung Cellular and Molecular Physiology, 2023
We show here that gremlin 1 potentiated M2 polarization of mouse bone marrow-derived macrophages (BMDMs) in response to the Th2 cytokines IL4 and IL13. Genetic depletion of Grem1 in BMDMs inhibited M2 polarization while exogenous gremlin 1 partially rescued this effect.
Liberty Mthunzi, Simon C. Rowan, Daria S. Kostyunina, John A. Baugh, Ulla G. Knaus, Paul McLoughlin   +5 more
openaire   +4 more sources

Gold nanoparticle-directed autophagy intervention for antitumor immunotherapy via inhibiting tumor-associated macrophage M2 polarization

Acta Pharmaceutica Sinica B, 2022
Tumor-associated macrophages (TAMs), one of the dominating constituents of tumor microenvironment, are important contributors to cancer progression and treatment resistance.
Siyue Zhang, Fangyuan Xie, Kaichun Li, He Zhang, You Yin, Yuan Yu, Guangzhao Lu, Shihao Zhang, Yan Wei, Ke Xu, Yan Wu, Hong Jin, Lan Xiao, Leilei Bao, Can Xu, Yulin Li, Ying Lu, Jie Gao   +17 more
doaj   +2 more sources

A sweet alternative: maintaining M2 macrophage polarization

Science Immunology, 2018
Glycolytic metabolism functions as a backup mechanism for M2 macrophage polarization when oxidative phosphorylation is disrupted.
Anouk A J, Hamers, Asha B, Pillai
openaire   +4 more sources

Molecular Mechanisms That Influence the Macrophage M1–M2 Polarization Balance [PDF]

Frontiers in Immunology, 2014
As an essential component of innate immunity, macrophages have multiple functions in both inhibiting or promoting cell proliferation and tissue repair. Diversity and plasticity are hallmarks of macrophages. Classical M1 and alternative M2 activation of macrophages, mirroring the Th1-Th2 polarization of T cells, represent two extremes of a dynamic ...
Wang, Nan, Liang, Hongwei, Zen, Ke
openaire   +4 more sources

Branched-chain amino acid catabolism promotes M2 macrophage polarization [PDF]

Frontiers in Immunology
IntroductionDuring an immune response, macrophages undergo systematic metabolic rewiring tailored to support their functions. Branched-chain amino acid (BCAA) metabolism has been reported to modulate macrophage function; however, its role in macrophage ...
Manxi Lu, Da Luo, Zixuan Zhang, Feng Ouyang, Yihong Shi, Changyong Hu, Hang Su, Yining Li, Jiayi Zhang, Qian Gui, Tian-Shu Yang, Tian-Shu Yang, Tian-Shu Yang   +12 more
doaj   +2 more sources

SERPINB10 promotes macrophage M2 polarization and airway inflammation in asthma

Respiratory Research
Macrophage M2 polarization plays a critical role in type 2 airway inflammation in asthma. We previously reported that serine peptidase inhibitor, clade B, member 10 (SERPINB10) promotes airway eosinophilic inflammation in asthma.To investigate the role of SERPINB10 in macrophage M2 polarization and airway inflammation in asthma.The expression of ...
Lu Zhao, Wenliang Wu, Gongqi Chen, Chunli Huang, Weiqiang Kong, Wei Gu, Huiru Jie, Lingling Yi, Guohua Zhen   +8 more
openaire   +4 more sources

Microglia Polarization From M1 to M2 in Neurodegenerative Diseases [PDF]

Frontiers in Aging Neuroscience, 2022
Microglia-mediated neuroinflammation is a common feature of neurodegenerative diseases such as Alzheimer’s disease (AD), Parkinson’s disease (PD), amyotrophic lateral sclerosis (ALS), and multiple sclerosis (MS). Microglia can be categorized into two opposite types: classical (M1) or alternative (M2), though there’s a continuum of different ...
Shenrui Guo, Hui Wang, Yafu Yin
openaire   +3 more sources

Polarized M2 macrophages in dogs with visceral leishmaniasis [PDF]

Veterinary Parasitology, 2016
The objective of the present study was to analyze the skin (nasal surface and ear regions), lymph nodes (popliteal and pre-scapular), spleen and liver of dogs with visceral leishmaniasis (VL), in order to investigate the relationship between the parasite load measured as DNA copy number of Alpha gene of DNA polymerase of Leishmania infantum by ...
Pamela Rodrigues Reina Moreira, Filipe Santos Fernando, Hélio José Montassier, Marcos Rogério André, Rosemeri de Oliveira Vasconcelos   +4 more
openaire   +4 more sources

M2 macrophage polarization: a potential target in pain relief

Frontiers in Immunology, 2023
Pain imposes a significant urden on patients, affecting them physically, psychologically, and economically. Despite numerous studies on the pathogenesis of pain, its clinical management remains suboptimal, leading to the under-treatment of many pain patients.
Wenjing Zhao, Wenjing Zhao, Wenjing Zhao, Lulin Ma, Lulin Ma, Lulin Ma, Daling Deng, Daling Deng, Daling Deng, Tianhao Zhang, Tianhao Zhang, Tianhao Zhang, Linlin Han, Linlin Han, Linlin Han, Feng Xu, Feng Xu, Feng Xu, Shiqian Huang, Shiqian Huang, Shiqian Huang, Yuanyuan Ding, Yuanyuan Ding, Yuanyuan Ding, Xiangdong Chen, Xiangdong Chen, Xiangdong Chen   +26 more
openaire   +3 more sources

M2 polarization enhances silica nanoparticle uptake by macrophages [PDF]

Frontiers in Pharmacology, 2015
While silica nanoparticles have enabled numerous industrial and medical applications, their toxicological safety requires further evaluation. Macrophages are the major cell population responsible for nanoparticle clearance in vivo. The prevailing macrophage phenotype largely depends on the local immune status of the host.
Hoppstädter, Jessica, Seif, Michelle, Dembek, Anna, Cavelius, Christian, Huwer, Hanno, Kraegeloh, Annette, Kiemer, Alexandra K.   +6 more
openaire   +3 more sources