Results 41 to 50 of about 538,375 (255)

Transcriptional Control of Macrophage Polarization [PDF]

Arteriosclerosis, Thrombosis, and Vascular Biology, 2013
Macrophages are key regulators of many organ systems, including innate and adaptive immunity, systemic metabolism, hematopoiesis, vasculogenesis, malignancy, and reproduction. The pleiotropic roles of macrophages are mirrored by similarly diverse cellular phenotypes.
Derin, Tugal, Xudong, Liao, Mukesh K, Jain   +2 more
openaire   +2 more sources

Endogenous Epoxygenases Are Modulators of Monocyte/Macrophage Activity [PDF]

, 2011
Background: Arachidonic acid is metabolized through three major metabolic pathways, the cyclooxygenase, lipoxygenase and CYP450 enzyme systems. Unlike cyclooxygenase and lipoxygenases, the role of CYP450 epoxygenases in monocyte/macrophage-mediated ...
Bishop-Bailey, D, Mary C Sugden, David Bishop-Bailey, Bystrom, J, Holness Mark J., Sugden, MC, Mark J Holness, Holness, MJ, Jessica A. Wray, Wray, JA, Sugden, M C, Matthew L. Edin, Zeldin Darryl C., Zeldin, DC, Karen E Swales, Edin Matthew L., Edin, ML, Zeldin, D C, Sugden Mary C., Wray, J A, Gilroy Derek W., Swales Karen E., Darryl C Zeldin, Gilroy, DW, Derek W Gilroy, Karen E. Swales, Edin, M L, Mark J. Holness, Matthew L Edin, Derek W. Gilroy, Wray Jessica A., Gilroy, D W, Warner Timothy D., Jonas Bystrom, Warner, T D, Darryl C. Zeldin, Timothy D. Warner, Bishop-Bailey David, Bystrom Jonas, Holness, M J, Jessica A Wray, Swales, K E, Warner, TD, Timothy D Warner, Swales, KE, Mary C. Sugden   +45 more
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Leishmaniasis: Immune Cells Crosstalk in Macrophage Polarization

, 2023
Leishmaniasis is a complex infectious parasitic disease caused by protozoa of the genus Leishmania, belonging to a group of neglected tropical diseases. It establishes significant global health challenges, particularly in socio-economically disadvantaged
Tatjana S. L. Keesen, Fernanda Silva Almeida, Shayenne Eduarda Ramos Vanderley, Arthur Gomes de Andrade, Pedro Henrique de Sousa Palmeira, Edson dos Santos Silva, Ian P. G. do Amaral, Luiz Henrique Agra Cavalcante-Silva, Fernando Cézar Comberlang   +8 more
core   +1 more source

Evolutionary Aspects of Macrophages Polarization [PDF]

, 2017
Macrophages constitute a heterogeneous population of myeloid cells that are essential for maintaining homeostasis and as a first line of innate responders controlling and organizing host defenses against pathogens. Monocyte-macrophage lineage cells are among the most functionally diverse and plastic cells of the immune system.
Eva-Stina, Edholm, Kun Hyoe, Rhoo, Jacques, Robert   +2 more
openaire   +2 more sources

The plasticity and metabolic reprogramming of macrophage in ulcerative colitis

Frontiers in Immunology
Macrophages exhibit phenotypic plasticity, which plays a role in driving tissue injury and promoting mucosal repair in ulcerative colitis (UC). Intestinal macrophages originate from both embryo-derived resident cells and circulating monocytes. Macrophage
Yi Zhang, Dingquan Yang, Junnan Jiang, Dongxu Wang, Fujian Ji, Ziqian Sun   +5 more
doaj   +1 more source

High iodine promotes autoimmune thyroid disease by activating hexokinase 3 and inducing polarization of macrophages towards M1

Frontiers in Immunology, 2022
Autoimmune thyroid disease (AITD), the most common autoimmune disease, includes Graves’ disease (GD) and Hashimoto’s thyroiditis (HT). Currently, the pathogenesis of AITD is not fully understood.
Tiantian Cai, Peng Du, Lixia Suo, Xiaozhen Jiang, Qiu Qin, Ronghua Song, Xiaorong Yang, Yanfei Jiang, Jin-an Zhang   +8 more
doaj   +1 more source

Differential polarization and the expression of efferocytosis receptor MerTK on M1 and M2 macrophages isolated from coronary artery disease patients

BMC Immunology, 2021
Background Differential polarization of macrophage into M1 and M2 mediates atherosclerotic plaque clearance through efferocytosis. Higher expression of Mer proto-oncogene tyrosine kinase (MerTK) on M2 macrophage helps in maintaining macrophage ...
Fatin Najiah Mohd Idrus, Nurul Shuhadah Ahmad, Chee Hock Hoe, Maryam Azlan, Farisha Alia Norfuad, Zurkurnai Yusof, Wan Yus Haniff Wan Isa, Akbar Ali Mohamed Ali, Get Bee Yvonne-Tee   +8 more
doaj   +1 more source

MiR-19a-3p Suppresses M1 Macrophage Polarization by Inhibiting STAT1/IRF1 Pathway

Frontiers in Pharmacology, 2021
Macrophages, an important type of immune cells, are generally polarized to classically activated macrophage (M1) or alternatively activated macrophage (M2) to respond to environmental stimuli. Signal transducer and activator of transcription 1 (STAT1), a
Xiaoxiao Zhu, Xiaoxiao Zhu, Xiaoxiao Zhu, Qiang Guo, Qiang Guo, Qiang Guo, Jing Zou, Bin Wang, Zhen Zhang, Zhen Zhang, Zhen Zhang, Ran Wei, Ran Wei, Ran Wei, Lin Zhao, Lin Zhao, Lin Zhao, Yunhong Zhang, Yunhong Zhang, Chu Chu, Chu Chu, Xiaoxiao Fu, Xiaoxiao Fu, Xia Li, Xia Li, Xia Li   +25 more
doaj   +1 more source

CCL20/CCR6 Mediated Macrophage Activation and Polarization Can Promote Adenoid Epithelial Inflammation in Adenoid Hypertrophy

, 2022
Chenchen Ye,1,2 Xinxue Guo,2 Jiani Wu,2 Minhua Wang,2 Haiyan Ding,2 Xianzhi Ren1,3,4 1The First Clinical College, Nanjing University of Chinese Medicine, Nanjing, 210046, People’s Republic of China; 2Department of Pediatrics, Yixing Hospital of ...
Wang M, Ren X, Wu J, Ding H, Ye C, Guo X
core  

Lithium silicate-based bioceramics promoting chondrocyte maturation by immunomodulating M2 macrophage polarization

, 2020
Articular cartilage lesions occur frequently but unfortunately the damaged cartilage has a very limited intrinsic repair capacity. Since the cartilage damage can cause sterile inflammation, the effects of inflammation on cartilage repair should be well ...
Zhu, Yufang, Chen, Lei, Xiao, Yin, Wu, Chengtie, Zhai, Dong, Chen, Yu   +5 more
core   +1 more source