Results 51 to 60 of about 538,375 (255)

Macrophage polarization and metabolism in atherosclerosis

Cell Death & Disease, 2023
AbstractAtherosclerosis is a chronic inflammatory disease characterized by the accumulation of fatty deposits in the inner walls of vessels. These plaques restrict blood flow and lead to complications such as heart attack or stroke. The development of atherosclerosis is influenced by a variety of factors, including age, genetics, lifestyle, and ...
Hou, Pengbo, Fang, Jiankai, Liu, Zhanhong, Shi, Yufang, Agostini, Massimiliano, Bernassola, Francesca, Bove, Pierluigi, Candi, Eleonora, Rovella, Valentina, Sica, Giuseppe, Sun, Qiang, Wang, Ying, Scimeca, Manuel, Federici, Massimo, Mauriello, Alessandro, Melino, Gerry   +15 more
openaire   +4 more sources

MicroRNA Let-7 Induces M2 Macrophage Polarization in COPD Emphysema Through the IL-6/STAT3 Pathway

, 2023
Tingting Liu, Zheming Zhang, Weiyu Shen, Yan Wu, Tao Bian Department of Respiratory Medicine, Wuxi People’s Hospital Affiliated to Nanjing Medical University, Wuxi, Jiangsu, 214023, People’s Republic of ChinaCorrespondence: Tao Bian; Yan Wu, Department ...
Zhang Z, Liu T, Bian T, Shen W, Wu Y
core  

Macrophage Polarization and the Regulation of Bone Immunity in Bone Homeostasis

, 2023
Kangyi Hu, Zhengya Shang, Xiaorui Yang, Yongjie Zhang, Linzhong Cao Clinical College of Traditional Chinese Medicine, Gansu University of Chinese Medicine, Lanzhou, People’s Republic of ChinaCorrespondence: Linzhong Cao, Clinical College of Traditional ...
Yang X, Cao L, Zhang Y, Shang Z, Hu K
core  

Cholinergic Polarization of Human Macrophages

International Journal of Molecular Sciences, 2023
Macrophages serve as vital defenders, protecting the body by exhibiting remarkable cellular adaptability in response to invading pathogens and various stimuli. These cells express nicotinic acetylcholine receptors, with the α7-nAChR being extensively studied due to its involvement in activating the cholinergic anti-inflammatory pathway.
Natalia Roa-Vidal, Adriana S. Rodríguez-Aponte, José A. Lasalde-Dominicci, Coral M. Capó-Vélez, Manuel Delgado-Vélez   +4 more
openaire   +2 more sources

Macrophage polarization in peri-implantitis lesions [PDF]

Clinical Oral Investigations, 2020
Abstract Objectives To immunohistochemically characterize and correlate macrophage M1/M2 polarization status with disease severity at peri-implantitis sites. Materials and methods A total of twenty patients (n = 20 implants) diagnosed with peri-implantitis (i.e., bleeding on
Maria Elisa Galarraga-Vinueza, Karina Obreja, Ausra Ramanauskaite, Ricardo Magini, Amira Begic, Robert Sader, Frank Schwarz   +6 more
openaire   +4 more sources

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

Macrophage Polarization in Health and Disease [PDF]

The Scientific World JOURNAL, 2011
Macrophages are terminally differentiated cells of the mononuclear phagocyte system that also encompasses dendritic cells, circulating blood monocytes, and committed myeloid progenitor cells in the bone marrow. Both macrophages and their monocytic precursors can change their functional state in response to microenvironmental cues exhibiting a marked ...
Cassetta L, Cassol E, POLI , GUIDO
openaire   +3 more sources

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Regulatory factor X1 induces macrophage M1 polarization by promoting DNA demethylation in autoimmune inflammation

JCI Insight, 2023
Abnormal macrophage polarization is generally present in autoimmune diseases. Overwhelming M1 macrophage activation promotes the continuous progression of inflammation, which is one of the reasons for the development of autoimmune diseases.
Shuang Yang, Pei Du, Haobo Cui, Meiling Zheng, Wei He, Xiaofei Gao, Zhi Hu, Sujie Jia, Qianjin Lu, Ming Zhao   +9 more
doaj   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source