Results 51 to 60 of about 116,710 (303)

Macrophage Polarization in Health and Disease [PDF]

The Scientific World JOURNAL, 2011
Macrophages are terminally differentiated cells of the mononuclear phagocyte system that also encompasses dendritic cells, circulating blood monocytes, and committed myeloid progenitor cells in the bone marrow. Both macrophages and their monocytic precursors can change their functional state in response to microenvironmental cues exhibiting a marked ...
Cassetta L, Cassol E, POLI , GUIDO
openaire   +3 more sources

Targeting Macrophage Polarization for Reinstating Homeostasis following Tissue Damage [PDF]

Tissue regeneration and remodeling involve many complex stages. Macrophages are critical in maintaining micro-environmental homeostasis by regulating inflammation and orchestrating wound healing.
Alagoda, Savindu, Ghaemmaghami, Amir M., Maghami, Susan, Du, Qiran, Amir M. Ghaemmaghami, Anna Dickinson, Andrew L. Hook, Susan Maghami, Savindu Alagoda, Hook, Andrew L., Qiran Du, Dickinson, Anna, Nakuleswaran, Pruthvi, Pruthvi Nakuleswaran   +13 more
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High iodine promotes autoimmune thyroid disease by activating hexokinase 3 and inducing polarization of macrophages towards M1

Frontiers in Immunology, 2022
Autoimmune thyroid disease (AITD), the most common autoimmune disease, includes Graves’ disease (GD) and Hashimoto’s thyroiditis (HT). Currently, the pathogenesis of AITD is not fully understood.
Tiantian Cai, Peng Du, Lixia Suo, Xiaozhen Jiang, Qiu Qin, Ronghua Song, Xiaorong Yang, Yanfei Jiang, Jin-an Zhang   +8 more
doaj   +1 more source

VIP impairs acquisition of the macrophage proinflammatory polarization profile [PDF]

, 2016
This study tested the hypothesis that vasoactive intestinal peptide (VIP) is able to modify the macrophage inflammatory profile, thus supporting its therapeutic role in autoimmune diseases.
Puig-Kröger, Amaya, Carrión Caballo, Mar, Juarranz Moratilla, Yasmina, Pérez García, Selene, Pérez Gomáriz, Rosa María, Martínez Mora, María Del Carmen, Estrada Capetillo, Lizbeth, Gutiérrez Cañas, Irene   +7 more
core   +1 more source

MiR-19a-3p Suppresses M1 Macrophage Polarization by Inhibiting STAT1/IRF1 Pathway

Frontiers in Pharmacology, 2021
Macrophages, an important type of immune cells, are generally polarized to classically activated macrophage (M1) or alternatively activated macrophage (M2) to respond to environmental stimuli. Signal transducer and activator of transcription 1 (STAT1), a
Xiaoxiao Zhu, Xiaoxiao Zhu, Xiaoxiao Zhu, Qiang Guo, Qiang Guo, Qiang Guo, Jing Zou, Bin Wang, Zhen Zhang, Zhen Zhang, Zhen Zhang, Ran Wei, Ran Wei, Ran Wei, Lin Zhao, Lin Zhao, Lin Zhao, Yunhong Zhang, Yunhong Zhang, Chu Chu, Chu Chu, Xiaoxiao Fu, Xiaoxiao Fu, Xia Li, Xia Li, Xia Li   +25 more
doaj   +1 more source

Differential polarization and the expression of efferocytosis receptor MerTK on M1 and M2 macrophages isolated from coronary artery disease patients

BMC Immunology, 2021
Background Differential polarization of macrophage into M1 and M2 mediates atherosclerotic plaque clearance through efferocytosis. Higher expression of Mer proto-oncogene tyrosine kinase (MerTK) on M2 macrophage helps in maintaining macrophage ...
Fatin Najiah Mohd Idrus, Nurul Shuhadah Ahmad, Chee Hock Hoe, Maryam Azlan, Farisha Alia Norfuad, Zurkurnai Yusof, Wan Yus Haniff Wan Isa, Akbar Ali Mohamed Ali, Get Bee Yvonne-Tee   +8 more
doaj   +1 more source

Evolutionary Aspects of Macrophages Polarization [PDF]

, 2017
Macrophages constitute a heterogeneous population of myeloid cells that are essential for maintaining homeostasis and as a first line of innate responders controlling and organizing host defenses against pathogens. Monocyte-macrophage lineage cells are among the most functionally diverse and plastic cells of the immune system.
Eva-Stina, Edholm, Kun Hyoe, Rhoo, Jacques, Robert   +2 more
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The role of macrophage polarization on fibroblast behavior-an in vitro investigation on titanium surfaces. [PDF]

, 2017
OBJECTIVES This study investigated the effect of smooth and rough titanium surface topographies on macrophage polarization and their influence on gingival fibroblast behavior cultured on titanium surfaces.
Wang, Yulan, Zhang, Yufeng, Miron, Richard John, Xuzhu Wang, Richard J. Miron, Wang, Xuzhu, Bosshardt, Dieter, Yulan Wang, Dieter D. Bosshardt, Yufeng Zhang   +9 more
core   +1 more source

Macrophage Polarization in Bacterial Infections [PDF]

The Journal of Immunology, 2008
Abstract Converging studies have shown that M1 and M2 macrophages are functionally polarized in response to microorganisms and host mediators. Gene expression profiling of macrophages reveals that various Gram-negative and Gram-positive bacteria induce the transcriptional activity of a “common host response,” which includes genes ...
Benoit, Marie, Desnues, Benoit, Mege, Jean-Louis   +2 more
openaire   +3 more sources

Macrophage polarization in peri-implantitis lesions [PDF]

Clinical Oral Investigations, 2020
Abstract Objectives To immunohistochemically characterize and correlate macrophage M1/M2 polarization status with disease severity at peri-implantitis sites. Materials and methods A total of twenty patients (n = 20 implants) diagnosed with peri-implantitis (i.e., bleeding on
Maria Elisa Galarraga-Vinueza, Karina Obreja, Ausra Ramanauskaite, Ricardo Magini, Amira Begic, Robert Sader, Frank Schwarz   +6 more
openaire   +4 more sources