Results 31 to 40 of about 538,375 (255)
Macrophage Polarization is Deregulated in Haemophilia [PDF]
Thrombosis and Haemostasis, 2019 AbstractMacrophages make important contributions to inflammation and wound healing. We show here that macrophage polarization is deregulated in haemophilia in response to macrophage colony-stimulating factor (M-CSF) and partially in response to granulocyte-macrophage colony-stimulating factor (GM-CSF).
Knowles, Lynn M. +5 more
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The role of macrophage subtypes and exosomes in immunomodulation
Cellular & Molecular Biology Letters, 2022 Macrophages are influential members of the innate immune system that can be reversibly polarized by different microenvironment signals. Cell polarization leads to a wide range of features, involving the migration, development, and organization of the ...
Abdulwahab Teflischi Gharavi +3 more
doaj +1 more source
Tissue Microenvironments Define and Get Reinforced by Macrophage Phenotypes in Homeostasis or during Inflammation, Repair and Fibrosis [PDF]
, 2012 Current macrophage phenotype classifications are based on distinct in vitro culture conditions that do not adequately mirror complex tissue environments.
Anders, Hans-Joachim, Weidenbusch, Marc
core +1 more source
Human macrophage polarization in the response to [PDF]
, 2021 Infection with Mycobacterium leprae, the causative organism of leprosy, is still endemic in numerous parts of the world including the southwestern United States.
Hong, Bo-Young +6 more
core +1 more source
BMC Nephrology, 2020 Chronic kidney disease (CKD) is characterized by inflammation, injury and fibrosis. Dysregulated innate immune responses mediated by macrophages play critical roles in progressive renal injury. The differentiation and polarization of macrophages into pro-
Hewang Lee +4 more
doaj +1 more source
Macrophage Polarization in Bacterial Infections [PDF]
The Journal of Immunology, 2008 Abstract Converging studies have shown that M1 and M2 macrophages are functionally polarized in response to microorganisms and host mediators. Gene expression profiling of macrophages reveals that various Gram-negative and Gram-positive bacteria induce the transcriptional activity of a “common host response,” which includes genes ...
Benoit, Marie +2 more
openaire +3 more sources
Phagosome maturation in polarized macrophages [PDF]
Journal of Leukocyte Biology, 2014 ABSTRACTMacrophages are capable of assuming distinct, meta-stable, functional phenotypes in response to environmental cues—a process referred to as macrophage polarization. The identity and plasticity of polarized macrophage subsets as well as their functions in the maintenance of homeostasis and the progression of various pathologies have become areas
openaire +2 more sources
Polarizing Macrophages In Vitro
, 2018 Macrophages are a heterogeneous population of innate myeloid cells involved in health and disease, which are the most functionally diverse cells of the hematopoietic system. The main functions of macrophages include responding to pathogens and modulating the adaptive immune response, induction and resolution of inflammation, tissue repair, and ...
Xuan, Huang +3 more
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Phenotypic Polarization of Macrophages in Atherosclerosis [PDF]
Arteriosclerosis, Thrombosis, and Vascular Biology, 2013 Macrophages orchestrate the inflammatory response in inflamed tissues, and recent work indicates that these cells can alter their phenotypes and functions accordingly in response to changes in the microenvironment. Initial work in models of cardiovascular disease used immunologic markers to characterize macrophage phenotypes present in atherosclerotic ...
Norbert, Leitinger, Ira G, Schulman
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Targeting Macrophage Polarization for Reinstating Homeostasis following Tissue Damage [PDF]
Tissue regeneration and remodeling involve many complex stages. Macrophages are critical in maintaining micro-environmental homeostasis by regulating inflammation and orchestrating wound healing.
Alagoda, Savindu +13 more
core +1 more source