Results 11 to 20 of about 538,375 (255)
Macrophage polarization states in atherosclerosis [PDF]
Frontiers in Immunology, 2023 Atherosclerosis, a chronic inflammatory condition primarily affecting large and medium arteries, is the main cause of cardiovascular diseases. Macrophages are key mediators of inflammatory responses.
Songlin Du +10 more
core +4 more sources
Macrophage polarization in tissue fibrosis [PDF]
PeerJ, 2023 Fibrosis can occur in all major organs with relentless progress, ultimately leading to organ failure and potentially death. Unfortunately, current clinical treatments cannot prevent or reverse tissue fibrosis.
Huidan Yang +5 more
core +4 more sources
Transcriptional profiling identifies novel regulators of macrophage polarization.
PLoS ONE, 2018 Macrophages are key inflammatory immune cells that display dynamic phenotypes and functions in response to their local microenvironment. Major advances have occurred in understanding the transcriptional, epigenetic, and functional differences in various ...
Kimberline Y Gerrick +5 more
doaj +2 more sources
Macrophage Polarization Comes of Age [PDF]
Immunity, 2005 Functional polarization of macrophages into M1 or M2 cells is an operationally useful, simplified conceptual framework describing the plasticity of mononuclear phagocytes.
Alberto Mantovani, +8 more
core +7 more sources
Macrophage polarization: the epigenetic point of view
Current Opinion in Lipidology, 2014 The first functions of macrophages to be identified by Metchnikoff were phagocytosis and microbial killing. Although these are important features, macrophages are functionally very complex and involved in virtually all aspects of life, from immunity and ...
Neele, Annette E. +3 more
core +3 more sources
Artesunate Inhibits Neointimal Hyperplasia by Promoting IRF4 Associated Macrophage Polarization
Advanced ScienceVascular restenosis is a serious clinical issue initiated and aggravated by macrophage inflammation, with no effective treatments available, in cardiovascular and autoimmune diseases.
Jinlin Miao +15 more
doaj +2 more sources
Macrophage Polarity and Disease Control [PDF]
International Journal of Molecular Sciences, 2021 Macrophages are present in most human tissues and have very diverse functions. Activated macrophages are usually divided into two phenotypes, M1 macrophages and M2 macrophages, which are altered by various factors such as microorganisms, tissue microenvironment, and cytokine signals.
Suguru Kadomoto +2 more
openaire +2 more sources
Acid Dentin Lysate Modulates Macrophage Polarization and Osteoclastogenesis In Vitro. [PDF]
, 2021 Dentin prepared from extracted teeth is used as autograft for alveolar bone augmentation. Graft consolidation involves the acid lysis of dentin thereby generating a characteristic paracrine environment. Acid lysate of dentin is mimicking this environment.
Gruber, Reinhard +7 more
core +2 more sources
Metabolic Reprograming in Macrophage Polarization [PDF]
Frontiers in Immunology, 2014 Studying the metabolism of immune cells in recent years has emphasized the tight link existing between the metabolic state and the phenotype of these cells. Macrophages in particular are a good example of this phenomenon. Whether the macrophage obtains its energy through glycolysis or through oxidative metabolism can give rise to different phenotypes ...
Silvia Galván-Peña +1 more
openaire +3 more sources
Macrophage polarization and meta-inflammation [PDF]
Translational Research, 2018 Chronic overnutrition and obesity induces low-grade inflammation throughout the body. Termed "meta-inflammation," this chronic state of inflammation is mediated by macrophages located within the colon, liver, muscle, and adipose tissue. A sentinel orchestrator of immune activity and homeostasis, macrophages adopt variable states of activation as a ...
Chuan Li +5 more
openaire +2 more sources