Results 11 to 20 of about 116,710 (303)

Macrophage polarization states in atherosclerosis [PDF]

Frontiers in Immunology, 2023
Atherosclerosis, a chronic inflammatory condition primarily affecting large and medium arteries, is the main cause of cardiovascular diseases. Macrophages are key mediators of inflammatory responses. They are involved in all stages of atherosclerosis development and progression, from plaque formation to transition into vulnerable plaques, and are ...
Jiayong Wu, Shengping He, Zhengkun Song, Sikai Chen, Xuefeng Lin, Huimei Sun, Pengyu Zhou, Qinbao Peng, Songlin Du, Shaoyi Zheng, Xiu Liu   +10 more
openaire   +5 more sources

Macrophage polarization in tissue fibrosis [PDF]

PeerJ, 2023
Fibrosis can occur in all major organs with relentless progress, ultimately leading to organ failure and potentially death. Unfortunately, current clinical treatments cannot prevent or reverse tissue fibrosis. Thus, new and effective antifibrotic therapeutics are urgently needed.
Yang, Huidan, Cheng, Hao, Dai, Rongrong, Shang, Lili, Zhang, Xiaoying, Wen, Hongyan   +5 more
openaire   +4 more sources

Transcriptional profiling identifies novel regulators of macrophage polarization. [PDF]

PLoS ONE, 2018
Macrophages are key inflammatory immune cells that display dynamic phenotypes and functions in response to their local microenvironment. Major advances have occurred in understanding the transcriptional, epigenetic, and functional differences in various ...
Kimberline Y Gerrick, Elias R Gerrick, Anuj Gupta, Sarah J Wheelan, Srinivasan Yegnasubramanian, Elizabeth M Jaffee   +5 more
doaj   +2 more sources

Macrophage Polarization Comes of Age [PDF]

Immunity, 2005
Functional polarization of macrophages into M1 or M2 cells is an operationally useful, simplified conceptual framework describing the plasticity of mononuclear phagocytes. Genetic approaches have begun to shed new light on mechanisms underlying macrophage polarization and on the actual in vivo significance of polarized M2 cells ( [this issue of ...
MANTOVANI A, SICA, Antonio, LOCATI M.
openaire   +7 more sources

Macrophage polarization [PDF]

Current Opinion in Lipidology, 2014
The first functions of macrophages to be identified by Metchnikoff were phagocytosis and microbial killing. Although these are important features, macrophages are functionally very complex and involved in virtually all aspects of life, from immunity and host defense, to homeostasis, tissue repair and development.
Jan, Van den Bossche, Annette E, Neele, Marten A, Hoeksema, Menno P J, de Winther   +3 more
openaire   +3 more sources

Research progress of traditional Chinese medicine influencing macrophage polarization [PDF]

Journal of Holistic Integrative Pharmacy, 2021
[Abstract]: Recently, with advancements in science and technology, humans have found that macrophages play essential roles in many diseases, which has become a new focus of research on disease diagnosis and treatment.
Shuang GAO, Zhe-Sheng CHEN, Xuanyu CHEN, Jing LI   +3 more
doaj   +2 more sources

Artesunate Inhibits Neointimal Hyperplasia by Promoting IRF4 Associated Macrophage Polarization [PDF]

Advanced Science
Vascular restenosis is a serious clinical issue initiated and aggravated by macrophage inflammation, with no effective treatments available, in cardiovascular and autoimmune diseases.
Jinlin Miao, Yule Yong, Zhaohui Zheng, Kui Zhang, Wei Li, Jiayi Liu, Siyi Zhou, Juan‐juan Qin, Haoyang Sun, Yatao Wang, Xianghui Fu, Xing Luo, Siyu Chen, Zhi‐Gang She, Jingjing Cai, Ping Zhu   +15 more
doaj   +2 more sources

Macrophage Polarization in Atherosclerosis

Genes, 2022
The implication of the heterogeneous spectrum of pro- and anti-inflammatory macrophages (Macs) has been an important area of investigation over the last decade. The polarization of Macs alters their functional phenotype in response to their surrounding microenvironment.
Sahar Eshghjoo, Da Mi Kim, Arul Jayaraman, Yuxiang Sun, Robert C. Alaniz   +4 more
openaire   +2 more sources

Macrophage Polarity and Disease Control [PDF]

International Journal of Molecular Sciences, 2021
Macrophages are present in most human tissues and have very diverse functions. Activated macrophages are usually divided into two phenotypes, M1 macrophages and M2 macrophages, which are altered by various factors such as microorganisms, tissue microenvironment, and cytokine signals.
Suguru Kadomoto, Kouji Izumi, Atsushi Mizokami   +2 more
openaire   +2 more sources

SERPINB10 promotes macrophage M2 polarization and airway inflammation in asthma [PDF]

Respiratory Research
Background Macrophage M2 polarization plays a critical role in type 2 airway inflammation in asthma. We previously reported that serine peptidase inhibitor, clade B, member 10 (SERPINB10) promotes airway eosinophilic inflammation in asthma.
Lu Zhao, Wenliang Wu, Gongqi Chen, Chunli Huang, Weiqiang Kong, Wei Gu, Huiru Jie, Lingling Yi, Guohua Zhen   +8 more
doaj   +2 more sources