Results 21 to 30 of about 538,375 (255)
Expression of the Inhibitory CD200 Receptor Is Associated with Alternative Macrophage Activation [PDF]
, 2010 Classical macrophage activation is inhibited by the CD200 receptor (CD200R). Here, we show that CD200R expression was specifically induced on human in vitro polarized macrophages of the alternatively activated M2a subtype, generated by incubation with IL-
Brouwer, Michael S. M. +17 more
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Polarization and Repolarization of Macrophages
Journal of Clinical and Cellular Immunology, 2015 Macrophages can acquire distinct phenotypes and biological functions depending on the microenvironment and the metabolic state. Macrophages classically activated by IFN-γ and/or microbial products display an M1 phenotype characterized by high expression of interleukin (IL)-12, inducible nitric oxide synthase (iNOS) and TNF-α.
FRATERNALE, ALESSANDRA +2 more
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Macrophage polarization in kidney diseases [PDF]
Macrophage, 2015 Macrophage accumulation associates closely with the degree of renal structural injury and renal dysfunction in human kidney diseases. Depletion of macrophages reduces while adoptive transfer of macrophages worsens inflammation in animal models of the renal injury.
Shaojiang, Tian, Shi-You, Chen
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Macrophage polarization and allergic asthma [PDF]
Translational Research, 2018 Allergic asthma is associated with airway inflammation and airway hyperresponsiveness. Macrophage polarization has been shown to have a profound impact on asthma pathogenesis. On exposure to local microenvironments, recruited macrophages can be polarized into either classically activated (or M1) or alternatively activated (or M2) phenotypes. Macrophage
Arjun Saradna +4 more
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Cell Death and Disease, 2023 Reprogramming of macrophages toward an M1 phenotype is a novel strategy to induce anticancer immunity. However, the regulatory mechanisms of M1 macrophage polarization and its functional roles in nasopharyngeal carcinoma (NPC) progression need to be ...
Huai Liu +7 more
doaj +1 more source
Epigenetic control of macrophage polarization [PDF]
European Journal of Immunology, 2011 AbstractEpigenetic control of gene expression is critical for cellular differentiation and development. Macrophage development, polarization and activation are also controlled by DNA and histone modifications. This Viewpoint summarizes the recent findings on the role of histone modifications regulating macrophage polarization toward M1 and M2 subtypes.
Osamu, Takeuch, Shizuo, Akira
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Macrophage Polarization: Learning to Manage It
International Journal of Molecular Sciences, 2022 To date, four reviews and seven experimental articles have been published in this Special Issue [...]
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Metabolic-epigenetic regulation of macrophage polarization. [PDF]
, 2021 Tumor-associated macrophages polarized to an M2 phenotype (M2-TAMs) promote neo-angiogenesis, tumor-stromal matrix remodeling, and immuno-evasion, which, collectively, contribute to immunotherapeutic resistance and reduced cancer patient survival. Highly
Noe, Jordan T.
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Macrophage Polarization in Inflammatory Diseases [PDF]
International Journal of Biological Sciences, 2014 Diversity and plasticity are two hallmarks of macrophages. M1 macrophages (classically activated macrophages) are pro-inflammatory and have a central role in host defense against infection, while M2 macrophages (alternatively activated macrophages) are associated with responses to anti-inflammatory reactions and tissue remodeling, and they represent ...
Liu, Yan-Cun +3 more
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Orchestration of macrophage polarization
Blood, 2009 Abstract In this issue of Blood, Ishii and colleagues shed new, fresh light on molecular mechanisms underlying one form of macrophage activation.
A. Mantovani, M. Locati
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