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The many facets of immunometabolism. [PDF]

PLoS Biology
Immunometabolism describes more than just metabolic shifts in immune cells. A new collection of articles shines a light on the many facets of immunometabolism, exploring the effects of molecular, cellular, and systemic metabolic mechanisms in health and ...
Joanna Clarke, Claudio Mauro
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Targeting immunometabolism in cancer through pharmacological and lifestyle interventions. [PDF]

PLoS Biology
Immunometabolism, a fundamental biogenic process that supports the function of immune cells, is often disrupted in diseases such as cancer. Tackling metabolic dysregulation at a cellular level has therefore emerged as a focus in drug development. However,
Rachael Julia Yuenyinn Tan, Yalei Liu, Weixin Chen, Yuteng Liang, Guang Sheng Ling   +4 more
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Metabolic Reprogramming of Immune Cells at the Maternal-Fetal Interface and the Development of Techniques for Immunometabolism

Frontiers in Immunology, 2021
Immunity and metabolism are interdependent and coordinated, which are the core mechanisms for the body to maintain homeostasis. In tumor immunology research, immunometabolism has been a research hotspot and has achieved groundbreaking changes in recent ...
Yiqiu Wei, Jinli Ding, Jianan Li, Songchen Cai, Su Liu, Su Liu, Ling Hong, Ling Hong, Tailang Yin, Yan Zhang, Lianghui Diao, Lianghui Diao   +11 more
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Immunometabolic Signature during Respiratory Viral Infection: A Potential Target for Host-Directed Therapies

Viruses, 2023
RNA viruses are known to induce a wide variety of respiratory tract illnesses, from simple colds to the latest coronavirus pandemic, causing effects on public health and the economy worldwide.
Larissa Menezes dos Reis, Marcelo Rodrigues Berçot, Bianca Gazieri Castelucci, Ana Julia Estumano Martins, Gisele Castro, Pedro M. Moraes-Vieira   +5 more
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Administration of an LXR agonist promotes atherosclerotic lesion remodelling in murine inflammatory arthritis

Clinical & Translational Immunology, 2023
Objectives The leading cause of mortality in patients with rheumatoid arthritis is atherosclerotic cardiovascular disease (CVD). We have shown that murine arthritis impairs atherosclerotic lesion regression, because of cellular cholesterol efflux defects
Dragana Dragoljevic, Man Kit Sam Lee, Gerard Pernes, Pooranee K Morgan, Cynthia Louis, Waled Shihata, Kevin Huynh, Arina A Kochetkova, Patrick W Bell, Natalie A Mellett, Peter J Meikle, Graeme I Lancaster, Michael J Kraakman, Prabhakara R Nagareddy, Beatriz Y Hanaoka, Ian P Wicks, Andrew J Murphy   +16 more
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Nitric Oxide in Macrophage Immunometabolism: Hiding in Plain Sight

Metabolites, 2020
Nitric Oxide (NO) is a soluble endogenous gas with various biological functions like signaling, and working as an effector molecule or metabolic regulator.
Erika M. Palmieri, Christopher McGinity, David A. Wink, Daniel W. McVicar   +3 more
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Chronic capsiate supplementation increases fat-free mass and upper body strength but not the inflammatory response to resistance exercise in young untrained men: a randomized, placebo-controlled and double-blind study

Journal of the International Society of Sports Nutrition, 2021
Background Acute capsaicinoid and capsinoid supplementation has endurance and resistance exercise benefits; however, if these short-term performance benefits translate into chronic benefits when combined with resistance training is currently unknown ...
Vilton Emanoel Lopes de Moura e Silva, Jason Michael Cholewa, Ralf Jäger, Nelo Eidy Zanchi, Marcelo Conrado de Freitas, Rayane Carvalho de Moura, Esmeralda Maria Lustosa Barros, Barbara Moura Antunes, Erico Chagas Caperuto, Sergio Luiz Galan Ribeiro, Fabio Santos Lira, Marcos Antônio Pereira dos Santos, Fabrício Eduardo Rossi   +12 more
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Triacylglycerol synthesis enhances macrophage inflammatory function

Nature Communications, 2020
As macrophages switch to a proinflammatory gylcolytic state they start to generate triglyceride-rich lipid droplets, but what function these droplets have in this context is not clear.
Angela Castoldi, Lauar B. Monteiro, Nikki van Teijlingen Bakker, David E. Sanin, Nisha Rana, Mauro Corrado, Alanna M. Cameron, Fabian Hässler, Mai Matsushita, George Caputa, Ramon I. Klein Geltink, Jörg Büscher, Joy Edwards-Hicks, Erika L. Pearce, Edward J. Pearce   +14 more
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Multi-ingredient pre-workout supplementation changes energy system contribution and improves performance during high-intensity intermittent exercise in physically active individuals: a double-blind and placebo controlled study

Journal of the International Society of Sports Nutrition, 2020
Background Nutritional ergogenic aids are commonly used to boost physiological adaptations to exercise and promote greater fitness gains. However, there is a paucity of data about multi-ingredient pre-workout supplementation (MIPS). Therefore, the aim of
Caique Figueiredo, Fábio Santos Lira, Fabricio Eduardo Rossi, François Billaut, Rodrigo Loschi, Camila S. Padilha   +5 more
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Tumor Immunometabolism Characterization in Ovarian Cancer With Prognostic and Therapeutic Implications

Frontiers in Oncology, 2021
Metabolic dysregulation in the tumor microenvironment has significant impact on immune infiltration and immune responses. However, interaction between immunity and metabolism in the ovarian microenvironment requires further exploration. We constructed an
Miner Yang, Gaowen Chen, Kunjie Gao, Yifeng Wang   +3 more
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