Results 31 to 40 of about 12,525 (189)
Phytochemical Targeting of STAT3 Orchestrated Lipid Metabolism in Therapy-Resistant Cancers
Biomolecules, 2020 Lipids are critical for maintaining homeostasis and cellular metabolism. However, the dysregulation of lipid metabolism contributes to the pathogenesis of chronic inflammatory diseases and is a hallmark of several cancer types.
Carmen Tse +3 more
doaj +1 more source
Advanced Science, EarlyView.A nanobiohybrid vaccine was designed by constructing a hydrogen‐bonded organic framework coencapsulated with glucose oxidase (GOx) and tumor antigens. This nanobiohybrid vaccine executed a GOx‐catalyzed enzyme reaction that disrupted glucose metabolism and induced redox imbalance in dendritic cells, leading to autophagy‐dependent antigen cross ...
Weidong Wang +5 more
wiley +1 more source
Targeting Immunometabolism in Glioblastoma
, 2021 We have only recently begun to understand how cancer metabolism affects antitumor responses and immunotherapy outcomes. Certain immunometabolic targets have been actively pursued in other tumor types, however, glioblastoma research has been slow to ...
PE Fecci (14455875) +8 more
core
The Investigations of NPS Modulated Immunity and Immunometabolism [PDF]
, 2021 Cancers remain in the top noncommunicable diseases responsible for premature mortality. The heterogeneity among cancers and within tumors makes treating them ever more challenging.
Ruedlinger, Brittney Leigh
core +1 more source
Immunometabolism around the clock
, 2021 Almost every cell has a molecular clock, which controls gene expression on a 24-h cycle, providing circadian rhythmicity. An example of a circadian behaviour common to most organisms is the feeding/fasting cycle, which shapes whole-body metabolism ...
Mariana P Cervantes-Silva (11267437) +4 more
core +3 more sources
Effects of a workplace gymnastics program on the perception of pain in administrative workers
Discover Public HealthBackground Administrative professionals spend most of their time sitting in uncomfortable postures. These factors lead to the emergence of chronic pain, and workplace gymnastics (WG) can be presented as a strategy to minimize these problems.
Letícia Mendes de Morais +4 more
doaj +1 more source
AnimalsDogs can develop chronic inflammatory diseases that induce progressive tissue damage and illness. Delphinidin is a component of maqui (Aristotelia chilensis) and has anti-inflammatory and antioxidant effects.
Alejandra I. Hidalgo +5 more
doaj +1 more source
Advanced Science, EarlyView.Schematic illustration of ROS‐responsive TSPBA‐PVA microspheres loaded with 20‐deoxyingenol (TP/20‐DOI) for diabetic corneal wound healing: (a) fabrication and ROS‐triggered release; (b) autophagy activation and metabolic reprogramming in macrophages; (c) suppression of macrophage‐derived CXCL3/CXCL5, attenuation of neutrophil infiltration, and ...
Jiaxin Wu +20 more
wiley +1 more source
TH17–Associated Polyamine Metabolism‐Guided Nanozyme Promotes Alveolar Bone Repair in Periodontitis
Advanced Science, EarlyView.A pronounced TH17‐skewed immune response is identified in experimental periodontitis, and enrichment of the polyamine pathway is observed during TH17 differentiation, suggesting its potential as an immunometabolic target. Inspired by these findings, DFMO@Ui‐Mn is developed as a therapeutic platform combining cascade ROS scavenging with immunometabolic ...
Cheng Zhu +12 more
wiley +1 more source
Frontiers in Immunology, 2023 In obesity, adipose tissue infiltrating macrophages acquire a unique pro-inflammatory polarization, thereby playing a key role in the development of chronic inflammation and Type 2 diabetes.
Margaud Iovino +9 more
doaj +1 more source