Results 31 to 40 of about 9,434 (203)

Glycolysis Is Required for LPS-Induced Activation and Adhesion of Human CD14+CD16− Monocytes

Frontiers in Immunology, 2019
Monocytes in humans consist of 3 subsets; CD14+CD16− (classical), CD14+CD16+ (intermediate) and CD14dimCD16+ (non-classical), which exhibit distinct and heterogeneous responses to activation.
Man K. S. Lee, Man K. S. Lee, Annas Al-Sharea, Annas Al-Sharea, Waled A. Shihata, Camilla Bertuzzo Veiga, Olivia D. Cooney, Andrew J. Fleetwood, Andrew J. Fleetwood, Michelle C. Flynn, Ellen Claeson, Clovis S. Palmer, Graeme I. Lancaster, Darren C. Henstridge, John A. Hamilton, John A. Hamilton, Andrew J. Murphy   +16 more
doaj   +1 more source

SEMA4D/VEGF surface enhances endothelialization by diminished-glycolysis-mediated M2-like macrophage polarization

Materials Today Bio, 2023
Cardiovascular disease remains the leading cause of death and morbidity worldwide. Inflammatory responses after percutaneous coronary intervention led to neoathrosclerosis and in-stent restenosis and thus increase the risk of adverse clinical outcomes ...
Yuanyuan Cui, Xiaomei Jiang, Maozhu Yang, Yinglin Yuan, Zili Zhou, Xiang Gao, Guiqing Jia, Lvzhou Cao, Danni Li, Yanshuang Zhao, Xin Zhang, Gaoping Zhao   +11 more
doaj   +1 more source

Phytochemical Targeting of STAT3 Orchestrated Lipid Metabolism in Therapy-Resistant Cancers

Biomolecules, 2020
Lipids are critical for maintaining homeostasis and cellular metabolism. However, the dysregulation of lipid metabolism contributes to the pathogenesis of chronic inflammatory diseases and is a hallmark of several cancer types.
Carmen Tse, Ashleigh Warner, Rufaik Farook, James G Cronin   +3 more
doaj   +1 more source

Crosstalk Between Metabolism and Immune Activity Reveals Four Subtypes With Therapeutic Implications in Clear Cell Renal Cell Carcinoma

Frontiers in Immunology, 2022
Clear cell renal cell carcinoma (ccRCC) is characterized by metabolic dysregulation and distinct immunological signatures. The interplay between metabolic and immune processes in the tumor microenvironment (TME) causes the complexity and heterogeneity of
Yi Wang, Yi Wang, Xin-De Zheng, Xin-De Zheng, Gui-Qi Zhu, Gui-Qi Zhu, Na Li, Na Li, Chang-Wu Zhou, Chang-Wu Zhou, Chun Yang, Chun Yang, Meng-Su Zeng, Meng-Su Zeng   +13 more
doaj   +1 more source

PRMT1‐Mediated LDHA Methylation Drives STAT3 Lactylation to Orchestrate Intestinal Inflammation and Tumorigenesis

Advanced Science, EarlyView.
This study identifies an immunometabolic axis wherein SAM‐driven PRMT1 methylates LDHA, enhancing its activity. The resultant lactate induces STAT3 K709 lactylation, which stabilizes an active conformation to promote STAT3 phosphorylation and IL‐10 expression.
Hui Wang, Mengyu Zhang, Weipeng Gong, Jiaxuan Wu, Junping Zhang, Wenxiu Zhang, Yue Liu, Kui Wang, Canhua Huang, Jun Zhou, Sijin Wu, Yan Li, Tianliang Li   +12 more
wiley   +1 more source

dsRNA in immunometabolism

Oncotarget, 2015
The worldwide prevalence of obesity has reached pandemic proportions, and with it have come other associated metabolic diseases, such as insulin resistance and type 2 diabetes (T2D). Intensive research has identified the frequent coexistence of obesity with a state of inflammation in metabolic tissues such as adipose tissue and liver [1].
openaire   +2 more sources

Immunometabolism in Caenorhabditis elegans

PLOS Pathogens, 2020
Here, we discuss 5 concepts that have emerged in studies of metabolic and immune interactions in C. elegans. The major emerging theme is that the immune response and the ability to survive pathogen infection is heavily influenced by pathogen-induced changes in host metabolism.
Sarah M. Anderson, Read Pukkila-Worley
openaire   +5 more sources

Effects of a workplace gymnastics program on the perception of pain in administrative workers

Discover Public Health
Background Administrative professionals spend most of their time sitting in uncomfortable postures. These factors lead to the emergence of chronic pain, and workplace gymnastics (WG) can be presented as a strategy to minimize these problems.
Letícia Mendes de Morais, Letícia Resende Viegas, David Michel de Oliveira, Mayara Bocchi, Eduardo Vignoto Fernandes   +4 more
doaj   +1 more source

Delphinidin Exerts Immunomodulatory Effects in Canine Neutrophils and Peripheral Blood Mononuclear Cells by Limiting Tissue Damaging Mechanisms and Regulating Cytokine Responses

Animals
Dogs can develop chronic inflammatory diseases that induce progressive tissue damage and illness. Delphinidin is a component of maqui (Aristotelia chilensis) and has anti-inflammatory and antioxidant effects.
Alejandra I. Hidalgo, Macarena Vega, Denisse Maldonado, Stefanie Teuber, Rafael A. Burgos, María A. Hidalgo   +5 more
doaj   +1 more source

Wavelength‐Dependent Photobiomodulation Regulates Macrophage Polarization via Mitochondrial Dynamics and Metabolic Reprogramming

Advanced Science, EarlyView.
Light wavelength encodes distinct macrophage fates through mitochondrial and metabolic remodeling. Red 625 nm irradiation induces glycolysis, mitochondrial fission, and M1 polarization, whereas near‐infrared 850 nm irradiation promotes fatty acid oxidation, mitochondrial fusion, and M2 polarization.
Qiusheng Shi, Hao Jia, Jianfei Dong, Linhao Li, Jingqi Cao, Xun Chen, Zhenzhen Jia, Jing Na, Zhijie Yang, Xinyuan Chen, Yubo Fan, Shuhua Yue, Lisha Zheng   +12 more
wiley   +1 more source