Results 31 to 40 of about 15,033 (230)
Frontiers in Oncology, 2021 Metabolic dysregulation in the tumor microenvironment has significant impact on immune infiltration and immune responses. However, interaction between immunity and metabolism in the ovarian microenvironment requires further exploration. We constructed an
Miner Yang +3 more
doaj +1 more source
Pharmacologic or Genetic Targeting of Glutamine Synthetase Skews Macrophages toward an M1-like Phenotype and Inhibits Tumor Metastasis. [PDF]
, 2017 Glutamine-synthetase (GS), the glutamine-synthesizing enzyme from glutamate, controls important events, including the release of inflammatory mediators, mammalian target of rapamycin (mTOR) activation, and autophagy.
Castegna, Alessandra +12 more
core +14 more sources
Immunometabolism is a key factor for the persistent spontaneous elite control of HIV-1 infection [PDF]
, 2019 Approximately 25% of elite controllers (ECs) lose their virological control by mechanisms that are only partially known. Recently, immunovirological and proteomic factors have been associated to the loss of spontaneous control. Our aim was to perform a
Alba, Verónica +12 more
core +2 more sources
Cell Metabolism, 2015 Immunometabolism is a burgeoning field dissecting the contribution of key metabolic pathways to immune cell development, fate, and behavior. This SnapShot provides an overview of the metabolic requirements driving immune responses in lymphocytes, T and B cells, as well as macrophages.
Murray, Peter J. +2 more
openaire +2 more sources
Epigenetics and immunometabolism in diabetes and aging [PDF]
, 2018 Significance: A strong relationship between hyperglycemia, impaired insulin pathway and cardiovascular disease in type 2 diabetes (T2D) is linked to oxidative stress and inflammation.
Cosentino, Francesco, Guzik, Tomasz J.
core +2 more sources
Scientific Reports, 2023 Lameness is a common condition in dairy cattle caused by infectious or noninfectious agents. Joint lesions are the second most common cause of lameness and can be diagnosed in association with the presentation of digit injuries.
Carolina Manosalva +8 more
doaj +1 more source
Liver biomarkers for prognosis in COVID-19
Revista Médica del Hospital General de México, 2022 The novel coronavirus disease 2019 (COVID-19) is caused by the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). Mortality attributable to COVID-19 remains considerably high, with case fatality rates as high as 8-11%.
Salma A. Rizo-Téllez +2 more
doaj +1 more source
Diabetes, hypertension, and cardiovascular disease: clinical insights and vascular mechanisms [PDF]
, 2018 Hypertension and type 2 diabetes are common comorbidities. Hypertension is twice as frequent in patients with diabetes compared with those who do not have diabetes.
Guzik, Tomasz J. +2 more
core +1 more source
Innate Lymphoid Cell Immunometabolism [PDF]
Journal of Molecular Biology, 2017 Innate lymphoid cells (ILCs) are tissue-resident "first responders" of the immune system that function to protect epithelial barriers against pathogens and maintain tissue homeostasis. However, because ILCs are finely tuned to perturbations within tissue microenvironments, they can also contribute to host pathology when upstream activating signals are ...
Timothy E, O'Sullivan, Joseph C, Sun
openaire +2 more sources
Metabolomic profiling of macrophages determines the discrete metabolomic signature and metabolomic interactome triggered by polarising immune stimuli [PDF]
, 2018 Priming and activating immune stimuli have profound effects on macrophages, however, studies generally evaluate stimuli in isolation rather than in combination.
Achcar, Fiona +6 more
core +3 more sources