Results 1 to 10 of about 339,187 (240)
Frontiers in Pharmacology, 2022 It is well known that tumor cells rely mainly on aerobic glycolysis for energy production even in the presence of oxygen, and glycolysis is a known modulator of tumorigenesis and tumor development.
Zhenyu Li, Fangfang Ge
exaly +4 more sources
Effects of altered glycolysis levels on CD8+ T cell activation and function
Cell Death and Disease, 2023 CD8+ T cells are an important component of the body’s adaptive immune response. During viral or intracellular bacterial infections, CD8+ T cells are rapidly activated and differentiated to exert their immune function by producing cytokines.
Jiaying Cao +5 more
semanticscholar +2 more sources
Aerobic glycolysis promotes tumor immune evasion by hexokinase2-mediated phosphorylation of IκBα
Cell Metabolism, 2022 High expression of PD-L1 in tumor cells contributes to tumor immune evasion. However, whether PD-L1 expression in tumor cells is regulated by the availability of nutrients is unknown.
Dong Guo +15 more
exaly +2 more sources
Cell Metabolism, 2020 COVID-19 can result in severe lung injury. It remained to be determined why diabetic individuals with uncontrolled glucose levels are more prone to develop the severe form of COVID-19.
Ana Campos Codo +2 more
exaly +2 more sources
Increased Tumor Glycolysis Characterizes Immune Resistance to Adoptive T Cell Therapy
Cell Metabolism, 2018 SUMMARY Adoptive T cell therapy (ACT) produces durable responses in some cancer patients; however, most tumors are refractory to ACT and the molecular mechanisms underlying resistance are unclear.
Tina Cascone +2 more
exaly +2 more sources
Modulating Glycolysis to Improve Cancer Therapy
International Journal of Molecular Sciences, 2023 Cancer cells undergo metabolic reprogramming and switch to a ‘glycolysis-dominant’ metabolic profile to promote their survival and meet their requirements for energy and macromolecules.
C. Chelakkot +3 more
semanticscholar +1 more source
Lactate is a bridge linking glycolysis and autophagy through lactylation
Autophagy, 2023 Lactate is a glycolysis product that is produced from pyruvate by LDH (lactate dehydrogenase) and plays an important role in physiological and pathological processes. However, whether lactate regulates autophagy is still unknown.
Weixia Sun +3 more
semanticscholar +1 more source
International Journal on Biological Sciences, 2023 The triggering receptor expressed on myeloid cells-1 (TREM-1) is a pro-inflammatory immune receptor potentiating acute lung injury (ALI). However, the mechanism of TREM-1-triggered inflammation response remains poorly understood.
W. Zhong +10 more
semanticscholar +1 more source
CTLA-4 blockade drives loss of Treg stability in glycolysis-low tumors
Nature, 2021 Limiting metabolic competition in the tumour microenvironment may increase the effectiveness of immunotherapy. Owing to its crucial role in the glucose metabolism of activated T cells, CD28 signalling has been proposed as a metabolic biosensor of T ...
R. Zappasodi +23 more
semanticscholar +1 more source