Frontiers in Pharmacology, 2022 It is well known that tumor cells rely mainly on aerobic glycolysis for energy production even in the presence of oxygen, and glycolysis is a known modulator of tumorigenesis and tumor development.
Daoying Zhou +8 more
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The activation of the metabolic oxaloacetate-pyruvate axis restores influenza A virus replication during impaired glycolysis [PDF]
Virology JournalViruses strongly depend on the host cell for efficient replication and influenza A virus (IAV) amongst others also lead to remarkable changes of the host cell metabolism.
Chiara Robin Bojarzyn +5 more
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Glycolysis in the control of blood glucose homeostasis
Acta Pharmaceutica Sinica B, 2012 Glycolysis, a simple pathway of glucose metabolism, critically regulates insulin secretion and metabolic functions of various cells. Depending on cell types, rates of glycolysis are determined at various steps of glycolysis that are subjected to the ...
Chaodong Wu, Hang Xu, Alex J Lange
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Interaction networks of macrophage glycolysis and inflammation in sepsis: mechanisms and therapeutic potential [PDF]
Frontiers in ImmunologySepsis is a severe threat to human health with high mortality rates, but so far its pathogenesis is unclear and lacks effective therapeutic drugs. Macrophages function as one of the most important innate immune cells and play an integral role in the ...
Peiyao Luo +5 more
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Role of glycolysis in retinal vascular endothelium, glia, pigment epithelium, and photoreceptor cells and as therapeutic targets for related retinal diseases [PDF]
International Journal of Ophthalmology, 2021 Glycolysis produces large amounts of adenosine triphosphate (ATP) in a short time. The retinal vascular endothelium feeds itself primarily through aerobic glycolysis with less ATP.
Ting-Ting Yang, Hui Li, Li-Jie Dong
doaj +1 more source
A prediction model identifying glycolysis signature as therapeutic target for psoriasis
Frontiers in Immunology, 2023 BackgroundThe hyperproliferation featured with upregulated glycolysis is a hallmark of psoriasis. However, molecular difference of keratinocyte glycolysis amongst varied pathologic states in psoriasis remain elusive.ObjectivesTo characterize glycolysis ...
Yanhong Shou +3 more
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Frontiers in Immunology, 2022 Alzheimer’s disease (AD) is a common neurodegenerative disorder without an effective treatment, and results in an increasingly serious health problem. However, its pathogenesis is complex and poorly understood.
Zhiqiang Qiu +8 more
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Effects of altered glycolysis levels on CD8+ T cell activation and function
Cell Death and Disease, 2023 CD8+ T cells are an important component of the body’s adaptive immune response. During viral or intracellular bacterial infections, CD8+ T cells are rapidly activated and differentiated to exert their immune function by producing cytokines.
Jiaying Cao +5 more
doaj +1 more source
Natural products targeting glycolysis in cancer
Frontiers in Pharmacology, 2022 Many energy metabolism pathways exist in cancer, including glycolysis, amino acid metabolism, fatty acid oxidation, and mitochondrial respiration. Tumor cells mainly generate energy through glycolysis to maintain growth and biosynthesis of tumor cells ...
Yuanyuan Zhao +5 more
doaj +1 more source
Integrated analysis reveals critical glycolytic regulators in hepatocellular carcinoma
Cell Communication and Signaling, 2020 Background Cancer cells primarily utilize aerobic glycolysis for energy production, a phenomenon known as the Warburg effect. Increased aerobic glycolysis supports cancer cell survival and rapid proliferation and predicts a poor prognosis in cancer ...
Chenying Lu +14 more
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