Results 41 to 50 of about 339,187 (240)

Proteomic analysis of the Plasmodium male gamete reveals the key role for glycolysis in flagellar motility. [PDF]

, 2014
BACKGROUND: Gametogenesis and fertilization play crucial roles in malaria transmission. While male gametes are thought to be amongst the simplest eukaryotic cells and are proven targets of transmission blocking immunity, little is known about their ...
Mara Lawniczak, Wass, Mark N., Arthur M Talman, Sinden, Robert E., Prieto, Judith H, Yates, JR, Talman, Arthur M, Sinden, Robert, Michael JE Sternberg, Sinden, Robert E, Stanway, RS, Graham, David R, Marques, S, Ubaida-Mohien, Ceereena, Tao Xu, Marques, Sara, Ecker, A, Sternberg, MJ, Sternberg, Michael J E, Yates, John R., III, Prieto, JH, Talman, AM, Rhoel R Dinglasan, Xu, T, Ubaida-Mohien, C, Sanjeev Krishna, Lawniczak, Mara, Wass, MN, Wass, Mark N, Dinglasan, Rhoel R, Robert E Sinden, Talman, Arthur M., Christophides, Georges K., Christophides, Georges K, Andrea Ecker, Sara Marques, Ceereena Ubaida-Mohien, Sternberg, Michael JE, Limenitakis Stanway, Rebecca, Dinglasan, Rhoel R., Georges K Christophides, Sternberg, MJE, Yates, John R, Roland Frank, Stanway, Rebecca S., Graham, David R., Xu, Tao, Frank, Roland, Prieto, Judith H., Rebecca S Stanway, Dinglasan, RR, John R Yates, Sternberg, Michael J. E., Stanway, Rebecca S, Graham, DR, Krishna, S, Mark N Wass, Christophides, GK, Lawniczak, M, Sinden, RE, Frank, R, Krishna, Sanjeev, Ecker, Andrea, David R Graham, Judith H Prieto   +64 more
core   +1 more source

The roles of glycolysis in osteosarcoma

Frontiers in Pharmacology, 2022
Metabolic reprogramming is of great significance in the progression of various cancers and is critical for cancer progression, diagnosis, and treatment.
Zuxi Feng, Yanghuan Ou, Liang Hao
doaj   +1 more source

Limits and Tradeoffs in the Control of Autocatalytic Systems [PDF]

, 2013
Despite the complexity of biological networks, we find that certain common architectures govern network structures. These architectures impose fundamental constraints on system performance and create tradeoffs that the system must balance in the face of ...
Chandra, Fiona Adriani
core   +1 more source

mTORC1-Induced HK1-Dependent Glycolysis Regulates NLRP3 Inflammasome Activation

Cell Reports, 2015
The mammalian target of rapamycin complex 1 (mTORC1) regulates activation of immune cells and cellular energy metabolism. Although glycolysis has been linked to immune functions, the mechanisms by which glycolysis regulates NLRP3 inflammasome activation ...
Jong-Seok Moon, Shu Hisata, Mi-Ae Park, Gina M. DeNicola, Stefan W. Ryter, Kiichi Nakahira, Augustine M.K. Choi   +6 more
doaj   +1 more source

Interactions between NLRP3 inflammasome and glycolysis in macrophages: New insights into chronic inflammation pathogenesis

Immunity, Inflammation and Disease, 2022
NLRP3 inflammasome activation in macrophages fuels sterile inflammation, which has been tied with metabolic reprogramming characterized by high glycolysis and low oxidative phosphorylation.
Qun Yu, Maojuan Guo, Wenyun Zeng, Miao Zeng, Xiaolu Zhang, Yue Zhang, Wenlan Zhang, Xijuan Jiang, Bin Yu   +8 more
doaj   +1 more source

C/EBPβ-LIP mediated activation of the malate-aspartate shuttle sensitizes cells to glycolysis inhibition

Molecular Metabolism, 2023
Objective: Cancer cells use glycolysis for generation of metabolic intermediates and ATP needed for cell growth and proliferation. The transcription factor C/EBPβ-LIP stimulates glycolysis and mitochondrial respiration in cancer cells.
Tobias Ackermann, Hidde R. Zuidhof, Christine Müller, Gertrud Kortman, Martijn G.S. Rutten, Mathilde J.C. Broekhuis, Mohamad Amr Zaini, Götz Hartleben, Cornelis F. Calkhoven   +8 more
doaj   +1 more source

Exosome‐delivered circRNA promotes glycolysis to induce chemoresistance through the miR‐122‐PKM2 axis in colorectal cancer

Molecular Oncology, 2020
Malignant tumors, including colorectal cancer (CRC), usually rely on ATP generation through aerobic glycolysis for both rapid growth and chemotherapy resistance.
Xinyi Wang, Haiyang Zhang, Haiou Yang, M. Bai, T. Ning, T. Deng, Rui Liu, Q. Fan, Kegan Zhu, Jialu Li, Yang Zhan, G. Ying, Y. Ba   +12 more
semanticscholar   +1 more source

PKM2 coordinates glycolysis with mitochondrial fusion and oxidative phosphorylation

Protein & Cell, 2019
A change in the metabolic flux of glucose from mitochondrial oxidative phosphorylation (OXPHOS) to aerobic glycolysis is regarded as one hallmark of cancer. However, the mechanisms underlying the metabolic switch between aerobic glycolysis and OXPHOS are
Tong Li, Jinbo Han, Liangjie Jia, Xiao Hu, Liqun Chen, Yiguo Wang   +5 more
doaj   +1 more source

Positive feedback regulation between glycolysis and histone lactylation drives oncogenesis in pancreatic ductal adenocarcinoma

Molecular Cancer
Metabolic reprogramming and epigenetic alterations contribute to the aggressiveness of pancreatic ductal adenocarcinoma (PDAC). Lactate-dependent histone modification is a new type of histone mark, which links glycolysis metabolite to the epigenetic ...
Fei Li, Wenzhe Si, Li Xia, Deshan Yin, Tianjiao Wei, M. Tao, Xiaona Cui, Jin Yang, T. Hong, Rui Wei   +9 more
semanticscholar   +1 more source

Increased demand for NAD+ relative to ATP drives aerobic glycolysis

bioRxiv, 2020
Aerobic glycolysis, or preferential fermentation of glucose-derived pyruvate to lactate despite available oxygen, is a hallmark of proliferative metabolism that is observed across many organisms and conditions. To better understand why aerobic glycolysis
Alba Luengo, Zhaoqi Li, D. Y. Gui, Lucas B. Sullivan, Maria Zagorulya, Brian T. Do, R. Ferreira, Adi Naamati, A. Ali, C. Lewis, Craig J. Thomas, S. Spranger, N. Matheson, M. V. Vander Heiden   +13 more
semanticscholar   +1 more source