Results 41 to 50 of about 291,093 (299)

L‐aspartate oxidase provides new insights into fumarate reduction in anaerobic darkness in Synechocystis sp. PCC6803

FEBS Letters, EarlyView.
Synechocystis strains deficient in succinate dehydrogenase (SDH) secrete more succinate than the WT under dark anaerobic conditions, supporting that SDH then primarily acts as SDH, not as a fumarate reductase. L‐aspartate oxidase (Laspo) from Synechocystis is functional under anaerobic conditions, reducing fumarate to succinate.
Kateryna Kukil, Jeffrey A. Hawkes, Cecilia Blikstad, Pia Lindberg   +3 more
wiley   +1 more source

Targeting Glycolysis in Alloreactive T Cells to Prevent Acute Graft-Versus-Host Disease While Preserving Graft-Versus-Leukemia Effect

Frontiers in Immunology, 2022
Alloreactive donor T cells undergo extensive metabolic reprogramming to become activated and induce graft-versus-host disease (GVHD) upon alloantigen encounter.
Ying Huang, Yujing Zou, Yiqun Jiao, Peijie Shi, Xiaoli Nie, Wei Huang, Chuanfeng Xiong, Michael Choi, Charles Huang, Andrew N. Macintyre, Amanda Nichols, Fang Li, Chuan-Yuan Li, Chuan-Yuan Li, Chuan-Yuan Li, Nancie J. MacIver, Nancie J. MacIver, Nancie J. MacIver, Diana M. Cardona, Todd V. Brennan, Zhiguo Li, Nelson J. Chao, Nelson J. Chao, Nelson J. Chao, Nelson J. Chao, Jeffrey C. Rathmell, Benny J. Chen, Benny J. Chen   +27 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Enhanced glycolysis is associated with aggressive tumor phenotype and worse outcomes in hepatocellular carcinoma patients

Frontiers in Medicine
BackgroundAdenosine Triphosphate (ATP) is mainly generated by oxidative phosphorylation in non-malignant cells, whereas malignant cells rely predominantly on glycolysis for energy production, known as the “Warburg effect.” This study used the gene set ...
Masanori Oshi, Masanori Oshi, Colin Rog, Li Yan, Itaru Endo, Kazuaki Takabe, Kazuaki Takabe, Kazuaki Takabe, Kazuaki Takabe   +8 more
doaj   +1 more source

2-Deoxyglucose alleviates migraine-related behaviors by modulating microglial inflammatory factors in experimental model of migraine

Frontiers in Neurology, 2023
BackgroundTargeting metabolic pathways has emerged as a new migraine treatment strategy as researchers realize the critical role metabolism plays in migraine. Activated inflammatory cells undergo metabolic reprogramming and rely on glycolysis to function.
Tao Qiu, Yanjie Zhou, Luyu Hu, Zhengming Shan, Yu Zhang, Yuting Fang, Wanbin Huang, Lily Zhang, Shanghua Fan, Zheman Xiao   +9 more
doaj   +1 more source

The multifaceted roles of lysosomes in cancer

Molecular Oncology, EarlyView.
Lysosomes support cancer cell adaptation by integrating macromolecule degradation and nutrient recycling with nutrient sensing, inter‐organelle communication and immune regulation. These interconnected functions can promote tumour growth, stress tolerance and therapy resistance, while also creating context‐dependent vulnerabilities that may be ...
Jia Li, Kevin M. Ryan
wiley   +1 more source

PFKM inhibits doxorubicin-induced cardiotoxicity by enhancing oxidative phosphorylation and glycolysis

Scientific Reports, 2022
Heart failure (HF) is a global pandemic which affects about 26 million people. PFKM (Phosphofructokinase, Muscle), catalyzing the phosphorylation of fructose-6-phosphate, plays a very important role in cardiovascular diseases. However, the effect of PFKM
Min Zhou, Xiao Sun, Chunli Wang, Fengdan Wang, Chuibi Fang, Zhenlei Hu   +5 more
doaj   +1 more source

Potassium ions promote hexokinase-II dependent glycolysis [PDF]

, 2021
High expression levels of mitochondria-associated hexokinase-II (HKII) represent a hallmark of metabolically highly active cells such as fast proliferating cancer cells. Typically, the enzyme provides a crucial metabolic switch towards aerobic glycolysis.
Burgstaller, Sandra, Springer, Anna, Lukowski, Robert, Groschner, Klaus, Bachkoenig, Olaf A., Madl, Tobias, Rauter, Thomas, Malli, Roland, Schmidt, Tony, Graier, Wolfgang F., Bischof, Helmut, Plesnila, Nikolaus, Schindl, Rainer, Matt, Lucas, Lucas Matt, Anna Springer, Klaus Groschner, Rainer Schindl, Wolfgang F. Graier, Tobias Madl, Robert Lukowski, Tony Schmidt, Helmut Bischof, Olaf A. Bachkönig, Roland Malli, Sandra Burgstaller, Nikolaus Plesnila, Thomas Rauter   +27 more
core   +1 more source

An outer membrane vesicle‐associated two‐track model for enterotoxigenic Bacteroides fragilis oncogenesis

Molecular Oncology, EarlyView.
Enterotoxigenic Bacteroides fragilis is a gut bacterium linked to bowel cancer. We propose that its toxin acts along two routes: at the cell surface, cutting the adhesion protein E‐cadherin and triggering inflammation; and inside the cell, delivered by bacterial vesicles, switching on NOD1 and cancer stem cell programs.
Kangchan Choi, Sang‐Hyeon Yoo, Ki‐Jong Rhee   +2 more
wiley   +1 more source

A bioenergetic understanding of “aerobic glycolysis”

Communications Biology
“Aerobic glycolysis” is a widely used term whose current meaning has drifted from its original usage in a way that has created confusion and inaccuracy. This drift has weakened “aerobic glycolysis” as a hypothesis-testing framework, despite the critical ...
Valerie L. Wasem, Shona A. Mookerjee
doaj   +1 more source