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Frontiers in Pharmacology, 2021 The Syrian golden hamster (Mesocricetus auratus) has recently been demonstrated as a clinically relevant animal model for SARS-CoV-2 infection. However, lack of knowledge about the tissue-specific expression pattern of various proteins in these animals ...
Voddu Suresh +9 more
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Treatment with oncolytic vaccinia virus infects tumor-infiltrating regulatory and exhausted T cells
Journal for ImmunoTherapy of CancerBackground Oncolytic viruses (OVs) are an attractive way to increase immune infiltration into an otherwise cold tumor. While OVs are engineered to selectively infect tumor cells, there is evidence that they can infect other non-malignant cells in the ...
Greg M Delgoffe +3 more
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Functional and mechanistic studies reveal MAGEA3 as a pro-survival factor in pancreatic cancer cells
Journal of Experimental & Clinical Cancer Research, 2019 Background In the era of personalized therapy, functional annotation of less frequent genetic aberrations will be instrumental in adapting effective therapeutic in clinic.
Biswajit Das, Shantibhusan Senapati
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Cell Death and Disease, 2023 Metastasis remains major cause of treatment failure in non-small cell lung cancer (NSCLC). A comprehensive characterization of the transcriptomic landscape of NSCLC-cells with organ-specific metastatic potentials would advance our understanding of NSCLC ...
Lingling Zu +5 more
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Neutrophils in the Tumor Microenvironment [PDF]
Trends in Immunology, 2016 Neutrophils are the first responders to sites of acute tissue damage and infection. Recent studies suggest that in addition to neutrophil apoptosis, resolution of neutrophil inflammation at wounds can be mediated by reverse migration from tissues and transmigration back into the vasculature.
Davalyn R, Powell, Anna, Huttenlocher
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Neutrophils in the Tumor Microenvironment [PDF]
, 2020 Neutrophils are the first responders to inflammation, infection, and injury. As one of the most abundant leukocytes in the immune system, neutrophils play an essential role in cancer progression, through multiple mechanisms, including promoting angiogenesis, immunosuppression, and cancer metastasis.
Lingyun, Wu +2 more
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Tumor microenvironment and progression [PDF]
Journal of Surgical Oncology, 2011 AbstractTumor blood vessels are heterogeneous, of at least six distinct types, are induced primarily by vascular endothelial growth factor‐A (VEGF‐A), and provide a potentially useful therapeutic target. Breast cancer is characterized by changes in the microenvironment that result in altered tensional homeostasis.
Dvorak, Harold F +3 more
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Tumor Microenvironment in the Brain [PDF]
Cancers, 2012 In addition to malignant cancer cells, tumors contain a variety of different stromal cells that constitute the tumor microenvironment. Some of these cell types provide crucial support for tumor growth, while others have been suggested to actually inhibit tumor progression.
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The potential of miR-29 in modulating tumor angiogenesis: a comprehensive review
Discover OncologyMicroRNAs (miRNAs) are a class of short non-coding RNAs that play a crucial role in the post-transcriptional regulation of gene expression. They are associated with various biological processes related to tumors.
Rui-Ting Zhou +4 more
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Tumor microenvironment antigens
Seminars in Immunopathology, 2022 AbstractThe identification and characterization of tumor antigens are central objectives in developing anti-cancer immunotherapy. Traditionally, tumor-associated antigens (TAAs) are considered relatively restricted to tumor cells (i.e., overexpressed proteins in tumor cells), whereas tumor-specific antigens (TSAs) are considered unique to tumor cells ...
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