Results 1 to 10 of about 512,927 (317)

Drug-induced lactate confers ferroptosis resistance via p38-SGK1-NEDD4L-dependent upregulation of GPX4 in NSCLC cells

Cell Death Discovery, 2023
Ferroptosis is a newly defined non-apoptotic programmed cell death resulting from the accumulation of lipid peroxides. Whether ferroptosis plays any role in chemotherapy remains to be established.
Feng Cheng, Jintao Dou, Yi Yang, Shaojie Sun, Ruiqi Chen, Zhijian Zhang, Huijun Wei, Jianhui Li, Zhihao Wu   +8 more
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Predicting the Progress of Tuberculosis by Inflammatory Response-Related Genes Based on Multiple Machine Learning Comprehensive Analysis

Journal of Immunology Research, 2023
Background. Tuberculosis (TB), caused by the bacterium Mycobacterium tuberculosis, affects approximately one-quarter of the global population and is considered one of the most lethal infectious diseases worldwide.
Shuai Ma, Peifei Peng, Zhihao Duan, Yifeng Fan, Xinzhi Li   +4 more
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KDM1A Identified as a Potential Oncogenic Driver and Prognostic Biomarker via Multi-Omics Analysis

Canadian Journal of Infectious Diseases and Medical Microbiology, 2021
Background. Lysine-specific demethylase 1A (KDM1A) is a histone demethylation enzyme and a crucial epigenetic factor for multiple pathological pathways that mediate carcinogenesis and immunogenicity.
Lingyue Li, Yiyu Wang, Yuan Mou, Hao Wu, Ye Qin   +4 more
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Lactate-induced MRP1 expression contributes to metabolism-based etoposide resistance in non-small cell lung cancer cells

Cell Communication and Signaling, 2020
Background Metabolic reprogramming contributes significantly to tumor development and is tightly linked to drug resistance. The chemotherapeutic agent etoposide (VP-16) has been used clinically in the treatment of lung cancer but possess different ...
Qi Dong, Chenkang Zhou, Haodong Ren, Zhijian Zhang, Feng Cheng, Zhenkai Xiong, Chuantao Chen, Jianke Yang, Jiguang Gao, Yao Zhang, Lei Xu, Jian Fang, Yuxiang Cao, Huijun Wei, Zhihao Wu   +14 more
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Biochanin A inhibits lung adenocarcinoma progression by targeting ZEB1

Discover Oncology, 2022
Lung adenocarcinoma is the major subtype of lung cancer, accounting for approximately 40% of lung cancers. During clinical treatment, the emergence of chemotherapy resistance seriously affects the effectiveness of treatment.
Jianjun Li, Yaqi Kou, Xiaohan Zhang, Xuechun Xiao, Yang Ou, Lixia Cao, Min Guo, Chunchun Qi, Zhaoyang Wang, Yuxin Liu, Qiuying Shuai, Hang Wang, Shuang Yang   +12 more
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Screening of Molecular Markers of Cisplatin Resistance in Lung Adenocarcinoma and Functional Verification Based on TCGA Database

Zhongliu Fangzhi Yanjiu, 2022
Objective To explore the related genes that play a key regulatory role in cisplatin resistance in lung adenocarcinoma. Methods Bioinformatics methods were used to download the differentially-expressed genes between cisplatin sensitive group and drug ...
WANG Lin, HUANG Zixian, YOU Chengcheng, TAN Shunzi, HUANG Liming, HUANG Yiling   +5 more
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The emerging roles of MAPK-AMPK in ferroptosis regulatory network

Cell Communication and Signaling, 2023
Ferroptosis, a newform of programmed cell death, driven by peroxidative damages of polyunsaturated-fatty-acid-containing phospholipids in cellular membranes and is extremely dependent on iron ions, which is differs characteristics from traditional cell ...
Xinyue Wang, Xiao Tan, Jinping Zhang, Jiaping Wu, Hongjuan Shi   +4 more
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Firing up the cold tumors by targeting Vps34

OncoImmunology, 2020
Cancer immunotherapy based on anti-PD-1/PD-L1 blockade is particularly effective in responding to patients with hot tumors. These tumors are characterized by the accumulation of proinflammatory cytokines and T cell infiltration.
Bassam Janji, Meriem Hasmim, Santiago Parpal, Guy Berchem, Muhammad Zaeem Noman   +4 more
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Gene delivery to breast cancer by incorporated EpCAM targeted DARPins into AAV2

BMC Cancer, 2023
Objective The aim of this study is to evaluate an AAV vector that can selectively target breast cancer cells and to investigate its specificity and anti-tumor effects on breast cancer cells both in vitro and in vivo, offering a new therapeutic approach ...
Ya-feng Lv, Hao Zhang, Zhi Cui, Cui-jiao Ma, Yu-ling Li, Hua Lu, Hong-yan Wu, Jian-lin Yang, Chun-yu Cao, Wen-zheng Sun, Xiao-fei Huang   +10 more
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Focal Adhesion Kinase Promotes Hepatic Stellate Cell Activation by Regulating Plasma Membrane Localization of TGFβ Receptor 2

Hepatology Communications, 2020
Transforming growth factor β (TGFβ) induces hepatic stellate cell (HSC) differentiation into tumor‐promoting myofibroblast, although underlying mechanism remains incompletely understood.
Yunru Chen, Qing Li, Kangsheng Tu, Yuanguo Wang, Xianghu Wang, Dandan Liu, Chen Chen, Donglian Liu, Rendong Yang, Wei Qiu, Ningling Kang   +10 more
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