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The Tumor Microenvironment

Indian Journal of Medical and Paediatric Oncology, 2020
A tumor is not simply a group of cancer cells, but rather a heterogeneous collection of infiltrating and resident host cells, secreted factors and extracellular matrix. Tumor cells stimulate significant molecular, cellular and physical changes within their host tissues to support tumor growth and progression.
Azgar Abdul Rasheed, Venkata Pradeep Babu Koyyala   +1 more
openaire   +4 more sources

Unraveling the epigenetic code in cancer cell-tumor microenvironment crosstalk. [PDF]

Mol Oncol
Epigenetic regulation is a key driver of cancer development and progression. Diverse epigenetic alterations in cancer cells and components of the tumor microenvironment (TME) orchestrate their communication through multiple mechanisms. We discuss how the epigenetic code coordinates bidirectional cancer cell–TME crosstalk to promote cancer progression ...
Park JH, Kim MY.
europepmc   +2 more sources

Drug-induced lactate confers ferroptosis resistance via p38-SGK1-NEDD4L-dependent upregulation of GPX4 in NSCLC cells

Cell Death Discovery, 2023
Ferroptosis is a newly defined non-apoptotic programmed cell death resulting from the accumulation of lipid peroxides. Whether ferroptosis plays any role in chemotherapy remains to be established.
Feng Cheng, Jintao Dou, Yi Yang, Shaojie Sun, Ruiqi Chen, Zhijian Zhang, Huijun Wei, Jianhui Li, Zhihao Wu   +8 more
doaj   +1 more source

Tumor Microenvironment [PDF]

Medicina, 2019
Background and Objectives: The tumor microenvironment has been widely implicated in tumorigenesis because it harbors tumor cells that interact with surrounding cells through the circulatory and lymphatic systems to influence the development and progression of cancer.
Arneth, Borros, Justus Liebig University Giessen   +1 more
openaire   +5 more sources

Predicting the Progress of Tuberculosis by Inflammatory Response-Related Genes Based on Multiple Machine Learning Comprehensive Analysis

Journal of Immunology Research, 2023
Background. Tuberculosis (TB), caused by the bacterium Mycobacterium tuberculosis, affects approximately one-quarter of the global population and is considered one of the most lethal infectious diseases worldwide.
Shuai Ma, Peifei Peng, Zhihao Duan, Yifeng Fan, Xinzhi Li   +4 more
doaj   +1 more source

KDM1A Identified as a Potential Oncogenic Driver and Prognostic Biomarker via Multi-Omics Analysis

Canadian Journal of Infectious Diseases and Medical Microbiology, 2021
Background. Lysine-specific demethylase 1A (KDM1A) is a histone demethylation enzyme and a crucial epigenetic factor for multiple pathological pathways that mediate carcinogenesis and immunogenicity.
Lingyue Li, Yiyu Wang, Yuan Mou, Hao Wu, Ye Qin   +4 more
doaj   +1 more source

Lactate-induced MRP1 expression contributes to metabolism-based etoposide resistance in non-small cell lung cancer cells

Cell Communication and Signaling, 2020
Background Metabolic reprogramming contributes significantly to tumor development and is tightly linked to drug resistance. The chemotherapeutic agent etoposide (VP-16) has been used clinically in the treatment of lung cancer but possess different ...
Qi Dong, Chenkang Zhou, Haodong Ren, Zhijian Zhang, Feng Cheng, Zhenkai Xiong, Chuantao Chen, Jianke Yang, Jiguang Gao, Yao Zhang, Lei Xu, Jian Fang, Yuxiang Cao, Huijun Wei, Zhihao Wu   +14 more
doaj   +1 more source

Biochanin A inhibits lung adenocarcinoma progression by targeting ZEB1

Discover Oncology, 2022
Lung adenocarcinoma is the major subtype of lung cancer, accounting for approximately 40% of lung cancers. During clinical treatment, the emergence of chemotherapy resistance seriously affects the effectiveness of treatment.
Jianjun Li, Yaqi Kou, Xiaohan Zhang, Xuechun Xiao, Yang Ou, Lixia Cao, Min Guo, Chunchun Qi, Zhaoyang Wang, Yuxin Liu, Qiuying Shuai, Hang Wang, Shuang Yang   +12 more
doaj   +1 more source

The importance of the tumor microenvironment to understand tumor origin, evolution, and treatment response [PDF]

, 2022
During the second half of the twentieth century, oncology adopted a tumor-centric approach to cancer treatment, focusing primarily on the tumor cell to identify new therapeutic targets.
Ignacio Ochoa Garrido, Jose M. Ayuso, Ayuso, J. M., Ochoa Garrido, I.   +3 more
core   +1 more source

Effects of Exosomal Viral Components on the Tumor Microenvironment

, 2022
SIMPLE SUMMARY: Oncogenic viral infection may lead to cancers, such as nasopharyngeal carcinoma, hepatocellular carcinoma, and cervical cancer. In addition to the tumor cells themselves, the tumor microenvironment also plays a decisive role in tumor ...
Jing Li, Yan Zhang, Li, Jing, Bing Luo, Zhang, Yan, Luo, Bing   +5 more
core   +1 more source