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Cell Death Discovery, 2023 Ferroptosis is a newly defined non-apoptotic programmed cell death resulting from the accumulation of lipid peroxides. Whether ferroptosis plays any role in chemotherapy remains to be established.
Feng Cheng +8 more
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Medicina, 2019 Background and Objectives: The tumor microenvironment has been widely implicated in tumorigenesis because it harbors tumor cells that interact with surrounding cells through the circulatory and lymphatic systems to influence the development and progression of cancer.
Arneth, Borros +1 more
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Tumor microenvironment antigens [PDF]
Seminars in Immunopathology, 2022 AbstractThe identification and characterization of tumor antigens are central objectives in developing anti-cancer immunotherapy. Traditionally, tumor-associated antigens (TAAs) are considered relatively restricted to tumor cells (i.e., overexpressed proteins in tumor cells), whereas tumor-specific antigens (TSAs) are considered unique to tumor cells ...
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Indian Journal of Medical and Paediatric Oncology, 2020 A tumor is not simply a group of cancer cells, but rather a heterogeneous collection of infiltrating and resident host cells, secreted factors and extracellular matrix. Tumor cells stimulate significant molecular, cellular and physical changes within their host tissues to support tumor growth and progression.
Azgar Abdul Rasheed +1 more
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Journal of Immunology Research, 2023 Background. Tuberculosis (TB), caused by the bacterium Mycobacterium tuberculosis, affects approximately one-quarter of the global population and is considered one of the most lethal infectious diseases worldwide.
Shuai Ma +4 more
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KDM1A Identified as a Potential Oncogenic Driver and Prognostic Biomarker via Multi-Omics Analysis
Canadian Journal of Infectious Diseases and Medical Microbiology, 2021 Background. Lysine-specific demethylase 1A (KDM1A) is a histone demethylation enzyme and a crucial epigenetic factor for multiple pathological pathways that mediate carcinogenesis and immunogenicity.
Lingyue Li +4 more
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A human lung tumor microenvironment interactome identifies clinically relevant cell-type cross-talk. [PDF]
, 2020 BackgroundTumors comprise a complex microenvironment of interacting malignant and stromal cell types. Much of our understanding of the tumor microenvironment comes from in vitro studies isolating the interactions between malignant cells and a single ...
Azizi, Armon +19 more
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Cell Communication and Signaling, 2020 Background Metabolic reprogramming contributes significantly to tumor development and is tightly linked to drug resistance. The chemotherapeutic agent etoposide (VP-16) has been used clinically in the treatment of lung cancer but possess different ...
Qi Dong +14 more
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Biochanin A inhibits lung adenocarcinoma progression by targeting ZEB1
Discover Oncology, 2022 Lung adenocarcinoma is the major subtype of lung cancer, accounting for approximately 40% of lung cancers. During clinical treatment, the emergence of chemotherapy resistance seriously affects the effectiveness of treatment.
Jianjun Li +12 more
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Tumor microenvironment revisited [PDF]
EMBO reports, 2014 A number of authoritative reviews devoted to the role of the tumor microenvironment have been published in recent years [1], [2]. It is evident that the tumor stroma can modulate many tumor characteristics including the response to therapy. We need to keep this in mind, especially now that there is an increasing tendency to base intervention strategies
Anton, Berns, Pier Paolo, Pandolfi
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