Results 1 to 10 of about 1,857,357 (268)

Drug-induced lactate confers ferroptosis resistance via p38-SGK1-NEDD4L-dependent upregulation of GPX4 in NSCLC cells

Cell Death Discovery, 2023
Ferroptosis is a newly defined non-apoptotic programmed cell death resulting from the accumulation of lipid peroxides. Whether ferroptosis plays any role in chemotherapy remains to be established.
Feng Cheng, Jintao Dou, Yi Yang, Shaojie Sun, Ruiqi Chen, Zhijian Zhang, Huijun Wei, Jianhui Li, Zhihao Wu   +8 more
doaj   +1 more source

The importance of the tumor microenvironment to understand tumor origin, evolution, and treatment response [PDF]

, 2022
During the second half of the twentieth century, oncology adopted a tumor-centric approach to cancer treatment, focusing primarily on the tumor cell to identify new therapeutic targets.
Ignacio Ochoa Garrido, Jose M. Ayuso, Ayuso, J. M., Ochoa Garrido, I.   +3 more
core   +1 more source

Tumor Microenvironment as a Therapeutic Target in Melanoma Treatment [PDF]

, 2023
The role of the tumor microenvironment in tumor growth and therapy has recently attracted more attention in research and drug development. The ability of the microenvironment to trigger tumor maintenance, progression, and resistance is the main cause for
Thomas W. Flanagan, Kharouf, Naji, Hassan, Sofie-Yasmin, Khabaz, Marla, Marla Khabaz, Sofie-Yasmin Hassan, Flanagan, Thomas W., Hassan, Sarah-Lilly, Mosaad Megahed, Megahed, Mosaad, Sarah-Lilly Hassan, Hassan, Sofie Yasmin, Hassan, Mohamed, Hosam Shalaby, Simeon Santourlidis, Mohamed Hassan, Santourlidis, Simeon, Hassan, Sarah Lilly, Shalaby, Hosam, Naji Kharouf, Youssef Haikel, Haikel, Youssef   +21 more
core   +1 more source

Predicting the Progress of Tuberculosis by Inflammatory Response-Related Genes Based on Multiple Machine Learning Comprehensive Analysis

Journal of Immunology Research, 2023
Background. Tuberculosis (TB), caused by the bacterium Mycobacterium tuberculosis, affects approximately one-quarter of the global population and is considered one of the most lethal infectious diseases worldwide.
Shuai Ma, Peifei Peng, Zhihao Duan, Yifeng Fan, Xinzhi Li   +4 more
doaj   +1 more source

KDM1A Identified as a Potential Oncogenic Driver and Prognostic Biomarker via Multi-Omics Analysis

Canadian Journal of Infectious Diseases and Medical Microbiology, 2021
Background. Lysine-specific demethylase 1A (KDM1A) is a histone demethylation enzyme and a crucial epigenetic factor for multiple pathological pathways that mediate carcinogenesis and immunogenicity.
Lingyue Li, Yiyu Wang, Yuan Mou, Hao Wu, Ye Qin   +4 more
doaj   +1 more source

Lactate-induced MRP1 expression contributes to metabolism-based etoposide resistance in non-small cell lung cancer cells

Cell Communication and Signaling, 2020
Background Metabolic reprogramming contributes significantly to tumor development and is tightly linked to drug resistance. The chemotherapeutic agent etoposide (VP-16) has been used clinically in the treatment of lung cancer but possess different ...
Qi Dong, Chenkang Zhou, Haodong Ren, Zhijian Zhang, Feng Cheng, Zhenkai Xiong, Chuantao Chen, Jianke Yang, Jiguang Gao, Yao Zhang, Lei Xu, Jian Fang, Yuxiang Cao, Huijun Wei, Zhihao Wu   +14 more
doaj   +1 more source

Biochanin A inhibits lung adenocarcinoma progression by targeting ZEB1

Discover Oncology, 2022
Lung adenocarcinoma is the major subtype of lung cancer, accounting for approximately 40% of lung cancers. During clinical treatment, the emergence of chemotherapy resistance seriously affects the effectiveness of treatment.
Jianjun Li, Yaqi Kou, Xiaohan Zhang, Xuechun Xiao, Yang Ou, Lixia Cao, Min Guo, Chunchun Qi, Zhaoyang Wang, Yuxin Liu, Qiuying Shuai, Hang Wang, Shuang Yang   +12 more
doaj   +1 more source

Screening of Molecular Markers of Cisplatin Resistance in Lung Adenocarcinoma and Functional Verification Based on TCGA Database

Zhongliu Fangzhi Yanjiu, 2022
Objective To explore the related genes that play a key regulatory role in cisplatin resistance in lung adenocarcinoma. Methods Bioinformatics methods were used to download the differentially-expressed genes between cisplatin sensitive group and drug ...
WANG Lin, HUANG Zixian, YOU Chengcheng, TAN Shunzi, HUANG Liming, HUANG Yiling   +5 more
doaj   +1 more source

Targeting Tie2 in the Tumor Microenvironment: From Angiogenesis to Dissemination

, 2021
The Tie2 receptor tyrosine kinase is expressed in vascular endothelial cells, tumor-associated macrophages, and tumor cells and has been a major focus of research in therapies targeting the tumor microenvironment.
George S. Karagiannis, John S. Condeelis, David Entenberg, Lucia Borriello, Camille L. Duran, Maja H. Oktay   +5 more
core   +1 more source

Clinical Strategies Targeting the Tumor Microenvironment of Pancreatic Ductal Adenocarcinoma

, 2022
Pancreatic cancer has a complex tumor microenvironment which engages in extensive crosstalk between cancer cells, cancer-associated fibroblasts, and immune cells. Many of these interactions contribute to tumor resistance to anti-cancer therapies.
Christine Alewine, Samuel L. Ricci, Palestino Dominguez, Mayrel, Nebojsa Skorupan, Mayrel Palestino Dominguez, Alewine, Christine, Ricci, Samuel L., Skorupan, Nebojsa   +7 more
core   +1 more source