Results 1 to 10 of about 78,175 (168)
The Mechanism of Warburg Effect-Induced Chemoresistance in Cancer
Frontiers in Oncology, 2021 Although chemotherapy can improve the overall survival and prognosis of cancer patients, chemoresistance remains an obstacle due to the diversity, heterogeneity, and adaptability to environmental alters in clinic.
Fan Zhimin
exaly +3 more sources
Disease Models & Mechanisms, 2021 Extramedullary multiple myeloma (EMM) has an overall survival of 6 months and occurs in 20% of multiple myeloma (MM) patients. Genetic and epigenetic mechanisms involved in EMM and the therapeutic role of new agents for MM are not well established ...
Lourdes Farre +15 more
doaj +1 more source
Clinical and Translational Medicine, 2022 Background Although chemotherapy, the most widely used systemic treatment in triple‐negative breast cancer (TNBC), markedly improved the patients’ outcome, chemoresistance always occurs.
Zhenchong Xiong +7 more
doaj +1 more source
The MicroRNA-Based Strategies to Combat Cancer Chemoresistance via Regulating Autophagy
Frontiers in Oncology, 2022 Chemoresistance frequently occurs in cancer treatment, which results in chemotherapy failure and is one of the most leading causes of cancer-related death worldwide.
Yuhe Lei +5 more
doaj +1 more source
Antioxidants, 2023 Chemoresistance remains the foremost challenge in cancer therapy. Targeting reactive oxygen species (ROS) manipulation is a promising strategy in cancer treatment since tumor cells present high levels of intracellular ROS, which makes them more ...
Huan Wang +5 more
doaj +1 more source
Clusterin and Chemoresistance [PDF]
, 2009 Resistance to anticancer agents is one of the primary impediments to effective cancer therapy. Chemoresistance occurs not only to clinically established therapeutic agents but also to novel targeted therapeutics. Both intrinsic and acquired mechanisms have been implicated in drug resistance but it remains controversial which mechanisms are responsible ...
Julie Y, Djeu, Sheng, Wei
openaire +2 more sources
Mitochondrial determinants of chemoresistance [PDF]
Cancer Drug Resistance, 2019 Chemoresistance constitute nowadays the major contributor to therapy failure in most cancers. There are main factors that mitigate cell response to therapy, such as target organ, inherent sensitivity to the administered compound, its metabolism, drug efflux and influx or alterations on specific cellular targets, among others. We now know that intrinsic
Bokil, Ansooya, Sancho, Patricia
openaire +2 more sources
Apoptosis and melanoma chemoresistance [PDF]
Oncogene, 2003 Melanoma is the most aggressive form of skin cancer and is notoriously resistant to all current modalities of cancer therapy. A large set of genetic, functional and biochemical studies suggest that melanoma cells become 'bullet proof' against a variety of chemotherapeutic drugs by exploiting their intrinsic resistance to apoptosis and by reprogramming ...
María S, Soengas, Scott W, Lowe
openaire +2 more sources
AKAP8L enhances the stemness and chemoresistance of gastric cancer cells by stabilizing SCD1 mRNA
Cell Death and Disease, 2022 Gastric cancer (GC) remains the third leading cause of cancer-related deaths. Chemoresistance is the major determinant of GC treatment failure. To explore the molecular mechanisms of GC chemoresistance, mass spectrometry was performed to detect the genes
Ruihong Zhang +10 more
doaj +1 more source
Identification of multidrug chemoresistant genes in head and neck squamous cell carcinoma cells
Molecular Cancer, 2023 Multidrug resistance renders treatment failure in a large proportion of head and neck squamous cell carcinoma (HNSCC) patients that require multimodal therapy involving chemotherapy in conjunction with surgery and/or radiotherapy.
Neha Khera +6 more
doaj +1 more source