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Molecular Bases of Chemoresistance in Cholangiocarcinoma
Current Drug Targets, 2017The multidrug resistance (MDR) phenotype accounts for the poor response of cholangiocarcinoma to available antitumor drugs. This is an important limitation to the use of pharmacological approaches, both as adjuvant therapies and for treating advanced CCA when surgical removal is not possible.
Jose J G, Marin +5 more
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Isolation of Chemoresistant Cell Subpopulations
2016Chemoresistance is a major challenge for cancer therapy and drives tumor relapse. The emergence, within the treated tumor mass, of specific cancer cell subpopulations endowed with high tolerance to the microenvironment stress induced by therapy is being growingly recognized as a mechanism of tumor progression. To obtain detailed information with regard
Claudia, Canino, Mario, Cioce
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A snapshot of chemoresistance to PARP inhibitors
Trends in Pharmacological Sciences, 2012The exploitation of synthetic lethality in BRCA-deficient tumor carriers using potent inhibitors of the enzyme poly(ADP-ribose) polymerase (PARP)-1 has led to an enthusiastic response among basic scientists, oncologists and pharmaceutical companies. However, accumulating evidence demonstrates that resistance to these drugs develops in tumors in both ...
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A short update on cancer chemoresistance
Wiener Medizinische Wochenschrift, 2014Chemotherapeutic interventions in cancer patients are limited by the appearance of chemoresistance. For instance, advanced lung and ovarian cancer patients relapse invariably after few cycles of platinum-based chemotherapy. Disseminated tumors are characterized by genetic instability/heterogeneity, thus containing or generating a repertoire of ...
Gerhard, Hamilton, Barbara, Rath
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Battling Chemoresistance in Cancer: Root Causes and Strategies to Uproot Them
International Journal of Molecular Sciences, 2021Hossein Tabatabaeian +2 more
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Tunneling Nanotubes: Implications for Chemoresistance
Tunneling nanotubes (TNTs) are thin, membranous protrusions that connect cells and allow for the transfer of various molecules, including proteins, organelles, and genetic material. TNTs have been implicated in a wide range of biological processes, including intercellular communication, drug resistance, and viral transmission. In cancer, they have beenSanyukta, Padmanabhan +3 more
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CHD4 promotes acquired chemoresistance and tumor progression by activating the MEK/ERK axis
Drug Resistance Updates, 2023Zhu Shiyu
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Emerging role of NRF2 in ROS-mediated tumor chemoresistance
Biomedicine and Pharmacotherapy, 2020Jiaxuan Qiu, Danfeng Xue
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