Results 1 to 10 of about 81,797 (118)
The Mechanism of Warburg Effect-Induced Chemoresistance in Cancer
Frontiers in Oncology, 2021 Although chemotherapy can improve the overall survival and prognosis of cancer patients, chemoresistance remains an obstacle due to the diversity, heterogeneity, and adaptability to environmental alters in clinic.
Chang Liu, Ying Jin, Zhimin Fan
exaly +3 more sources
LncRNA FAM66C enhances gastric cancer proliferation and chemoresistance through phosphorylating nuclear YAP protein [PDF]
Frontiers in PharmacologyBackgroundChemoresistance is one of the causes of death in patients with gastric cancer (GC). Extensive studies have demonstrated that lncRNAs have important implications in GC chemoresistance, but their underlying mechanisms in driving GC ...
Chao Yang +5 more
doaj +2 more sources
Disease Models & Mechanisms, 2021 Extramedullary multiple myeloma (EMM) has an overall survival of 6 months and occurs in 20% of multiple myeloma (MM) patients. Genetic and epigenetic mechanisms involved in EMM and the therapeutic role of new agents for MM are not well established ...
Lourdes Farre +15 more
doaj +1 more source
The MicroRNA-Based Strategies to Combat Cancer Chemoresistance via Regulating Autophagy
Frontiers in Oncology, 2022 Chemoresistance frequently occurs in cancer treatment, which results in chemotherapy failure and is one of the most leading causes of cancer-related death worldwide.
Yuhe Lei +5 more
doaj +1 more source
Clinical and Translational Medicine, 2022 Background Although chemotherapy, the most widely used systemic treatment in triple‐negative breast cancer (TNBC), markedly improved the patients’ outcome, chemoresistance always occurs.
Zhenchong Xiong +7 more
doaj +1 more source
Antioxidants, 2023 Chemoresistance remains the foremost challenge in cancer therapy. Targeting reactive oxygen species (ROS) manipulation is a promising strategy in cancer treatment since tumor cells present high levels of intracellular ROS, which makes them more ...
Huan Wang +5 more
doaj +1 more source
AKAP8L enhances the stemness and chemoresistance of gastric cancer cells by stabilizing SCD1 mRNA
Cell Death and Disease, 2022 Gastric cancer (GC) remains the third leading cause of cancer-related deaths. Chemoresistance is the major determinant of GC treatment failure. To explore the molecular mechanisms of GC chemoresistance, mass spectrometry was performed to detect the genes
Ruihong Zhang +10 more
doaj +1 more source
Journal of Extracellular Vesicles, 2023 Ovarian cancer (OvCa) is the gynaecological disorder with the poorest prognosis due to the fast development of chemoresistance. We sought to connect chemoresistance and cancer cell‐derived extracellular vesicles (EV).
Gerrit Hugendieck +16 more
doaj +1 more source
Materials & Design, 2021 Chemoresistance remains a huge challenge for the treatment of osteosarcoma (OS). Multiple mechanisms are involved in chemoresistance of cisplatin.
Chong Zhang +6 more
doaj +1 more source
Identification of multidrug chemoresistant genes in head and neck squamous cell carcinoma cells
Molecular Cancer, 2023 Multidrug resistance renders treatment failure in a large proportion of head and neck squamous cell carcinoma (HNSCC) patients that require multimodal therapy involving chemotherapy in conjunction with surgery and/or radiotherapy.
Neha Khera +6 more
doaj +1 more source