Results 21 to 30 of about 99,790 (252)

Emerging Significance of Ginsenosides as Potentially Reversal Agents of Chemoresistance in Cancer Therapy

Frontiers in Pharmacology, 2021
Chemoresistance has become a prevalent phenomenon in cancer therapy, which alleviates the effect of chemotherapy and makes it difficult to break the bottleneck of the survival rate of tumor patients.
Jin-Feng Xu, Yan Wan, Fei Tang, Lu Chen, Yu Yang, Jia Xia, Jiao-Jiao Wu, Hui Ao, Hui Ao, Cheng Peng   +9 more
doaj   +1 more source

Identification of key genes and pathways related to cancer-associated fibroblasts in chemoresistance of ovarian cancer cells based on GEO and TCGA databases

Journal of Ovarian Research, 2022
Background Studies have revealed the implications of cancer-associated fibroblasts (CAFs) in tumor progression, metastasis, and treatment resistance.
Li Han, Xiaojuan Guo, Ruijuan Du, Kelei Guo, Pei Qi, Hua Bian   +5 more
doaj   +1 more source

The Emerging Role of Exosomes in Cancer Chemoresistance

Frontiers in Cell and Developmental Biology, 2021
Chemoresistance is an impending challenge in cancer treatment. In recent years, exosomes, a subtype of extracellular vesicles with a diameter of 40–150 nm in bloodstream and other bio-fluids, have attracted increasing interest. Exosomes contain proteins,
Jing Li, Na Gao, Zhengfan Gao, Wei Liu, Bairen Pang, Xingli Dong, Yong Li, Yong Li, Tianli Fan   +8 more
doaj   +1 more source

DNA methylation characteristics associated with chemotherapy resistance in epithelial ovarian cancer

Heliyon
Objective: The high mortality rate of epithelial ovarian cancer (EOC) is often attributed to the frequent development of chemoresistance. DNA methylation is a predictive biomarker for chemoresistance. Methods: This study utilized DNA methylation profiles
Changling Duan, Zhongxin Yan, Cailiang Wu, Xuexin Zhou, Wei Bao   +4 more
doaj   +1 more source

Antioxidant and Anticancer Activity of Vitis vinifera Extracts in Breast Cell Lines

Life
Vitis vinifera extracts have been shown to possess antioxidant activity because of their polyphenol content. In addition, their therapeutic potential against several diseases, including cancer, has been reported.
Evgenia Maria Tsantila, Nils Esslinger, Maria Christou, Panagiotis Papageorgis, Christiana M. Neophytou   +4 more
doaj   +1 more source

Cytoplasmic translocation of p21 mediates NUPR1-induced chemoresistance NUPR1 and p21 in chemoresistance [PDF]

, 2012
The expression of Nuclear Protein 1 (NUPR1) is associated with chemoresistance in multiple malignancies. We previously reported that NUPR1 functions as a transcriptional cofactor for the p300–p53 complex and transcriptionally regulates p21 expression. In
Samant, Rajeev S., Rajeev S. Samant, Lalita A. Shevde, Ren, Suping, Devine, Daniel J., Daniel J. Devine, Andrew J. Vincent, Harris, Lillianne G., Shevde, Lalita A., Suping Ren, Fodstad, Oystein, Vincent, Andrew J., Lillianne G. Harris, Oystein Fodstad   +13 more
core   +1 more source

The histological growth patterns in liver metastases from colorectal cancer display differences in lymphoid, myeloid, and mesenchymal cells

MedComm
Colorectal liver metastases grow following different histologic growth patterns (HGPs), classified as desmoplastic and nondesmoplastic (dHGP, non‐dHGP), being the latter associated with worst prognosis.
Gemma Garcia‐Vicién, Núria Ruiz, Patrick Micke, José Carlos Ruffinelli, Kristel Mils, María Bañuls, Natalia Molina, Miguel A. Pardo, Laura Lladó, Artur Mezheyeuski, David G. Molleví   +10 more
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

Long noncoding RNA GSTM3TV2 upregulates LAT2 and OLR1 by competitively sponging let-7 to promote gemcitabine resistance in pancreatic cancer

Journal of Hematology & Oncology, 2019
Background Chemoresistance is one of the main causes of poor prognosis in pancreatic cancer patients. Understanding the mechanisms implicated in chemoresistance of pancreatic cancer is critical to improving patient outcomes.
Guangbing Xiong, Chang Liu, Gang Yang, Mengyu Feng, Jianwei Xu, Fangyu Zhao, Lei You, Li Zhou, Lianfang Zheng, Ya Hu, Xiaowo Wang, Taiping Zhang, Yupei Zhao   +12 more
doaj   +1 more source