Results 21 to 30 of about 78,175 (168)

Mitochondria and cancer chemoresistance

Biochimica et Biophysica Acta (BBA) - Bioenergetics, 2017
Mitochondria, known for more than a century as the energy powerhouse of a cell, represent key intracellular signaling hub that are emerging as important determinants of several aspects of cancer development and progression, including metabolic reprogramming, acquisition of metastatic capability, and response to chemotherapeutic drugs.
Guerra F., Arbini A. A., Moro L.
openaire   +3 more sources

Early Mechanisms of Chemoresistance in Retinoblastoma

Cancers, 2022
Retinoblastoma is the most common eye cancer in children and is fatal if left untreated. Over the past three decades, chemotherapy has become the mainstay of eye-sparing treatment. Nevertheless, chemoresistance continues to represent a major challenge leading to ocular and systemic toxicity, vision loss, and treatment failure.
Michelle G. Zhang, Jeffim N. Kuznetsoff, Dawn A. Owens, Ryan A. Gallo, Karthik Kalahasty, Anthony M. Cruz, Stefan Kurtenbach, Zelia M. Correa, Daniel Pelaez, J. William Harbour   +9 more
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Chemoresistance in solid tumours

Annals of Oncology, 2006
Drug resistance is a major factor that limits the effectiveness ofchemotherapy. Tumours can be intrinsically resistant prior tochemotherapy, or resistance may be acquired during treatmentby tumours that are initially sensitive to chemotherapy [1].Furthermore, in the process of acquiring resistance, the tumourmay become cross-resistant to a range of ...
T R, Wilson, D B, Longley, P G, Johnston
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DNA methylation characteristics associated with chemotherapy resistance in epithelial ovarian cancer

Heliyon
Objective: The high mortality rate of epithelial ovarian cancer (EOC) is often attributed to the frequent development of chemoresistance. DNA methylation is a predictive biomarker for chemoresistance. Methods: This study utilized DNA methylation profiles
Changling Duan, Zhongxin Yan, Cailiang Wu, Xuexin Zhou, Wei Bao   +4 more
doaj   +1 more source

The Emerging Role of Exosomes in Cancer Chemoresistance

Frontiers in Cell and Developmental Biology, 2021
Chemoresistance is an impending challenge in cancer treatment. In recent years, exosomes, a subtype of extracellular vesicles with a diameter of 40–150 nm in bloodstream and other bio-fluids, have attracted increasing interest. Exosomes contain proteins,
Jing Li, Na Gao, Zhengfan Gao, Wei Liu, Bairen Pang, Xingli Dong, Yong Li, Yong Li, Tianli Fan   +8 more
doaj   +1 more source

Antioxidant and Anticancer Activity of Vitis vinifera Extracts in Breast Cell Lines

Life
Vitis vinifera extracts have been shown to possess antioxidant activity because of their polyphenol content. In addition, their therapeutic potential against several diseases, including cancer, has been reported.
Evgenia Maria Tsantila, Nils Esslinger, Maria Christou, Panagiotis Papageorgis, Christiana M. Neophytou   +4 more
doaj   +1 more source

Long noncoding RNA GSTM3TV2 upregulates LAT2 and OLR1 by competitively sponging let-7 to promote gemcitabine resistance in pancreatic cancer

Journal of Hematology & Oncology, 2019
Background Chemoresistance is one of the main causes of poor prognosis in pancreatic cancer patients. Understanding the mechanisms implicated in chemoresistance of pancreatic cancer is critical to improving patient outcomes.
Guangbing Xiong, Chang Liu, Gang Yang, Mengyu Feng, Jianwei Xu, Fangyu Zhao, Lei You, Li Zhou, Lianfang Zheng, Ya Hu, Xiaowo Wang, Taiping Zhang, Yupei Zhao   +12 more
doaj   +1 more source

The histological growth patterns in liver metastases from colorectal cancer display differences in lymphoid, myeloid, and mesenchymal cells

MedComm
Colorectal liver metastases grow following different histologic growth patterns (HGPs), classified as desmoplastic and nondesmoplastic (dHGP, non‐dHGP), being the latter associated with worst prognosis.
Gemma Garcia‐Vicién, Núria Ruiz, Patrick Micke, José Carlos Ruffinelli, Kristel Mils, María Bañuls, Natalia Molina, Miguel A. Pardo, Laura Lladó, Artur Mezheyeuski, David G. Molleví   +10 more
doaj   +1 more source

Exosomes in the Chemoresistance of Glioma: Key Point in Chemoresistance

Journal of Cellular and Molecular Medicine
ABSTRACTGliomas are the most ordinary primary virulent brain tumours and commonly used clinical treatments include tumour resection, radiation therapy and chemotherapy. Although significant progress has been made in recent years in progression‐free survival (PFS) and overall survival (OS) for patients with high‐grade gliomas, the prognosis for patients
Xu Guo, Haozhe Piao, Rui Sui
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OverAKT3: tumor progression and chemoresistance [PDF]

Cell Cycle, 2015
Akt3 is one of 3 closely related serine/threonine-protein kinases in the Akt family (Akt1, Akt2, and Akt3). Akt is among the most hyperactivated oncogenes in human cancer, regulating key cellular functions such as growth, proliferation, migration, invasion, angiogenesis, metabolism, and survival.1,2 Studies evaluating the effect of Akt isoform gene ...
Ping, Ji, Kristen M, Turner, Wei, Zhang
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