Redox control of multidrug resistance and Its possible modulation by antioxidants [PDF]
, 2016 Clinical efficacy of anticancer chemotherapies is dramatically hampered by multidrug resistance (MDR) dependent on inherited traits, acquired defence against toxins, and adaptive mechanisms mounting in tumours.
Cort, A. +4 more
core +3 more sources
Identification of multidrug chemoresistant genes in head and neck squamous cell carcinoma cells
Molecular Cancer, 2023 Multidrug resistance renders treatment failure in a large proportion of head and neck squamous cell carcinoma (HNSCC) patients that require multimodal therapy involving chemotherapy in conjunction with surgery and/or radiotherapy.
Neha Khera +6 more
doaj +1 more source
PAX2 regulates ADAM10 expression and mediates anchorage-independent cell growth of melanoma cells [PDF]
, 2011 PAX transcription factors play an important role during development and carcinogenesis. In this study, we investigated PAX2 protein levels in melanocytes and melanoma cells by Western Blot and immunofluorescence analysis and characterized the role of ...
Lee, Sophia Boyoung +11 more
core +8 more sources
Mitochondria and cancer chemoresistance
Biochimica et Biophysica Acta (BBA) - Bioenergetics, 2017 Mitochondria, known for more than a century as the energy powerhouse of a cell, represent key intracellular signaling hub that are emerging as important determinants of several aspects of cancer development and progression, including metabolic reprogramming, acquisition of metastatic capability, and response to chemotherapeutic drugs.
Guerra F., Arbini A. A., Moro L.
openaire +3 more sources
Capsaicin triggers autophagic cell survival which drives epithelial mesenchymal transition and chemoresistance in bladder cancer cells in an Hedgehog-dependent manner [PDF]
, 2016 Bladder cancer (BC) is a common urologic tumor characterized by high risk of recurrence and mortality. Capsaicin (CPS), used as an intravesical drug for overactive bladder, was demonstrated to induce cell death in different cancer cells including BC ...
Amantini, C +6 more
core +1 more source
Chemoresistance in solid tumours
Annals of Oncology, 2006 Drug resistance is a major factor that limits the effectiveness ofchemotherapy. Tumours can be intrinsically resistant prior tochemotherapy, or resistance may be acquired during treatmentby tumours that are initially sensitive to chemotherapy [1].Furthermore, in the process of acquiring resistance, the tumourmay become cross-resistant to a range of ...
T R, Wilson, D B, Longley, P G, Johnston
openaire +3 more sources
Predicting and Overcoming Taxane Chemoresistance [PDF]
Trends in Molecular Medicine, 2021 Taxanes are microtubule-targeting drugs used as cytotoxic chemotherapy to treat most solid tumors. The development of resistance to taxanes is a major cause of therapeutic failure and overcoming chemoresistance remains an important challenge to improve patient's outcome.
Rodrigues-Ferreira, Sylvie +3 more
openaire +2 more sources
p53 Signaling on Microenvironment and Its Contribution to Tissue Chemoresistance
Membranes, 2022 Chemoresistance persists as a significant, unresolved clinical challenge in many cancer types. The tumor microenvironment, in which cancer cells reside and interact with non-cancer cells and tissue structures, has a known role in promoting every aspect ...
Leonel Cardozo de Menezes e Souza +4 more
doaj +1 more source
Transforming Growth Factor Alpha Stimulation of Mucosal Tissue Cultures from Head and Neck Squamous Cell Carcinoma Patients Increases Chemoresistance to Cisplatin [PDF]
, 2010 The monoclonal epidermal growth factor receptor ( EGFR) antibody cetuximab (Erbitux(TM)) was recently approved by the European Medicines Agency for the treatment of recurrent and/or metastatic head and neck squamous cell carcinoma (HNSCC) in combination ...
Baumeister, Philipp +3 more
core +1 more source
Super-enhancers: a new frontier for epigenetic modifiers in cancer chemoresistance
Journal of Experimental & Clinical Cancer Research, 2021 Although new developments of surgery, chemotherapy, radiotherapy, and immunotherapy treatments for cancer have improved patient survival, the emergence of chemoresistance in cancer has significant impacts on treatment effects.
Guo-Hua Li +7 more
doaj +1 more source