Results 11 to 20 of about 78,175 (168)
Materials & Design, 2021 Chemoresistance remains a huge challenge for the treatment of osteosarcoma (OS). Multiple mechanisms are involved in chemoresistance of cisplatin.
Chong Zhang +6 more
doaj +1 more source
Journal of Extracellular Vesicles, 2023 Ovarian cancer (OvCa) is the gynaecological disorder with the poorest prognosis due to the fast development of chemoresistance. We sought to connect chemoresistance and cancer cell‐derived extracellular vesicles (EV).
Gerrit Hugendieck +16 more
doaj +1 more source
Predicting and Overcoming Taxane Chemoresistance [PDF]
Trends in Molecular Medicine, 2021 Taxanes are microtubule-targeting drugs used as cytotoxic chemotherapy to treat most solid tumors. The development of resistance to taxanes is a major cause of therapeutic failure and overcoming chemoresistance remains an important challenge to improve patient's outcome.
Rodrigues-Ferreira, Sylvie +3 more
openaire +2 more sources
p53 Signaling on Microenvironment and Its Contribution to Tissue Chemoresistance
Membranes, 2022 Chemoresistance persists as a significant, unresolved clinical challenge in many cancer types. The tumor microenvironment, in which cancer cells reside and interact with non-cancer cells and tissue structures, has a known role in promoting every aspect ...
Leonel Cardozo de Menezes e Souza +4 more
doaj +1 more source
Super-enhancers: a new frontier for epigenetic modifiers in cancer chemoresistance
Journal of Experimental & Clinical Cancer Research, 2021 Although new developments of surgery, chemotherapy, radiotherapy, and immunotherapy treatments for cancer have improved patient survival, the emergence of chemoresistance in cancer has significant impacts on treatment effects.
Guo-Hua Li +7 more
doaj +1 more source
Frontiers in Pharmacology, 2021 Chemoresistance has become a prevalent phenomenon in cancer therapy, which alleviates the effect of chemotherapy and makes it difficult to break the bottleneck of the survival rate of tumor patients.
Jin-Feng Xu +9 more
doaj +1 more source
Chemoresistance and chemosensitization in cholangiocarcinoma
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 2018 One of the main difficulties in the management of patients with advanced cholangiocarcinoma (CCA) is their poor response to available chemotherapy. This is the result of powerful mechanisms of chemoresistance (MOC) of quite diverse nature that usually act synergistically.
Marin, Jose J. G. +9 more
openaire +3 more sources
Exploring role of 5hmC as potential marker of chemoresistance
Molecular & Cellular Oncology, 2020 Chemoresistance remains to be a common and significant hurdle with all chemotherapies. Tumors gain resistance by acquiring additional mutations. Some of the chemoresistance mechanisms are known and can be tackled. However, the majority of chemoresistance
Suhas S. Kharat, Shyam K. Sharan
doaj +1 more source
Journal of Ovarian Research, 2022 Background Studies have revealed the implications of cancer-associated fibroblasts (CAFs) in tumor progression, metastasis, and treatment resistance.
Li Han +5 more
doaj +1 more source
Role of SIRT1 in Chemoresistant Leukemia
International Journal of Molecular Sciences, 2023 Leukemias of the AML, CML, and CLL types are the most common blood cancers worldwide, making them a major global public health problem. Furthermore, less than 24% of patients treated with conventional chemotherapy (low-risk patients) and 10–15% of patients ineligible for conventional chemotherapy (high-risk patients) survive five years.
Guadalupe Rosario Fajardo-Orduña +4 more
openaire +2 more sources