Results 11 to 20 of about 136,885 (362)
Controlling secretion to limit chemoresistance [PDF]
Genes & Development, 2016 The tumor microenvironment influences cancer progression and therapy outcome by mechanisms not yet fully understood. In this issue, Bent et al. (2016) show how chemotherapy causes endothelial senescence.
Georgilis, A, Gil, J
core +6 more sources
KLF4 in cancer chemoresistance: molecular mechanisms and therapeutic implications [PDF]
Discover OncologyChemoresistance is a major obstacle in cancer treatment, and it often results in treatment failure and disease progression. Among the plethora of factors contributing to chemoresistance, the transcription factor Krüppel-like factor 4 (KLF4) has emerged ...
Suresh Singh Yadav +6 more
doaj +2 more sources
Mitochondrial determinants of chemoresistance [PDF]
Cancer Drug Resistance, 2019 Chemoresistance constitute nowadays the major contributor to therapy failure in most cancers. There are main factors that mitigate cell response to therapy, such as target organ, inherent sensitivity to the administered compound, its metabolism, drug efflux and influx or alterations on specific cellular targets, among others. We now know that intrinsic
Bokil, Ansooya, Sancho, Patricia
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Exosomal miR-331 from Chemoresistant Osteosarcoma Cells induced Chemoresistance through Autophagy [PDF]
, 2021 Abstract BackgroundOsteosarcoma (OS) is a highly malignant tumor. Improving chemotherapeutic resistance is very important to improve the survival rate of OS. Exosomes and microRNAs (MiRNA) play important roles in the mechanism of chemotherapeutic resistance transmission. More and more researches focus the mechanism of miRNAs carried by exosomes
Aiqing Zhao +8 more
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Clusterin and Chemoresistance [PDF]
, 2009 Resistance to anticancer agents is one of the primary impediments to effective cancer therapy. Chemoresistance occurs not only to clinically established therapeutic agents but also to novel targeted therapeutics. Both intrinsic and acquired mechanisms have been implicated in drug resistance but it remains controversial which mechanisms are responsible ...
Julie Y, Djeu, Sheng, Wei
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Apoptosis and melanoma chemoresistance [PDF]
Oncogene, 2003 Melanoma is the most aggressive form of skin cancer and is notoriously resistant to all current modalities of cancer therapy. A large set of genetic, functional and biochemical studies suggest that melanoma cells become 'bullet proof' against a variety of chemotherapeutic drugs by exploiting their intrinsic resistance to apoptosis and by reprogramming ...
María S, Soengas, Scott W, Lowe
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Chemoresistance in Pancreatic Cancer [PDF]
International Journal of Molecular Sciences, 2019 Pancreatic ductal adenocarcinoma (PDAC), generally known as pancreatic cancer (PC), ranks the fourth leading cause of cancer-related deaths in the western world. While the incidence of pancreatic cancer is displaying a rising tendency every year, the mortality rate has not decreased significantly because of late diagnosis, early metastasis, and limited
Siyuan Zeng +5 more
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Materials & Design, 2021 Chemoresistance remains a huge challenge for the treatment of osteosarcoma (OS). Multiple mechanisms are involved in chemoresistance of cisplatin.
Chong Zhang +6 more
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Endoglin Is Essential for the Maintenance of Self-Renewal and Chemoresistance in Renal Cancer Stem Cells. [PDF]
, 2017 Renal cell carcinoma (RCC) is a deadly malignancy due to its tendency to metastasize and resistance to chemotherapy. Stem-like tumor cells often confer these aggressive behaviors.
Dai, Jin +10 more
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Journal of Extracellular Vesicles, 2023 Ovarian cancer (OvCa) is the gynaecological disorder with the poorest prognosis due to the fast development of chemoresistance. We sought to connect chemoresistance and cancer cell‐derived extracellular vesicles (EV).
Gerrit Hugendieck +16 more
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