p53 Signaling on Microenvironment and Its Contribution to Tissue Chemoresistance
Membranes, 2022 Chemoresistance persists as a significant, unresolved clinical challenge in many cancer types. The tumor microenvironment, in which cancer cells reside and interact with non-cancer cells and tissue structures, has a known role in promoting every aspect ...
Leonel Cardozo de Menezes e Souza +4 more
doaj +2 more sources
Exploring role of 5hmC as potential marker of chemoresistance
Molecular & Cellular Oncology, 2020 Chemoresistance remains to be a common and significant hurdle with all chemotherapies. Tumors gain resistance by acquiring additional mutations. Some of the chemoresistance mechanisms are known and can be tackled. However, the majority of chemoresistance
Suhas S. Kharat, Shyam K. Sharan
doaj +2 more sources
O-GlcNAcylation Regulation of SNAP29-Dependent Autophagy Activation Dictates Chemoresistance in Gastric Cancer. [PDF]
Adv Sci (Weinh)Model illustrating the proposed mechanism by which chemotherapy‐induced downregulation of OGT disrupts SNAP29 O‐GlcNAcylation, promoting STX17‐SNAP29‐VAMP8 SNARE complex assembly and protective autophagy, leading to chemoresistance, which in turn establishes a feedforward loop to perpetuate drug tolerance.
Tang L +9 more
europepmc +2 more sources
Overcoming chemoresistance via extracellular vesicle inhibition [PDF]
, 2021 With the ever-growing number of cancer deaths worldwide, researchers have been working hard to identify the key reasons behind the failure of cancer therapies so the efficacy of those therapies may be improved.
Fong, Zhijack +5 more
core +1 more source
Chemoresistance acquisition induces a global shift of expression of aniogenesis-associated genes and increased pro-angogenic activity in neuroblastoma cells [PDF]
, 2009 BACKGROUND: Chemoresistance acquisition may influence cancer cell biology. Here, bioinformatics analysis of gene expression data was used to identify chemoresistance-associated changes in neuroblastoma biology.
Tatyana Suhan +50 more
core +16 more sources
Combating the Epigenome: Elucidation of Mechanisms Underlying Chemoresistance and Enhancing Tumor Immunogenicity [PDF]
, 2017 Chemotherapy and radiation therapy remain the backbone of cancer treatments, and now cancer immunotherapy offers promising new approaches for the treatment of malignancies. One of the major obstacles for chemo-based therapies is acquired chemoresistance.
Cacan, Ercan
core +1 more source
An FBXW7-ZEB2 axis links EMT and tumour microenvironment to promote colorectal cancer stem cells and chemoresistance [PDF]
, 2019 Colorectal cancer (CRC) patients develop recurrence after chemotherapy owing to the survival of stem cell-like cells referred to as cancer stem-like cells (CSCs).
Clevers, Hans +16 more
core +1 more source
The role of miRNAs in the diagnosis, chemoresistance, and prognosis of pancreatic ductal adenocarcinoma [PDF]
, 2018 Le Ren, Yue Yu Department of Gastroenterology, Affiliated Provincial Hospital, Anhui Medical University, Hefei, China Abstract: Pancreatic ductal adenocarcinoma (PDAC) remains a very challenging malignancy with late presentation, metastatic potential ...
Ren L, Le Ren, Yue Yu, Yu Y
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miR-200c sensitizes breast cancer cells to doxorubicin treatment by decreasing TrkB and Bmi1 expression. [PDF]
, 2012 Acquired resistance to classical chemotherapeutics is a major obstacle in cancer treatment. Doxorubicin is frequently used in breast cancer therapy either as single-agent or in combination with other drugs like docetaxel and cyclophosphamide.
Oak, Prajakta S. +11 more
core +2 more sources
Super-enhancers: a new frontier for epigenetic modifiers in cancer chemoresistance
Journal of Experimental & Clinical Cancer Research, 2021 Although new developments of surgery, chemotherapy, radiotherapy, and immunotherapy treatments for cancer have improved patient survival, the emergence of chemoresistance in cancer has significant impacts on treatment effects.
Guo-Hua Li +7 more
doaj +1 more source