Results 1 to 10 of about 3,346,248 (200)

TEM1-targeting PEGylated PLGA shikonin nanoformulation for immunomodulation and eradication of ovarian cancer [PDF]

BioImpacts, 2022
Introduction: Tumor endothelial marker 1 (TEM1) is expressed by tumor vascular endothelial cells in various cancers. Methods: Here, we developed poly(lactic-co-glycolic acid) (PLGA) nanoparticles (NPs) PEGylated with polyethylene glycol (PEG) and ...
Efthymia-Iliana Matthaiou, Yi Guo, Jaleh Barar, Raphael Sandaltzopoulos, Lana E. Kandalaft, Chunsheng Li, George Coukos, Yadollah Omidi   +7 more
doaj   +1 more source

Loss of LKB1-NUAK1 signalling enhances NF-κB activity in a spheroid model of high-grade serous ovarian cancer

Scientific Reports, 2022
High-grade serous ovarian cancer (HGSOC) is an aggressive malignancy often diagnosed at an advanced stage. Although most HGSOC patients respond initially to debulking surgery combined with cytotoxic chemotherapy, many ultimately relapse with platinum ...
Adrian Buensuceso, Jamie Lee Fritz, Olga Collins, Yudith Ramos Valdés, Matthew J. Borrelli, Gabriel E. DiMattia, Trevor G. Shepherd   +6 more
doaj   +1 more source

Overlapping gene dependencies for PARP inhibitors and carboplatin response identified by functional CRISPR-Cas9 screening in ovarian cancer

Cell Death and Disease, 2022
PARP inhibitors (PARPi) have revolutionized the therapeutic landscape of epithelial ovarian cancer (EOC) treatment with outstanding benefits in regard to progression-free survival, especially in patients either carrying BRCA1/2 mutations or harboring ...
Ricardo Coelho, Alessandra Tozzi, Muriel Disler, Flavio Lombardo, André Fedier, Mónica Núñez López, Florian Freuler, Francis Jacob, Viola Heinzelmann-Schwarz   +8 more
doaj   +1 more source

Gain-of-function p53R175H blocks apoptosis in a precursor model of ovarian high-grade serous carcinoma

Scientific Reports, 2023
Ovarian high-grade serous carcinoma (HGSC) is a highly lethal malignancy for which early detection is a challenge and treatment of late-stage disease is ineffective. HGSC initiation involves exfoliation of fallopian tube epithelial (FTE) cells which form
Jacob Haagsma, Bart Kolendowski, Adrian Buensuceso, Yudith Ramos Valdes, Gabriel E. DiMattia, Trevor G. Shepherd   +5 more
doaj   +1 more source

Activated CAMKKβ-AMPK signaling promotes autophagy in a spheroid model of ovarian tumour metastasis

Journal of Ovarian Research, 2020
Background A hallmark of epithelial ovarian cancer (EOC) metastasis is the process of spheroid formation, whereby tumour cells aggregate into 3D structures while in suspension in the peritoneal cavity.
Jeremi Laski, Bipradeb Singha, Xu Wang, Yudith Ramos Valdés, Olga Collins, Trevor G. Shepherd   +5 more
doaj   +1 more source

L1CAM is required for early dissemination of fallopian tube carcinoma precursors to the ovary

Communications Biology, 2022
L1CAM is implicated as an important factor that enables early fallopian tube cancer precursors to seed the ovary by promoting cell survival through extracellular matrix signaling, thereby facilitating ovarian cancer growth.
Kai Doberstein, Rebecca Spivak, Hunter D. Reavis, Jagmohan Hooda, Yi Feng, Paul T. Kroeger, Sarah Stuckelberger, Gordon B. Mills, Kyle M. Devins, Lauren E. Schwartz, Marcin P. Iwanicki, Mina Fogel, Peter Altevogt, Ronny Drapkin   +13 more
doaj   +1 more source

Investigating the impact of NHS based ovarian cancer screening [PDF]

, 2010
the UK ovarian cancer is the fifth most common cancer in females and after uterine cancer, the second most common gynaecological cancer. There were 6,596 new cases diagnosed in the UK in 2006.
Nicholson, S. M.
core   +3 more sources

Spatial and temporal epithelial ovarian cancer cell heterogeneity impacts Maraba virus oncolytic potential

BMC Cancer, 2017
Background Epithelial ovarian cancer exhibits extensive interpatient and intratumoral heterogeneity, which can hinder successful treatment strategies.
Jessica G. Tong, Yudith Ramos Valdes, Milani Sivapragasam, John W. Barrett, John C. Bell, David Stojdl, Gabriel E. DiMattia, Trevor G. Shepherd   +7 more
doaj   +1 more source

Animal models of ovarian cancer. [PDF]

, 2003
Ovarian cancer is the most lethal of all of the gynecological cancers and can arise from any cell type of the ovary, including germ cells, granulosa or stromal cells.
Jean-François Ethier, Vanderhyden Barbara C, Shaw, TJ, Ethier Jean-François, Vanderhyden, BC, Shaw, Tanya J, Ethier, JF, Tanya J Shaw, Shaw Tanya J, Vanderhyden, Barbara C, Ethier, Jean-François, Barbara C Vanderhyden   +11 more
core   +1 more source

Insights into high-grade serous carcinoma pathobiology using three-dimensional culture model systems

Journal of Ovarian Research, 2023
Epithelial ovarian cancer (EOC) research has become more complex as researchers try to fully understand the metastatic process. Especially as we delve into the concept of tumour dormancy, where cells transition between proliferative and dormant states to
Emily Tomas, Trevor G. Shepherd
doaj   +1 more source