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TEM1-targeting PEGylated PLGA shikonin nanoformulation for immunomodulation and eradication of ovarian cancer [PDF]
BioImpacts, 2022 Introduction: Tumor endothelial marker 1 (TEM1) is expressed by tumor vascular endothelial cells in various cancers. Methods: Here, we developed poly(lactic-co-glycolic acid) (PLGA) nanoparticles (NPs) PEGylated with polyethylene glycol (PEG) and ...
Efthymia-Iliana Matthaiou +7 more
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Scientific Reports, 2022 High-grade serous ovarian cancer (HGSOC) is an aggressive malignancy often diagnosed at an advanced stage. Although most HGSOC patients respond initially to debulking surgery combined with cytotoxic chemotherapy, many ultimately relapse with platinum ...
Adrian Buensuceso +6 more
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Cell Death and Disease, 2022 PARP inhibitors (PARPi) have revolutionized the therapeutic landscape of epithelial ovarian cancer (EOC) treatment with outstanding benefits in regard to progression-free survival, especially in patients either carrying BRCA1/2 mutations or harboring ...
Ricardo Coelho +8 more
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Scientific Reports, 2023 Ovarian high-grade serous carcinoma (HGSC) is a highly lethal malignancy for which early detection is a challenge and treatment of late-stage disease is ineffective. HGSC initiation involves exfoliation of fallopian tube epithelial (FTE) cells which form
Jacob Haagsma +5 more
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Activated CAMKKβ-AMPK signaling promotes autophagy in a spheroid model of ovarian tumour metastasis
Journal of Ovarian Research, 2020 Background A hallmark of epithelial ovarian cancer (EOC) metastasis is the process of spheroid formation, whereby tumour cells aggregate into 3D structures while in suspension in the peritoneal cavity.
Jeremi Laski +5 more
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L1CAM is required for early dissemination of fallopian tube carcinoma precursors to the ovary
Communications Biology, 2022 L1CAM is implicated as an important factor that enables early fallopian tube cancer precursors to seed the ovary by promoting cell survival through extracellular matrix signaling, thereby facilitating ovarian cancer growth.
Kai Doberstein +13 more
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BMC Cancer, 2017 Background Epithelial ovarian cancer exhibits extensive interpatient and intratumoral heterogeneity, which can hinder successful treatment strategies.
Jessica G. Tong +7 more
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Insights into high-grade serous carcinoma pathobiology using three-dimensional culture model systems
Journal of Ovarian Research, 2023 Epithelial ovarian cancer (EOC) research has become more complex as researchers try to fully understand the metastatic process. Especially as we delve into the concept of tumour dormancy, where cells transition between proliferative and dormant states to
Emily Tomas, Trevor G. Shepherd
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PLoS Medicine, 2012 BackgroundOnly about half the studies that have collected information on the relevance of women's height and body mass index to their risk of developing ovarian cancer have published their results, and findings are inconsistent.
Collaborative Group on Epidemiological Studies of Ovarian Cancer
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Clinical Evaluation of BRCA1/2 Mutation in Mexican Ovarian Cancer Patients
Translational Oncology, 2020 Ovarian cancer (OC) is an important cause of gynecologic cancer-related deaths. In Mexico, around 4700 new cases of OC are diagnosed per year and it represents the second cause of gynecological cancer mortality with more than 2700 deaths.
Dolores Gallardo-Rincón +11 more
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