Results 21 to 30 of about 3,346,248 (200)

MS: Wip1 suppresses angiogenesis through the STAT3-VEGF signalling pathway in serous ovarian cancer

Journal of Ovarian Research, 2022
Multifaceted functions of the so-called “oncogene” Wip1 have been reported in a previous study, while its actual role remains to be explored in serous ovarian cancer (SOC).
Sheng Yin, Lina Yang, Yiyan Zheng, Rongyu Zang   +3 more
doaj   +1 more source

Generation of endogenously tagged E-cadherin cells using gene editing via non-homologous end joining

STAR Protocols, 2023
Summary: We provide a protocol using non-homologous end joining to integrate an oligonucleotide sequence of a fluorescence protein at the CDH1 locus encoding for the epithelial glycoprotein E-cadherin.
Natalie Rimmer, Ching-Yeu Liang, Ricardo Coelho, Monica Nunez Lopez, Francis Jacob   +4 more
doaj   +1 more source

The tumor suppressor protein OPCML potentiates anti-EGFR and anti-HER2 targeted therapy in HER2-positive ovarian and breast cancer. [PDF]

, 2017
OPCML is a tumor suppressor gene that is frequently inactivated in ovarian cancer and many other cancers by somatic methylation. We have previously shown that OPCML exerts its suppressor function by negatively regulating a spectrum of receptor tyrosine ...
Vaughan, S, Jane Antony, Karali, E, Imoh S. Okon, Justin Stebbing, Gabra, H, Arthur B. McKie, Antony, J, McKie, AB, Sebastian Vaughan, Zanini, E, Louay S. Louis, Evdoxia Karali, Mona El-Bahrawy, Louis, LS, Stebbing, J, El-Bahrawy, M, Okon, IS, Chiara Recchi, Hani Gabra, Recchi, C, Elisa Zanini   +21 more
core   +1 more source

Differential expression of mTOR signalling components in drug resistance in ovarian cancer [PDF]

, 2010
This article has been made available through the Brunel Open Access Publishing Fund and is available from the specified link - Copyright @ 2010 The International Institute of Anticancer Research.Background/Aim: A limitation to successful cancer ...
Karteris, E, Foster, H, Goumenou, A, Pados, G, Harvey, AJ, Coley, HM   +5 more
core   +5 more sources

Inactivating mutations and X-ray crystal structure of the tumor suppressor OPCML reveal cancer-associated functions

Nature Communications, 2019
OPCML is a tumour suppressor gene that is epigenetically silenced in ovarian cancer and is somatically mutated in various cancers. Here, the authors solve the X-ray crystal structure of OPCML and model clinically relevant mutations that could contribute ...
James R. Birtley, Mohammad Alomary, Elisa Zanini, Jane Antony, Zachary Maben, Grant C. Weaver, Claudia Von Arx, Manuela Mura, Aline T. Marinho, Haonan Lu, Eloise V. N. Morecroft, Evdoxia Karali, Naomi E. Chayen, Edward W. Tate, Mollie Jurewicz, Lawrence J. Stern, Chiara Recchi, Hani Gabra   +17 more
doaj   +1 more source

Paclitaxel induces immunogenic cell death in ovarian cancer via TLR4/IKK2/SNARE-dependent exocytosis [PDF]

, 2020
Emerging evidence shows that the efficacy of chemotherapeutic drugs are reliant on their capability to induce immunogenic cell death (ICD), thus transforming dying tumor cells into antitumor vaccines. We wanted to uncover potential therapeutic strategies
Yim, So-Fan, Wong, Chi Hang, Yim, So Fan, Chan, Loucia Kit Ying, Man, Gene Chi Wai, Lee, Jacqueline Ho Sze, Cheung, Tak Hong, Lau, Tat San, Chan, Loucia Kit-Ying, Kwong, Joseph, Wong, Chi-Hang, McNeish, Iain A., Man, Gene Chi-Wai, Cheung, Tak-Hong, McNeish, Iain, Lee, Jacqueline Ho-Sze   +15 more
core   +1 more source

Paraneoplastic thrombocytosis in ovarian cancer [PDF]

, 2012
<p>Background: The mechanisms of paraneoplastic thrombocytosis in ovarian cancer and the role that platelets play in abetting cancer growth are unclear.</p> <p>Methods: We analyzed clinical data on 619 patients with epithelial ...
Han, H.D., Wang, R., Collins, K., Drew, A.F., Vasquez, H.G., Coward, J., Deavers, M.T., Urbauer, D., Lamkin, D., Matsuo, K., Sood, A.K., Stone, R.L., Lopez-Berestein, G., Bottsford-Miller, J., Shahzad, M.M.K., King, E.R., Mcneish, I.A., Afshar-Kharghan, V., Gershenson, H., Rupairmoole, R., Ahn, E.H., DeGeest, K., Gushiken, F., Tekedereli, I., Ozpolat, B., Nick, A.M., Chiu, W., Armaiz-Pena, G.N., Lutgendorf, S.K., Landen, C.N., Bond, V.K., Balkwill, F., Hu, W., Pecot, C.V.   +33 more
core   +1 more source

Genes predisposed to DNA hypermethylation during acquired resistance to chemotherapy are identified in ovarian tumors by bivalent chromatin domains at initial diagnosis [PDF]

, 2018
Bivalent chromatin domains containing both active H3K4me3 and repressive H3K27me3 histone marks define gene sets poised for expression or silencing in differentiating embryonic stem (ES) cells.
Edward Curry, Zeller, C, Bowtell, DD, Bowtell, David, Curry, Edward, Wilhelm-Benartzi, Charlotte S., Wilhelm-Benartzi, CS, Patten, DK, Wilhelm-Benartzi, Charlotte, Nahal Masrour, John Gallon, Gallon, J, Zeller, Constanze, Sadaf Ghaem-Maghami, Ghaem-Maghami, S, David D. Bowtell, Masrour, N, Robert Brown, Constanze Zeller, Curry, E, Brown, Robert, Gallon, John, Ghaem-Maghami, Sadaf, Patten, Darren, Brown, R, Patten, Darren K., Bowtell, David D., Masrour, Nahal, Charlotte S. Wilhelm-Benartzi, Darren K. Patten   +29 more
core   +1 more source

Psychological distress and its correlates in ovarian cancer: a systematic review [PDF]

, 2008
Objective: Ovarian cancer is often diagnosed at an advanced stage, and consequently high levels of distress are often experienced. It is necessary to understand the factors associated with psychological distress in order to guide interventions to target ...
Gidron, Y., Arden-Close, Emily, Emily Arden‐Close, Moss-Morris, Rona, Rona Moss‐Morris, Yori Gidron, Moss-Morris, R., Gidron, Yori, Moss-Morris, Rona; id_orcid   +8 more
core   +1 more source

Distinct histopathological features are associated with molecular subtypes and outcome in low grade serous ovarian carcinoma

Scientific Reports, 2023
Low grade serous ovarian carcinoma (LGSOC) demonstrates unique clinical and molecular features compared to other ovarian cancer types. The relationship between common histological features of LGSOC and molecular events, such as hormone receptor ...
Robert L. Hollis, John P. Thomson, Juliette van Baal, Narthana Ilenkovan, Michael Churchman, Koen van de Vijver, Frederike Dijk, Alison M. Meynert, Clare Bartos, Tzyvia Rye, Ian Croy, Patricia Diana, Mignon van Gent, Helen Creedon, Rachel Nirsimloo, Christianne Lok, Charlie Gourley, C. Simon Herrington   +17 more
doaj   +1 more source