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Ovarian Cancer [PDF]

CA: A Cancer Journal for Clinicians, 1986
Early diagnosis is the most effective means of reducing the currently high mortality rate associated with ovarian cancer. The palpation of what appears to be a normal size ovary in a premenopausal woman suggests an ovarian tumor in a postmenopausal woman.
openaire   +6 more sources

Activated CAMKKβ-AMPK signaling promotes autophagy in a spheroid model of ovarian tumour metastasis

Journal of Ovarian Research, 2020
Background A hallmark of epithelial ovarian cancer (EOC) metastasis is the process of spheroid formation, whereby tumour cells aggregate into 3D structures while in suspension in the peritoneal cavity.
Jeremi Laski, Bipradeb Singha, Xu Wang, Yudith Ramos Valdés, Olga Collins, Trevor G. Shepherd   +5 more
doaj   +1 more source

L1CAM is required for early dissemination of fallopian tube carcinoma precursors to the ovary

Communications Biology, 2022
L1CAM is implicated as an important factor that enables early fallopian tube cancer precursors to seed the ovary by promoting cell survival through extracellular matrix signaling, thereby facilitating ovarian cancer growth.
Kai Doberstein, Rebecca Spivak, Hunter D. Reavis, Jagmohan Hooda, Yi Feng, Paul T. Kroeger, Sarah Stuckelberger, Gordon B. Mills, Kyle M. Devins, Lauren E. Schwartz, Marcin P. Iwanicki, Mina Fogel, Peter Altevogt, Ronny Drapkin   +13 more
doaj   +1 more source

Investigating the potential for expediting diagnosis of ovarian cancer via prompt symptom recognition & "targeted screening" [PDF]

, 2009
PhDThis thesis explores the potential for using symptoms as a tool to bring forward the diagnosis of ovarian cancer. Current evidence supports the existence of prediagnostic symptoms, however symptom lead time has yet to be adequately quantified ...
Lim, Anita Wey Wey
core   +4 more sources

Spatial and temporal epithelial ovarian cancer cell heterogeneity impacts Maraba virus oncolytic potential

BMC Cancer, 2017
Background Epithelial ovarian cancer exhibits extensive interpatient and intratumoral heterogeneity, which can hinder successful treatment strategies.
Jessica G. Tong, Yudith Ramos Valdes, Milani Sivapragasam, John W. Barrett, John C. Bell, David Stojdl, Gabriel E. DiMattia, Trevor G. Shepherd   +7 more
doaj   +1 more source

Incomplete pregnancy and risk of ovarian cancer: Results from two Australian case–control studies and systematic review [PDF]

, 2009
Although full-term pregnancies reduce the risk of ovarian cancer, it has not been conclusively established whether incomplete pregnancies also influence risk.
Dick, Marie-Louise B., Purdie, David M., Dick, Marie Louise B, Green, Adele C., The Australian Ovarian Cancer Study Group, Siskind, Vic, Siskind, Victor, Australian Cancer Study Group (Ovarian Group)   +7 more
core   +1 more source

Insights into high-grade serous carcinoma pathobiology using three-dimensional culture model systems

Journal of Ovarian Research, 2023
Epithelial ovarian cancer (EOC) research has become more complex as researchers try to fully understand the metastatic process. Especially as we delve into the concept of tumour dormancy, where cells transition between proliferative and dormant states to
Emily Tomas, Trevor G. Shepherd
doaj   +1 more source

Animal models of ovarian cancer. [PDF]

, 2003
Ovarian cancer is the most lethal of all of the gynecological cancers and can arise from any cell type of the ovary, including germ cells, granulosa or stromal cells.
Jean-François Ethier, Vanderhyden Barbara C, Shaw, TJ, Ethier Jean-François, Vanderhyden, BC, Shaw, Tanya J, Ethier, JF, Tanya J Shaw, Shaw Tanya J, Vanderhyden, Barbara C, Ethier, Jean-François, Barbara C Vanderhyden   +11 more
core   +1 more source

Ovarian cancer and body size: individual participant meta-analysis including 25,157 women with ovarian cancer from 47 epidemiological studies.

PLoS Medicine, 2012
BackgroundOnly about half the studies that have collected information on the relevance of women's height and body mass index to their risk of developing ovarian cancer have published their results, and findings are inconsistent.
Collaborative Group on Epidemiological Studies of Ovarian Cancer
doaj   +1 more source

The ErbB signalling pathway: protein expression and prognostic value in epithelial ovarian cancer [PDF]

, 2008
Ovarian cancer is the most frequent cause of death from gynaecological cancer in the Western world. Current prognostic factors do not allow reliable prediction of response to chemotherapy and survival for individual ovarian cancer patients.
de Bock, G. H., A P G Crijns, Hollema, H., P de Graeff, de Bock, G.H.; id_orcid, de Vries, E.G.; id_orcid, Crijns, A.P.G., G H de Bock, de Bock, G.H., A G J van der Zee, Bartlett, J.M., H G Klip, S de Jong, de Graeff, P., J M Bartlett, van der Zee, A. G. J., Crijns, A. P. G., ten Hoor, K.A., de Vries, E.G.E., van der Zee, A.G.J., Wisman, G.B., ten Hoor, K. A., de Vries, E. G. E., Bartlett, J. M., H Hollema, K A ten Hoor, Klip, H. G., G B A Wisman, de Jong, S., Wisman, G. B. A., Klip, H.G., van der Zee, A.G., de Jong, S.; id_orcid, Crijns, A.P., K Oien, Oien, K., Wisman, G.B.A., de Vries, E.G., E G E de Vries   +38 more
core   +2 more sources