Results 41 to 50 of about 3,449,000 (279)

Molecular mechanisms of ovarian cancer prevention [PDF]

, 2023
Combined oral contraceptive pill (COCP) lowers the risk of ovarian cancer. The risk reduction has been reported as between 33 - 41%. The duration of use affects the risk reduction. The mechanism of risk reduction has been theorised.
Koo, Chail
core   +1 more source

Advancing Research Alongside Patient Partners: Next-Generation Best Practices for Effective Collaboration in Health Research

Current Oncology
Ovarian Cancer Canada’s Patient Partners in Research (PPiR) is a national volunteer-based program that trains and connects individuals with lived ovarian cancer (OC) experience to diverse research opportunities, to maximize the clinical relevance and ...
Ally C. Farrell, Jessica A. Lawson, Ovarian Cancer Canada’s Patient Partners in Research Team, Alison Ross, Alicia A. Tone   +4 more
doaj   +1 more source

Distinct histopathological features are associated with molecular subtypes and outcome in low grade serous ovarian carcinoma

Scientific Reports, 2023
Low grade serous ovarian carcinoma (LGSOC) demonstrates unique clinical and molecular features compared to other ovarian cancer types. The relationship between common histological features of LGSOC and molecular events, such as hormone receptor ...
Robert L. Hollis, John P. Thomson, Juliette van Baal, Narthana Ilenkovan, Michael Churchman, Koen van de Vijver, Frederike Dijk, Alison M. Meynert, Clare Bartos, Tzyvia Rye, Ian Croy, Patricia Diana, Mignon van Gent, Helen Creedon, Rachel Nirsimloo, Christianne Lok, Charlie Gourley, C. Simon Herrington   +17 more
doaj   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Transcriptomic Analyses of Ovarian Clear Cell Carcinoma Spheroids Reveal Distinct Proliferative Phenotypes and Therapeutic Vulnerabilities

Cells
Cancer cell spheroids autonomously form in the ascites fluid and are considered a conduit for epithelial ovarian cancer metastasis within the peritoneal cavity. Spheroids are homotypic, avascular 3D structures that acquire resistance to anoikis to remain
Bart Kolendowski, Sylvia Cheng, Yudith Ramos Valdes, Trevor G. Shepherd, Gabriel E. DiMattia   +4 more
doaj   +1 more source

Control of triple-negative breast cancer using ex vivo self-enriched, costimulated NKG2D CAR T cells

Journal of Hematology & Oncology, 2018
Background Triple-negative breast cancer (TNBC) is an aggressive disease that currently lacks effective targeted therapy. NKG2D ligands (NKG2DLs) are expressed on various tumor types and immunosuppressive cells within tumor microenvironments, providing ...
Yali Han, Wei Xie, De-Gang Song, Daniel J. Powell   +3 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Targeted anti-vascular therapies for ovarian cancer: current evidence [PDF]

, 2013
Ovarian cancer presents at advanced stage in around 75% of women, and despite improvements in treatments such as chemotherapy, the 5-year survival from the disease in women diagnosed between 1996 and 1999 in England and Wales was only 36%.
Mcneish, I., Gore, M., M Hall, Gore, M, C Gourley, Hall, M, Kaye, S, Gourley, C., Ledermann, J, McNeish, I, Jayson, G.; id_orcid, Gourley, C, G Jayson, Jayson, G., Kaye, S., Rustin, G, M Gore, J Ledermann, S Kaye, Perren, T, I McNeish, Hall, M., G Rustin, Rustin, G., Perren, T., T Perren, Jayson, G, Ledermann, J.   +27 more
core   +1 more source

CAMKKβ supports growth and viability of epithelial ovarian cancer in vitro and in vivo

Scientific Reports
Epithelial ovarian cancer (EOC) metastasizes predominantly through multicellular aggregates known as spheroids, which disseminate within the peritoneal cavity and initiate secondary disease upon reattachment at distant sites.
Matthew J. Borrelli, Adrian Buensuceso, Yudith Ramos Valdes, Tiffany P.A. Johnston, Jacob Haagsma, Trevor G. Shepherd   +5 more
doaj   +1 more source

HDAC Inhibition Induces Transient Phenotypic Inertia in Dormant OCCC Spheroids by Derepression of Cell Cycle Genes

Cells
Multicellular cancer cell aggregates, termed spheroids, are anoikis-resistant, avascular, heterogeneous structures responsible for transcoelomic metastasis of ovarian clear cell carcinoma (OCCC).
Sylvia Cheng, Bart Kolendowski, Yudith Ramos-Valdes, Trevor G. Shepherd, Gabriel E. DiMattia   +4 more
doaj   +1 more source