Results 61 to 70 of about 769,731 (345)

Prerequisites to improve surgical cytoreduction in FIGO stage III/IV epithelial ovarian cancer and subsequent clinical ramifications

Journal of Ovarian Research, 2023
Background No residual disease (CC 0) following cytoreductive surgery is pivotal for the prognosis of women with advanced stage epithelial ovarian cancer (EOC).
Diederick de Jong, Amudha Thangavelu, Timothy Broadhead, Inga Chen, Dermot Burke, Richard Hutson, Racheal Johnson, Angelika Kaufmann, Peter Lodge, David Nugent, Aaron Quyn, Georgios Theophilou, Alexandros Laios   +12 more
doaj   +1 more source

Factors Influencing Uptake of Risk-Reducing Salpingo-Oophorectomy by BRCA1 and BRCA2 Mutation Carriers [PDF]

, 2016
Germline mutations in the BRCA1 and BRCA2 genes are associated with significantly increased risks for ovarian cancer. The National Comprehensive Cancer Network (NCCN) currently recommends that female BRCA mutation carriers undergo risk-reducing salpingo ...
Breen, Victoria E
core   +1 more source

Tumor mutational burden as a determinant of metastatic dissemination patterns

Molecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal, Andrea Moreno‐Manuel, Miguel Salvadó‐Pertierra, Cristina Santos‐Vivas, Rebeca Sanz‐Pamplona   +4 more
wiley   +1 more source

Case Report: Thoracoscopic secondary cytoreductive surgery for high-grade serous ovarian cancer

Frontiers in Surgery
The objective of this video is to show the feasibility of secondary cytoreductive surgery for recurrent high-grade serous ovarian cancer. The procedure targets recurrences in the cardiophrenic lymph nodes and the right diaphragm involving the right basal
Luigi Carlo Turco, Benedetta Alberghetti, Carlotta Francesca Cartia, Antonella Biscione, Giacomo Guidi, Giacomo Guidi, Filippo Maria Capomacchia, Andrea Droghetti   +7 more
doaj   +1 more source

LINE-1 ORF1p as a candidate biomarker in high grade serous ovarian carcinoma

Scientific Reports, 2023
Long interspersed element 1 (LINE-1) open reading frame 1 protein (ORF1p) expression is a common feature of many cancer types, including high-grade serous ovarian carcinoma (HGSOC).
Sho Sato, Michael Gillette, Pamela R. de Santiago, Eric Kuhn, Michael Burgess, Kristen Doucette, Yi Feng, Carlos Mendez-Dorantes, Paul J. Ippoliti, Sara Hobday, Marilyn A. Mitchell, Kai Doberstein, Stefan M. Gysler, Michelle S. Hirsch, Lauren Schwartz, Michael J. Birrer, Steven J. Skates, Kathleen H. Burns, Steven A. Carr, Ronny Drapkin   +19 more
doaj   +1 more source

Activation of MAPK signalling results in resistance to saracatinib (AZD0530) in ovarian cancer [PDF]

, 2017
SRC tyrosine kinase is frequently overexpressed and activated in late-stage, poor prognosis ovarian tumours, and preclinical studies have supported the use of targeted SRC inhibitors in the treatment of this disease.
El-Helali, Aya, Kennedy, Richard D., McCabe, Nuala, McGivern, Niamh, Mcneish, Iain A., Mullan, Paul, Paul Harkin, D   +6 more
core   +2 more sources

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Exploiting Cancer Dormancy Signaling Mechanisms in Epithelial Ovarian Cancer Through Spheroid and Organoid Analysis

Cells
Epithelial ovarian cancer (EOC) exhibits a unique mode of metastasis, involving spheroid formation in the peritoneum. Our research on EOC spheroid cell biology has provided valuable insights into the signaling plasticity associated with metastasis.
Emily J. Tomas, Yudith Ramos Valdes, Jennifer Davis, Bart Kolendowski, Adrian Buensuceso, Gabriel E. DiMattia, Trevor G. Shepherd   +6 more
doaj   +1 more source

Genomic and Molecular Landscape of DNA Damage Repair Deficiency across The Cancer Genome Atlas [PDF]

, 2018
DNA damage repair (DDR) pathways modulate cancer risk, progression, and therapeutic response. We systematically analyzed somatic alterations to provide a comprehensive view of DDR deficiency across 33 cancer types.
Alvaro, Domenico, Andrew D, Cherniack, Bin, Feng, Bragazzi, MARIA CONSIGLIA, Cardinale, Vincenzo, Casey S, Greene, Chase, Miller, Chen, Wang, Christina, Yau, David A, Wheeler, Denise, Wolf, Eve, Shinbrot, Galen F, Gao, Gaudio, Eugenio, Gordon B, Mills, Gregory P, Way, Hai, Hu, Haoran, Chen, Hui, Shen, Huihui, Fan, Ilya, Shmulevich, Jianfang, Liu, John N, Weinstein, Lawrence A, Donehower, Lei, Li, Li, Ding, Linghua, Wang, Matthew H, Bailey, Michael T, Zimmermann, Mostafa, Karimi, Nyasha, Chambwe, Peilin, Jia, Peter W, Laird, Pora, Kim, Raymond J, Monnat, Rehan, Akbani, Shaojun, Zhang, Theo A, Knijnenburg, Yang, Shen, Yonghong, Xiao, Yuexin, Liu, Zhongming, Zhao   +41 more
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source