Results 51 to 60 of about 3,449,000 (279)

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Ovarian cancer symptom awareness and anticipated delayed presentation in a population sample [PDF]

, 2014
Background While ovarian cancer is recognised as having identifiable early symptoms, understanding of the key determinants of symptom awareness and early presentation is limited.
White, Ceri, Alice E Simon, Brain, Kate E, Smits, Stephanie, White, C., Brain, Katherine, Hanson, Jane, Brain, K.E., Neal, RD, Grp, ICBPM2W, Lindsay J Forbes, Kate E Brain, on behalf of the ICBP Module 2 Working Group,, Neal, Richard D., Robbe, IJ, Hanson, J, Robbe, Iain, Roberts, C, Smits, S., Smits, S M, Hanson, J., Robbe, I.J., Simon, A.E., Iain J Robbé, John Steward, Roberts, Chris, Brain, KE, Stephanie Smits, Forbes, Lindsay J., Jane Hanson, Roberts, C., Forbes, LJ, Richard D Neal, Simon, Alice E, Ceri White, Forbes, L.J., Chris Roberts, Robbé, Iain J., Steward, John, White, C, Simon, Alice E., Steward, J., Neal, R.D., Simon, AE, Forbes, Lindsay, Forbes, Lindsay J.L., Smits, S, Brain, Kate E., Steward, J, Neal, Richard   +49 more
core   +2 more sources

Diagnosis of ovarian cancer [PDF]

BMJ, 2015
#### The bottom line Ovarian cancer is the seventh most common cancer in women worldwide, with 239 000 new cases diagnosed in 2012.1 As with many other types of cancer, geographical variation in the incidence of and mortality from ovarian cancer is substantial, with a higher incidence in economically developed regions of the world.2 Incidence is ...
Sundar, S, Neal, RD, Kehoe, S
openaire   +3 more sources

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Case Report: Thoracoscopic secondary cytoreductive surgery for high-grade serous ovarian cancer

Frontiers in Surgery
The objective of this video is to show the feasibility of secondary cytoreductive surgery for recurrent high-grade serous ovarian cancer. The procedure targets recurrences in the cardiophrenic lymph nodes and the right diaphragm involving the right basal
Luigi Carlo Turco, Benedetta Alberghetti, Carlotta Francesca Cartia, Antonella Biscione, Giacomo Guidi, Giacomo Guidi, Filippo Maria Capomacchia, Andrea Droghetti   +7 more
doaj   +1 more source

Effective adoptive immunotherapy of triple-negative breast cancer by folate receptor-alpha redirected CAR T cells is influenced by surface antigen expression level

Journal of Hematology & Oncology, 2016
Background The poor prognosis and the limited efficacy of targeted therapy in patients with triple-negative breast cancer (TNBC) have raised the need for alternative therapies.
De-Gang Song, Qunrui Ye, Mathilde Poussin, Jessica A. Chacon, Mariangela Figini, Daniel J. Powell   +5 more
doaj   +1 more source

Prerequisites to improve surgical cytoreduction in FIGO stage III/IV epithelial ovarian cancer and subsequent clinical ramifications

Journal of Ovarian Research, 2023
Background No residual disease (CC 0) following cytoreductive surgery is pivotal for the prognosis of women with advanced stage epithelial ovarian cancer (EOC).
Diederick de Jong, Amudha Thangavelu, Timothy Broadhead, Inga Chen, Dermot Burke, Richard Hutson, Racheal Johnson, Angelika Kaufmann, Peter Lodge, David Nugent, Aaron Quyn, Georgios Theophilou, Alexandros Laios   +12 more
doaj   +1 more source

Inflammation and Ovarian Cancer [PDF]

Cytokine, 2012
Epithelial ovarian cancer (EOC) is a highly lethal gynecological cancer for which overall prognosis has remained poor over the past few decades. A number of theories have been postulated in an effort to explain the etiology of EOC. Noteworthy, these theories likely are not mutually exclusive, as they all converge more or less on the role of ...
Maccio' A, MADEDDU, CLELIA
openaire   +3 more sources

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Exploiting Cancer Dormancy Signaling Mechanisms in Epithelial Ovarian Cancer Through Spheroid and Organoid Analysis

Cells
Epithelial ovarian cancer (EOC) exhibits a unique mode of metastasis, involving spheroid formation in the peritoneum. Our research on EOC spheroid cell biology has provided valuable insights into the signaling plasticity associated with metastasis.
Emily J. Tomas, Yudith Ramos Valdes, Jennifer Davis, Bart Kolendowski, Adrian Buensuceso, Gabriel E. DiMattia, Trevor G. Shepherd   +6 more
doaj   +1 more source