Results 31 to 40 of about 3,449,000 (279)

Genes predisposed to DNA hypermethylation during acquired resistance to chemotherapy are identified in ovarian tumors by bivalent chromatin domains at initial diagnosis [PDF]

, 2018
Bivalent chromatin domains containing both active H3K4me3 and repressive H3K27me3 histone marks define gene sets poised for expression or silencing in differentiating embryonic stem (ES) cells.
Edward Curry, Zeller, C, Bowtell, DD, Bowtell, David, Curry, Edward, Wilhelm-Benartzi, Charlotte S., Wilhelm-Benartzi, CS, Patten, DK, Wilhelm-Benartzi, Charlotte, Nahal Masrour, John Gallon, Gallon, J, Zeller, Constanze, Sadaf Ghaem-Maghami, Ghaem-Maghami, S, David D. Bowtell, Masrour, N, Robert Brown, Constanze Zeller, Curry, E, Brown, Robert, Gallon, John, Ghaem-Maghami, Sadaf, Patten, Darren, Brown, R, Patten, Darren K., Bowtell, David D., Masrour, Nahal, Charlotte S. Wilhelm-Benartzi, Darren K. Patten   +29 more
core   +1 more source

Maternal pelvic size not predictive of daughter's breast cancer or ovarian cancer in a large Swedish cohort. [PDF]

, 2009
Recent studies from Finland reported that maternal pelvic size predicted daughters' breast and ovarian cancer, possibly because maternal pelvic size is a marker for in utero hormone exposure.
Goodman, Anna, Silva, Isabel dos Santos, Silva Idos, S., Mishra, G.D., Koupil, Ilona,, Mishra, Gita D, Koupil, Ilona, Silva, Isabel D., Mishra, Gita D.   +8 more
core   +1 more source

Inactivating mutations and X-ray crystal structure of the tumor suppressor OPCML reveal cancer-associated functions

Nature Communications, 2019
OPCML is a tumour suppressor gene that is epigenetically silenced in ovarian cancer and is somatically mutated in various cancers. Here, the authors solve the X-ray crystal structure of OPCML and model clinically relevant mutations that could contribute ...
James R. Birtley, Mohammad Alomary, Elisa Zanini, Jane Antony, Zachary Maben, Grant C. Weaver, Claudia Von Arx, Manuela Mura, Aline T. Marinho, Haonan Lu, Eloise V. N. Morecroft, Evdoxia Karali, Naomi E. Chayen, Edward W. Tate, Mollie Jurewicz, Lawrence J. Stern, Chiara Recchi, Hani Gabra   +17 more
doaj   +1 more source

Paraneoplastic thrombocytosis in ovarian cancer [PDF]

, 2012
<p>Background: The mechanisms of paraneoplastic thrombocytosis in ovarian cancer and the role that platelets play in abetting cancer growth are unclear.</p> <p>Methods: We analyzed clinical data on 619 patients with epithelial ...
Han, H.D., Wang, R., Collins, K., Drew, A.F., Vasquez, H.G., Coward, J., Deavers, M.T., Urbauer, D., Lamkin, D., Matsuo, K., Sood, A.K., Stone, R.L., Lopez-Berestein, G., Bottsford-Miller, J., Shahzad, M.M.K., King, E.R., Mcneish, I.A., Afshar-Kharghan, V., Gershenson, H., Rupairmoole, R., Ahn, E.H., DeGeest, K., Gushiken, F., Tekedereli, I., Ozpolat, B., Nick, A.M., Chiu, W., Armaiz-Pena, G.N., Lutgendorf, S.K., Landen, C.N., Bond, V.K., Balkwill, F., Hu, W., Pecot, C.V.   +33 more
core   +1 more source

Impact of Radiation Therapy on Physical and Psychosocial Health of Adolescents and Young Adults: A Joint Report From the Children's Oncology Group AYA and Radiation Oncology Committees

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Rates of cancer among adolescents and young adults (AYA), age 15–39 years, are increasing. Consequently, radiation oncologists are treating more AYAs who have diagnoses spanning both pediatric and adult practices. Compared to pediatric and older adult patients, AYAs face a unique set of challenges.
Hesham Elhalawani, Rachel K. Peterson, Avani D. Rao, Laurie J. McKenzie, Ahmed Magdy Elmotayam, Leslie Chang, Michael Roth, Susan L. McGovern   +7 more
wiley   +1 more source

Paclitaxel induces immunogenic cell death in ovarian cancer via TLR4/IKK2/SNARE-dependent exocytosis [PDF]

, 2020
Emerging evidence shows that the efficacy of chemotherapeutic drugs are reliant on their capability to induce immunogenic cell death (ICD), thus transforming dying tumor cells into antitumor vaccines. We wanted to uncover potential therapeutic strategies
Yim, So-Fan, Wong, Chi Hang, Yim, So Fan, Chan, Loucia Kit Ying, Man, Gene Chi Wai, Lee, Jacqueline Ho Sze, Cheung, Tak Hong, Lau, Tat San, Chan, Loucia Kit-Ying, Kwong, Joseph, Wong, Chi-Hang, McNeish, Iain A., Man, Gene Chi-Wai, Cheung, Tak-Hong, McNeish, Iain, Lee, Jacqueline Ho-Sze   +15 more
core   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Whole Tumor Antigen Vaccines: Where Are We?

Vaccines, 2015
With its vast amount of uncharacterized and characterized T cell epitopes available for activating CD4+ T helper and CD8+ cytotoxic lymphocytes simultaneously, whole tumor antigen represents an attractive alternative source of antigens as compared to ...
Cheryl Lai-Lai Chiang, George Coukos, Lana E. Kandalaft   +2 more
doaj   +1 more source

Subtypes of Ovarian Cancer and Ovarian Cancer Screening [PDF]

Diagnostics, 2017
Ovarian cancer is the foremost cause of gynecological cancer death in the developed world, as it is usually diagnosed at an advanced stage. In this paper we discuss current issues, the efficacy and problems associated with ovarian cancer screening, and compare the characteristics of ovarian cancer subtypes. There are two types of ovarian cancer: Type I
Masafumi Koshiyama, Noriomi Matsumura, Ikuo Konishi   +2 more
openaire   +3 more sources

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source