Results 41 to 50 of about 78,550 (267)

OverAKT3: tumor progression and chemoresistance [PDF]

Cell Cycle, 2015
Akt3 is one of 3 closely related serine/threonine-protein kinases in the Akt family (Akt1, Akt2, and Akt3). Akt is among the most hyperactivated oncogenes in human cancer, regulating key cellular functions such as growth, proliferation, migration, invasion, angiogenesis, metabolism, and survival.1,2 Studies evaluating the effect of Akt isoform gene ...
Ping, Ji, Kristen M, Turner, Wei, Zhang
openaire   +2 more sources

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Long noncoding RNA GSTM3TV2 upregulates LAT2 and OLR1 by competitively sponging let-7 to promote gemcitabine resistance in pancreatic cancer

Journal of Hematology & Oncology, 2019
Background Chemoresistance is one of the main causes of poor prognosis in pancreatic cancer patients. Understanding the mechanisms implicated in chemoresistance of pancreatic cancer is critical to improving patient outcomes.
Guangbing Xiong, Chang Liu, Gang Yang, Mengyu Feng, Jianwei Xu, Fangyu Zhao, Lei You, Li Zhou, Lianfang Zheng, Ya Hu, Xiaowo Wang, Taiping Zhang, Yupei Zhao   +12 more
doaj   +1 more source

Role of SIRT1 in Chemoresistant Leukemia

International Journal of Molecular Sciences, 2023
Leukemias of the AML, CML, and CLL types are the most common blood cancers worldwide, making them a major global public health problem. Furthermore, less than 24% of patients treated with conventional chemotherapy (low-risk patients) and 10–15% of patients ineligible for conventional chemotherapy (high-risk patients) survive five years.
Guadalupe Rosario Fajardo-Orduña, Edgar Ledesma-Martínez, Itzen Aguiñiga-Sanchez, Benny Weiss-Steider, Edelmiro Santiago-Osorio   +4 more
openaire   +2 more sources

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Oncologic trogocytosis of an original stromal cells induces chemoresistance of ovarian tumours.

PLoS ONE, 2008
BackgroundThe microenvironment plays a major role in the onset and progression of metastasis. Epithelial ovarian cancer (EOC) tends to metastasize to the peritoneal cavity where interactions within the microenvironment might lead to chemoresistance ...
Arash Rafii, Pejman Mirshahi, Mary Poupot, Anne-Marie Faussat, Anne Simon, Elodie Ducros, Eliane Mery, Bettina Couderc, Raphael Lis, Jerome Capdet, Julie Bergalet, Denis Querleu, Francoise Dagonnet, Jean-Jacques Fournié, Jean-Pierre Marie, Eric Pujade-Lauraine, Gilles Favre, Jeanine Soria, Massoud Mirshahi   +18 more
doaj   +1 more source

Insights into Chemoresistance of Prostate Cancer [PDF]

International Journal of Biological Sciences, 2015
Prostate cancer (PCa) remains the most prevalent malignancy among males in the western world. Though hormonal therapies through chemical or surgical castration have been proposed many years ago, heretofore, such mainstay for the treatment on advanced PCa has not fundamentally changed.
Zhang, Wei, Meng, Yan, Liu, Na, Wen, Xiao-Fei, Yang, Tao   +4 more
openaire   +2 more sources

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

HMGB1 promotes chemoresistance in small cell lung cancer by inducing PARP1-related nucleophagy

Journal of Advanced Research
Introduction: Small cell lung cancer (SCLC) is prone to chemoresistance, which is closely related to genome homeostasis-related processes, such as DNA damage and repair.
Weitao Shen, Qiong Lyu, Ruibin Yi, Yueqin Sun, Wei Zhang, Ting Wei, Yueming Zhang, Jian Shi, Jian Zhang   +8 more
doaj   +1 more source

Hippo/YAP signaling pathway is involved in osteosarcoma chemoresistance

Chinese Journal of Cancer, 2016
Background Osteosarcoma is the most common bone malignancy in children and adolescents, and 20%–30% of the patients suffer from poor prognosis because of individual chemoresistance.
Dong-Yu Wang, Ya-Nan Wu, Jun-Qi Huang, Wei Wang, Meng Xu, Jin-Peng Jia, Gang Han, Bei-Bei Mao, Wen-Zhi Bi   +8 more
doaj   +1 more source