Results 41 to 50 of about 78,175 (168)

Cancer chemoresistance and BAK

Oncoscience, 2015
Blocking or evading apoptosis is one of the hallmarks of cancer [1]. Recent advances in genomic sequencing have identified many mutations in cancer cells, prompting an increased effort to identify driver mutations in critical pathways that impact upon cell survival. Interestingly though, many cancers have intact apoptotic machinery where mutation rates
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Pancreatic Cancer Chemoresistance to Gemcitabine [PDF]

Cancers, 2017
Pancreatic ductal adenocarcinoma (PDAC), commonly referred to as pancreatic cancer, ranks among the leading causes of cancer-related deaths in the Western world due to disease presentation at an advanced stage, early metastasis and generally a very limited response to chemotherapy or radiotherapy.
Manoj Amrutkar, Ivar Gladhaug
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Exosome-transmitted LUCAT1 promotes stemness transformation and chemoresistance in bladder cancer by binding to IGF2BP2

Journal of Experimental & Clinical Cancer Research
The chemotherapy resistance is an awkward challenge in management of bladder cancer (BC). Cancer organoid model is an effective preclinical tumor model that could faithfully represent clinical manifestations and simulate the biological processes of ...
Yonghao Zhan, Zhenzhen Zhou, Zhaowei Zhu, Lianghao Zhang, Shuanbao Yu, Yuchen Liu, Xuepei Zhang   +6 more
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Warburg effect and lactylation in cancer: mechanisms for chemoresistance

Molecular Medicine
In the clinical management of cancers, the emergence of chemoresistance represents a profound and imperative “pain point” that requires immediate attention. Understanding the mechanisms of chemoresistance is essential for developing effective therapeutic
Wenjie Zhang, Min Xia, Jiahui Li, Gaohua Liu, Yan Sun, Xisha Chen, Jing Zhong   +6 more
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MiR-193a regulates chemoresistance of human osteosarcoma cells via repression of IRS2

Journal of Bone Oncology, 2019
Chemoresistance prevents curative potential of chemotherapy in most cases. MicroRNAs (miRNAs) are key players in regulating chemoresistance in osteosarcoma, which is the most common primary bone cancer. Bisulfite sequencing and quantitative real time PCR
Haiyan Wang, Fangfang Zhao, Shanbao Cai, Youguang Pu   +3 more
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Autophagy is associated with chemoresistance in neuroblastoma [PDF]

BMC Cancer, 2016
Neuroblastoma (NB) is a frequent pediatric tumor characterized by a poor prognosis where a majority of tumors progress despite intensive multimodality treatments. Autophagy, a self-degradative process in cells, could be induced by chemotherapy and be associated with chemoresistance.
Belounis, Assila, Nyalendo, Carine, Le Gall, Roxane, Imbriglio, Tina V., Mahma, Mohamed, Teira, Pierre, Beaunoyer, Mona, Cournoyer, Sonia, Haddad, Elie, Vassal, Gilles, Sartelet, Hervé   +10 more
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KLF4 in cancer chemoresistance: molecular mechanisms and therapeutic implications

Discover Oncology
Chemoresistance is a major obstacle in cancer treatment, and it often results in treatment failure and disease progression. Among the plethora of factors contributing to chemoresistance, the transcription factor Krüppel-like factor 4 (KLF4) has emerged ...
Suresh Singh Yadav, Punita Kalia, Navneet Kaur, Sourav Sharma, Shambhavi Thakur, Soni Kumari, Rohini Ravindran Nair   +6 more
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DNA-methylation eraser TET2 activates WTIP expression to suppress an AKT-dependent chemoresistance of gastric cancer

Neoplasia: An International Journal for Oncology Research
Chemoresistance is one of the major causes of the failure in gastric cancer (GC) treatment and leads to poor clinical outcomes. Ten-eleven translocation (TET) 2 expression and activity are frequently reduced in solid tumors.
Yan Guo, Hongyang Yu, Jinyang Li, Kewei Liu, Mengyi Han, Yuxin Tang, Li Su, Xianfeng Li, Haixia Wu, Dongfeng Chen   +9 more
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Long noncoding RNA MALAT1 regulates autophagy associated chemoresistance via miR-23b-3p sequestration in gastric cancer

Molecular Cancer, 2017
Background Chemoresistance has long been recognized as a major obstacle in cancer therapy. Clarifying the underlying mechanism of chemoresistance would result in novel strategies to improve patient’s response to chemotherapeutics.
Hu YiRen, Yu YingCong, You Sunwu, Li Keqin, Tong Xiaochun, Chen Senrui, Chen Ende, Lin XiZhou, Chen Yanfan   +8 more
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Desmoplasia and Chemoresistance in Pancreatic Cancer [PDF]

Cancers, 2014
Pancreatic ductal adenocarcinoma (PDAC) occurs mainly in people older than 50 years of age. Although great strides have been taken in treating PDAC over the past decades its incidence nearly equals its mortality rate and it was quoted as the 4th leading cause of cancer deaths in the U.S. in 2012.
Schober, Marvin, Jesenofsky, Ralf, Faissner, Ralf, Weidenauer, Cornelius, Hagmann, Wolfgang, Michl, Patrick, Heuchel, Rainer L., Haas, Stephan L., Löhr, J.-Matthias   +8 more
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