Results 51 to 60 of about 78,175 (168)

HOW DOES TOXOPLASMA GONDII MODULATE NEURONAL RESPONSES AND ANTIGEN PRESENTATION TO EVADE IMMUNE RECOGNITION DURING LATENT INFECTION?

IBRO Neuroscience Reports, 2023
Renzo Gutierrez Loli, Amel Aïda, Marcy Belloy, Mohamed Hakimi, Nicolas Blanchard   +4 more
doaj   +1 more source

NEK6 dampens FOXO3 nuclear translocation to stabilize C-MYC and promotes subsequent de novo purine synthesis to support ovarian cancer chemoresistance

Cell Death and Disease
De novo purine synthesis metabolism plays a crucial role in tumor cell survival and malignant progression. However, the specific impact of this metabolic pathway on chemoresistance in ovarian cancer remains unclear.
Jingchun Liu, Haoyu Wang, Huanzhi Wan, Jiang Yang, Likun Gao, Zhi Wang, Xiaoyi Zhang, Wuyue Han, Jiaxin Peng, Lian Yang, Li Hong   +10 more
doaj   +1 more source

Ubiquitin-Specific Peptidase 22 Contributes to Colorectal Cancer Stemness and Chemoresistance via Wnt/β-Catenin Pathway

Cellular Physiology and Biochemistry, 2018
Background/Aims: Two major barriers to the successful treatment of colorectal cancer (CRC) are the development of stem cell-like characteristics (stemness) and chemoresistance.
Shixiong Jiang, Chenxin Song, Xinyu Gu, Muhong Wang, Dazhuang Miao, Jiachen Lv, Yanlong Liu   +6 more
doaj   +1 more source

High expression of olfactomedin-4 is correlated with chemoresistance and poor prognosis in pancreatic cancer.

PLoS ONE, 2020
Pancreatic cancer has an extremely poor prognosis, and identification of novel predictors of therapeutic efficacy and prognosis is urgently needed. Chemoresistance-related molecules are correlated with poor prognosis and may be effective targets for ...
Ryotaro Ohkuma, Erica Yada, Shumpei Ishikawa, Daisuke Komura, Hidenobu Ishizaki, Koji Tamada, Yutaro Kubota, Kazuyuki Hamada, Hiroo Ishida, Yuya Hirasawa, Hirotsugu Ariizumi, Etsuko Satoh, Midori Shida, Makoto Watanabe, Rie Onoue, Kiyohiro Ando, Junji Tsurutani, Kiyoshi Yoshimura, Takehiko Yokobori, Tetsuro Sasada, Takeshi Aoki, Masahiko Murakami, Tomoko Norose, Nobuyuki Ohike, Masafumi Takimoto, Masahiko Izumizaki, Shinichi Kobayashi, Takuya Tsunoda, Satoshi Wada   +28 more
doaj   +1 more source

Advances in the Relationship between MicroRNA and Cisplatin Resistance 
of Lung Cancer

Chinese Journal of Lung Cancer, 2014
MicroRNAs (miRNAs) are a class of small, about 22 nucleotides endogenous noncoding RNAs that negatively regulate their target genes’ expression through post-transcriptional suppression.
Fang ZHANG, Yang LI, Qinghua ZHOU
doaj   +1 more source

Fatty acid receptor GPR120 promotes breast cancer chemoresistance by upregulating ABC transporters expression and fatty acid synthesisResearch in context

EBioMedicine, 2019
Background: Chemoresistance is the major cause of neoadjuvant treatment failure in breast cancer patients. Despite recent progress, the mechanism underlying chemoresistance remains to be further defined.
Xue Wang, Songbing He, Yuting Gu, Qiwei Wang, Xiao Chu, Min Jin, Liang Xu, Qiong Wu, Qianjun Zhou, Bei Wang, Yanyun Zhang, Hui Wang, Leizhen Zheng   +12 more
doaj   +1 more source

CRISPR screens reveal convergent targeting strategies against evolutionarily distinct chemoresistance in cancer

Nature Communications
Resistance to chemotherapy has been a major hurdle that limits therapeutic benefits for many types of cancer. Here we systematically identify genetic drivers underlying chemoresistance by performing 30 genome-scale CRISPR knockout screens for seven ...
Chunge Zhong, Wen-Jie Jiang, Yingjia Yao, Zexu Li, You Li, Shengnan Wang, Xiaofeng Wang, Wenjuan Zhu, Siqi Wu, Jing Wang, Shuangshuang Fan, Shixin Ma, Yeshu Liu, Han Zhang, Wenchang Zhao, Lu Zhao, Yi Feng, Zihan Li, Ruifang Guo, Li Yu, Fengyun Pei, Jun Hu, Xingzhi Feng, Zihuan Yang, Zhengjia Yang, Xueying Yang, Yue Hou, Danni Zhang, Dake Xu, Ren Sheng, Yihao Li, Lijun Liu, Hua-Jun Wu, Jun Huang, Teng Fei   +34 more
doaj   +1 more source

The “stem” of chemoresistance [PDF]

Cell Cycle, 2010
Giulia, Bertolini, Laura, Gatti, Luca, Roz   +2 more
openaire   +2 more sources

Identification of An mtDNA Setpoint Associated with Highest Levels of CD44 Positivity and Chemoresistance in HGC-27 and MKN-45 Gastric Cancer Cell Lines

Cell Journal, 2018
Objective Cancer stem cells (CSCs) have important roles in survival and chemoresistance. These cells are commonly recognized with CD44 and CD24 markers.
Gökhan Terzioğlu, Özlem Türksoy, Ömer Faruk Bayrak   +2 more
doaj   +1 more source

Mechanisms Underlying Chemoresistance of Choriocarcinoma Investigated with NMR-Based Metabonomics

Chinese Journal of Magnetic Resonance, 2019
Choriocarcinoma (CC) is a malignant trophoblastic tumor that occurs in women of childbearing age. Its cure rate could be over 90% following single drug or multidrug chemotherapy with methotrexate, 5-fluorouracil and etc. Chemoresistance is the main cause
DING Lai-feng, ZHANG Cong-cong, HU Qing-yu, Olivier E. PARDO, Michael J. SECKL, WANG Yu-lan, WU Jun-fang   +6 more
doaj   +1 more source